Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1207
Gene name	Chloride nucleotide-sensitive channel 1A
Gene symbol	CLNS1A
Synonyms (NCBI Gene)	CLCICLNS1BICln
Chromosome	11
Chromosome location	11q14.1
Summary	This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activa

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031611	hsa-miR-16-5p	Proteomics	18668040
MIRT048993	hsa-miR-92a-3p	CLASH	23622248
MIRT452165	hsa-miR-1245b-5p	PAR-CLIP	23592263
MIRT452164	hsa-miR-3142	PAR-CLIP	23592263
MIRT452163	hsa-miR-1295b-3p	PAR-CLIP	23592263
MIRT452162	hsa-miR-4761-5p	PAR-CLIP	23592263
MIRT452161	hsa-miR-8064	PAR-CLIP	23592263
MIRT452160	hsa-miR-24-1-5p	PAR-CLIP	23592263
MIRT452159	hsa-miR-24-2-5p	PAR-CLIP	23592263
MIRT452158	hsa-miR-8065	PAR-CLIP	23592263
MIRT452165	hsa-miR-1245b-5p	PAR-CLIP	23592263
MIRT452164	hsa-miR-3142	PAR-CLIP	23592263
MIRT452163	hsa-miR-1295b-3p	PAR-CLIP	23592263
MIRT452162	hsa-miR-4761-5p	PAR-CLIP	23592263
MIRT452161	hsa-miR-8064	PAR-CLIP	23592263
MIRT452160	hsa-miR-24-1-5p	PAR-CLIP	23592263
MIRT452159	hsa-miR-24-2-5p	PAR-CLIP	23592263
MIRT452158	hsa-miR-8065	PAR-CLIP	23592263
MIRT897505	hsa-miR-1224-5p	CLIP-seq
MIRT897506	hsa-miR-1283	CLIP-seq
MIRT897507	hsa-miR-1304	CLIP-seq
MIRT897508	hsa-miR-1322	CLIP-seq
MIRT897509	hsa-miR-138	CLIP-seq
MIRT897510	hsa-miR-1914	CLIP-seq
MIRT897511	hsa-miR-197	CLIP-seq
MIRT897512	hsa-miR-2053	CLIP-seq
MIRT897513	hsa-miR-21	CLIP-seq
MIRT897514	hsa-miR-2117	CLIP-seq
MIRT897515	hsa-miR-2909	CLIP-seq
MIRT897516	hsa-miR-3120-5p	CLIP-seq
MIRT897517	hsa-miR-3121-3p	CLIP-seq
MIRT897518	hsa-miR-3133	CLIP-seq
MIRT897519	hsa-miR-3182	CLIP-seq
MIRT897520	hsa-miR-3190	CLIP-seq
MIRT897521	hsa-miR-3616-5p	CLIP-seq
MIRT897522	hsa-miR-3647-5p	CLIP-seq
MIRT897523	hsa-miR-376c	CLIP-seq
MIRT897524	hsa-miR-3915	CLIP-seq
MIRT897525	hsa-miR-4264	CLIP-seq
MIRT897526	hsa-miR-4275	CLIP-seq
MIRT897527	hsa-miR-4299	CLIP-seq
MIRT897528	hsa-miR-4464	CLIP-seq
MIRT897529	hsa-miR-4504	CLIP-seq
MIRT897530	hsa-miR-4511	CLIP-seq
MIRT897531	hsa-miR-4686	CLIP-seq
MIRT897532	hsa-miR-4689	CLIP-seq
MIRT897533	hsa-miR-4748	CLIP-seq
MIRT897534	hsa-miR-4751	CLIP-seq
MIRT897535	hsa-miR-4768-5p	CLIP-seq
MIRT897536	hsa-miR-4797-3p	CLIP-seq
MIRT897537	hsa-miR-483-3p	CLIP-seq
MIRT897538	hsa-miR-508-5p	CLIP-seq
MIRT897539	hsa-miR-5096	CLIP-seq
MIRT897540	hsa-miR-513c	CLIP-seq
MIRT897541	hsa-miR-514b-5p	CLIP-seq
MIRT897542	hsa-miR-520a-5p	CLIP-seq
MIRT897543	hsa-miR-520d-5p	CLIP-seq
MIRT897544	hsa-miR-524-5p	CLIP-seq
MIRT897545	hsa-miR-525-5p	CLIP-seq
MIRT897546	hsa-miR-549	CLIP-seq
MIRT897547	hsa-miR-561	CLIP-seq
MIRT897548	hsa-miR-573	CLIP-seq
MIRT897549	hsa-miR-582-3p	CLIP-seq
MIRT897550	hsa-miR-590-5p	CLIP-seq
MIRT897551	hsa-miR-621	CLIP-seq
MIRT897552	hsa-miR-7	CLIP-seq
MIRT897553	hsa-miR-759	CLIP-seq
MIRT1966124	hsa-miR-1279	CLIP-seq
MIRT897508	hsa-miR-1322	CLIP-seq
MIRT1966125	hsa-miR-1912	CLIP-seq
MIRT897510	hsa-miR-1914	CLIP-seq
MIRT897511	hsa-miR-197	CLIP-seq
MIRT897513	hsa-miR-21	CLIP-seq
MIRT1966126	hsa-miR-3130-5p	CLIP-seq
MIRT897520	hsa-miR-3190	CLIP-seq
MIRT897523	hsa-miR-376c	CLIP-seq
MIRT1966127	hsa-miR-4257	CLIP-seq
MIRT1966128	hsa-miR-4482	CLIP-seq
MIRT897531	hsa-miR-4686	CLIP-seq
MIRT897537	hsa-miR-483-3p	CLIP-seq
MIRT897538	hsa-miR-508-5p	CLIP-seq
MIRT897539	hsa-miR-5096	CLIP-seq
MIRT1966129	hsa-miR-510	CLIP-seq
MIRT1966130	hsa-miR-512-5p	CLIP-seq
MIRT897542	hsa-miR-520a-5p	CLIP-seq
MIRT897543	hsa-miR-520d-5p	CLIP-seq
MIRT897544	hsa-miR-524-5p	CLIP-seq
MIRT897545	hsa-miR-525-5p	CLIP-seq
MIRT897547	hsa-miR-561	CLIP-seq
MIRT897550	hsa-miR-590-5p	CLIP-seq
MIRT897551	hsa-miR-621	CLIP-seq
MIRT1966131	hsa-miR-656	CLIP-seq
MIRT897552	hsa-miR-7	CLIP-seq
MIRT897553	hsa-miR-759	CLIP-seq
MIRT897505	hsa-miR-1224-5p	CLIP-seq
MIRT897507	hsa-miR-1304	CLIP-seq
MIRT897508	hsa-miR-1322	CLIP-seq
MIRT1966125	hsa-miR-1912	CLIP-seq
MIRT897511	hsa-miR-197	CLIP-seq
MIRT897513	hsa-miR-21	CLIP-seq
MIRT2201933	hsa-miR-28-5p	CLIP-seq
MIRT897515	hsa-miR-2909	CLIP-seq
MIRT897517	hsa-miR-3121-3p	CLIP-seq
MIRT1966126	hsa-miR-3130-5p	CLIP-seq
MIRT2201934	hsa-miR-3139	CLIP-seq
MIRT897520	hsa-miR-3190	CLIP-seq
MIRT897523	hsa-miR-376c	CLIP-seq
MIRT897524	hsa-miR-3915	CLIP-seq
MIRT1966127	hsa-miR-4257	CLIP-seq
MIRT1966128	hsa-miR-4482	CLIP-seq
MIRT897531	hsa-miR-4686	CLIP-seq
MIRT897532	hsa-miR-4689	CLIP-seq
MIRT897534	hsa-miR-4751	CLIP-seq
MIRT897537	hsa-miR-483-3p	CLIP-seq
MIRT897538	hsa-miR-508-5p	CLIP-seq
MIRT897539	hsa-miR-5096	CLIP-seq
MIRT1966129	hsa-miR-510	CLIP-seq
MIRT1966130	hsa-miR-512-5p	CLIP-seq
MIRT897542	hsa-miR-520a-5p	CLIP-seq
MIRT897543	hsa-miR-520d-5p	CLIP-seq
MIRT897544	hsa-miR-524-5p	CLIP-seq
MIRT897545	hsa-miR-525-5p	CLIP-seq
MIRT897546	hsa-miR-549	CLIP-seq
MIRT897547	hsa-miR-561	CLIP-seq
MIRT897550	hsa-miR-590-5p	CLIP-seq
MIRT897551	hsa-miR-621	CLIP-seq
MIRT1966131	hsa-miR-656	CLIP-seq
MIRT897552	hsa-miR-7	CLIP-seq
MIRT2201935	hsa-miR-708	CLIP-seq
MIRT897553	hsa-miR-759	CLIP-seq
MIRT1966125	hsa-miR-1912	CLIP-seq
MIRT1966126	hsa-miR-3130-5p	CLIP-seq
MIRT1966127	hsa-miR-4257	CLIP-seq
MIRT1966128	hsa-miR-4482	CLIP-seq
MIRT1966129	hsa-miR-510	CLIP-seq
MIRT1966130	hsa-miR-512-5p	CLIP-seq
MIRT2504993	hsa-miR-154	CLIP-seq
MIRT897511	hsa-miR-197	CLIP-seq
MIRT897513	hsa-miR-21	CLIP-seq
MIRT2201933	hsa-miR-28-5p	CLIP-seq
MIRT897516	hsa-miR-3120-5p	CLIP-seq
MIRT2504994	hsa-miR-3124-3p	CLIP-seq
MIRT897518	hsa-miR-3133	CLIP-seq
MIRT2201934	hsa-miR-3139	CLIP-seq
MIRT2504995	hsa-miR-3148	CLIP-seq
MIRT897520	hsa-miR-3190	CLIP-seq
MIRT2504996	hsa-miR-3652	CLIP-seq
MIRT2504997	hsa-miR-3679-3p	CLIP-seq
MIRT897523	hsa-miR-376c	CLIP-seq
MIRT2504998	hsa-miR-3940-5p	CLIP-seq
MIRT2504999	hsa-miR-3978	CLIP-seq
MIRT897525	hsa-miR-4264	CLIP-seq
MIRT2505000	hsa-miR-4430	CLIP-seq
MIRT2505001	hsa-miR-4463	CLIP-seq
MIRT2505002	hsa-miR-4490	CLIP-seq
MIRT2505003	hsa-miR-4494	CLIP-seq
MIRT2505004	hsa-miR-4507	CLIP-seq
MIRT897530	hsa-miR-4511	CLIP-seq
MIRT897531	hsa-miR-4686	CLIP-seq
MIRT2505005	hsa-miR-4714-3p	CLIP-seq
MIRT2505006	hsa-miR-4753-3p	CLIP-seq
MIRT2505007	hsa-miR-4771	CLIP-seq
MIRT897536	hsa-miR-4797-3p	CLIP-seq
MIRT897537	hsa-miR-483-3p	CLIP-seq
MIRT897538	hsa-miR-508-5p	CLIP-seq
MIRT897539	hsa-miR-5096	CLIP-seq
MIRT897540	hsa-miR-513c	CLIP-seq
MIRT897541	hsa-miR-514b-5p	CLIP-seq
MIRT897542	hsa-miR-520a-5p	CLIP-seq
MIRT897545	hsa-miR-525-5p	CLIP-seq
MIRT2505008	hsa-miR-548u	CLIP-seq
MIRT897546	hsa-miR-549	CLIP-seq
MIRT897549	hsa-miR-582-3p	CLIP-seq
MIRT897550	hsa-miR-590-5p	CLIP-seq
MIRT897551	hsa-miR-621	CLIP-seq
MIRT2505009	hsa-miR-629	CLIP-seq
MIRT897552	hsa-miR-7	CLIP-seq
MIRT2201935	hsa-miR-708	CLIP-seq
MIRT897553	hsa-miR-759	CLIP-seq
MIRT2505010	hsa-miR-875-3p	CLIP-seq
MIRT2505011	hsa-miR-922	CLIP-seq
MIRT897506	hsa-miR-1283	CLIP-seq
MIRT2504993	hsa-miR-154	CLIP-seq
MIRT897510	hsa-miR-1914	CLIP-seq
MIRT897511	hsa-miR-197	CLIP-seq
MIRT897513	hsa-miR-21	CLIP-seq
MIRT2201933	hsa-miR-28-5p	CLIP-seq
MIRT897515	hsa-miR-2909	CLIP-seq
MIRT897516	hsa-miR-3120-5p	CLIP-seq
MIRT897517	hsa-miR-3121-3p	CLIP-seq
MIRT2504994	hsa-miR-3124-3p	CLIP-seq
MIRT897518	hsa-miR-3133	CLIP-seq
MIRT2201934	hsa-miR-3139	CLIP-seq
MIRT2504995	hsa-miR-3148	CLIP-seq
MIRT2504997	hsa-miR-3679-3p	CLIP-seq
MIRT897523	hsa-miR-376c	CLIP-seq
MIRT2504998	hsa-miR-3940-5p	CLIP-seq
MIRT2504999	hsa-miR-3978	CLIP-seq
MIRT897525	hsa-miR-4264	CLIP-seq
MIRT2505001	hsa-miR-4463	CLIP-seq
MIRT2505002	hsa-miR-4490	CLIP-seq
MIRT2505003	hsa-miR-4494	CLIP-seq
MIRT2505004	hsa-miR-4507	CLIP-seq
MIRT897530	hsa-miR-4511	CLIP-seq
MIRT897531	hsa-miR-4686	CLIP-seq
MIRT2505005	hsa-miR-4714-3p	CLIP-seq
MIRT2505006	hsa-miR-4753-3p	CLIP-seq
MIRT2678320	hsa-miR-4760-3p	CLIP-seq
MIRT2505007	hsa-miR-4771	CLIP-seq
MIRT897536	hsa-miR-4797-3p	CLIP-seq
MIRT897537	hsa-miR-483-3p	CLIP-seq
MIRT897538	hsa-miR-508-5p	CLIP-seq
MIRT897539	hsa-miR-5096	CLIP-seq
MIRT897540	hsa-miR-513c	CLIP-seq
MIRT897541	hsa-miR-514b-5p	CLIP-seq
MIRT897543	hsa-miR-520d-5p	CLIP-seq
MIRT897544	hsa-miR-524-5p	CLIP-seq
MIRT2505008	hsa-miR-548u	CLIP-seq
MIRT897546	hsa-miR-549	CLIP-seq
MIRT897547	hsa-miR-561	CLIP-seq
MIRT897549	hsa-miR-582-3p	CLIP-seq
MIRT897550	hsa-miR-590-5p	CLIP-seq
MIRT897551	hsa-miR-621	CLIP-seq
MIRT2505009	hsa-miR-629	CLIP-seq
MIRT2201935	hsa-miR-708	CLIP-seq
MIRT2505011	hsa-miR-922	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000387	Process	Spliceosomal snRNP assembly	IBA
GO:0000387	Process	Spliceosomal snRNP assembly	IDA	18984161
GO:0000387	Process	Spliceosomal snRNP assembly	IEA
GO:0000387	Process	Spliceosomal snRNP assembly	NAS	11756452
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	11756452, 16087681, 18984161, 21081503, 21988832, 22365833, 25416956, 28514442, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	21081503
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005681	Component	Spliceosomal complex	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	18984161, 21081503
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9359436
GO:0005929	Component	Cilium	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0006884	Process	Cell volume homeostasis	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0034709	Component	Methylosome	IDA	11756452, 18984161
GO:0034709	Component	Methylosome	IEA
GO:0034715	Component	PICln-Sm protein complex	IBA
GO:0034715	Component	PICln-Sm protein complex	IDA	18984161
GO:0034715	Component	PICln-Sm protein complex	IEA
GO:0045292	Process	MRNA cis splicing, via spliceosome	IBA
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	NAS	11756452

MIM	HGNC	e!Ensembl
602158	2080	ENSG00000074201

P54105

Protein name

Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)

Protein function

Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear r

PDB

6V0O , 9E3A , 9E3B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03517	Voldacs	35 → 164	Regulator of volume decrease after cellular swelling	Domain

Sequence

MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPT
ISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKS
ALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAE
GQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH

Sequence length

237

Interactions

View interactions

	Reactome
			snRNP Assembly

CLNS1A (chloride nucleotide-sensitive channel 1A)