Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein
Entrez ID	118426
Gene name	BLOC-1 related complex subunit 5
Gene symbol	BORCS5
Synonyms (NCBI Gene)	LOH12CR1LOH1CR12
Chromosome	12
Chromosome location	12p13.2

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1555155556	G>T	Likely-pathogenic	Splice acceptor variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT664015	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT664014	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT664013	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT664012	hsa-miR-4421	HITS-CLIP	23824327
MIRT664011	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT664010	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT664009	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT664008	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT664007	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT664006	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT664005	hsa-miR-4725-5p	HITS-CLIP	23824327
MIRT614361	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT614360	hsa-miR-764	HITS-CLIP	23824327
MIRT614359	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT614358	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT637611	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT637610	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT614357	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT614356	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT614355	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT614354	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT614353	hsa-miR-6128	HITS-CLIP	23824327
MIRT614352	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT614351	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT614350	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT614349	hsa-miR-1299	HITS-CLIP	23824327
MIRT614348	hsa-miR-640	HITS-CLIP	23824327
MIRT614361	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT614360	hsa-miR-764	HITS-CLIP	23824327
MIRT614359	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT614358	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT637611	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT637610	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT614357	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT614356	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT614355	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT614354	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT614353	hsa-miR-6128	HITS-CLIP	23824327
MIRT614352	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT614351	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT614350	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT614349	hsa-miR-1299	HITS-CLIP	23824327
MIRT614348	hsa-miR-640	HITS-CLIP	23824327
MIRT614361	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT614360	hsa-miR-764	HITS-CLIP	23824327
MIRT614359	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT614358	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT614357	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT614356	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT614355	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT614354	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT614353	hsa-miR-6128	HITS-CLIP	23824327
MIRT614352	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT614351	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT614350	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT614349	hsa-miR-1299	HITS-CLIP	23824327
MIRT614348	hsa-miR-640	HITS-CLIP	23824327
MIRT530251	hsa-miR-362-5p	PAR-CLIP	22012620
MIRT530250	hsa-miR-500b-5p	PAR-CLIP	22012620
MIRT530249	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT530248	hsa-miR-5196-3p	PAR-CLIP	22012620
MIRT530247	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT530246	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT530245	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT530244	hsa-miR-6870-3p	PAR-CLIP	22012620
MIRT530243	hsa-miR-7108-5p	PAR-CLIP	22012620
MIRT530242	hsa-miR-4474-3p	PAR-CLIP	22012620

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 25898167, 32296183, 32814053
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005873	Component	Plus-end kinesin complex	IDA	25898167
GO:0005886	Component	Plasma membrane	IDA
GO:0007399	Process	Nervous system development	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	IMP	25898167
GO:0030424	Component	Axon	IEA
GO:0030672	Component	Synaptic vesicle membrane	IBA
GO:0032418	Process	Lysosome localization	IBA
GO:0032418	Process	Lysosome localization	IEA
GO:0032418	Process	Lysosome localization	IMP	25898167
GO:0032418	Process	Lysosome localization	NAS	25898167
GO:0051036	Process	Regulation of endosome size	NAS	31314175
GO:0062196	Process	Regulation of lysosome size	NAS	31314175
GO:0072384	Process	Organelle transport along microtubule	IBA
GO:0072384	Process	Organelle transport along microtubule	IEA
GO:0072384	Process	Organelle transport along microtubule	IMP	25898167
GO:0072384	Process	Organelle transport along microtubule	NAS	25898167
GO:0098574	Component	Cytoplasmic side of lysosomal membrane	IBA
GO:0098574	Component	Cytoplasmic side of lysosomal membrane	IMP	25898167
GO:0098574	Component	Cytoplasmic side of lysosomal membrane	NAS	25898167
GO:0099078	Component	BORC complex	IBA
GO:0099078	Component	BORC complex	IDA	25898167
GO:0099078	Component	BORC complex	IPI	25898167
GO:1903744	Process	Positive regulation of anterograde synaptic vesicle transport	IBA

MIM	HGNC	e!Ensembl
616598	17950	ENSG00000165714

Q969J3

Protein name

BLOC-1-related complex subunit 5 (Loss of heterozygosity 12 chromosomal region 1) (Myristoylated lysosomal protein) (Myrlysin)

Protein function

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed k

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10158	LOH1CR12	61 → 191	Tumour suppressor protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:11896457, ECO:0000269|PubMed:25898167}.

Sequence

MGSEQSSEAESRPNDLNSSVTPSPAKHRAKMDDIVVVAQGSQASRNVSNDPDVIKLQEIP
TFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKE
MDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEG
ERLEPFSMKPDRELRL

Sequence length

196

Interactions

View interactions

BORCS5 (BLOC-1 related complex subunit 5)