DCD (dermcidin)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
117159
Gene name Gene Name - the full gene name approved by the HGNC.
Dermcidin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DCD
Synonyms (NCBI Gene) Gene synonyms aliases
AIDD, DCD-1, DSEP, HCAP, PIF
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-te
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT032404 hsa-let-7b-5p Proteomics 18668040
MIRT925859 hsa-miR-513a-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005576 Component Extracellular region IBA 21873635
GO:0005576 Component Extracellular region IDA 9736629
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606634 14669 ENSG00000161634
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P81605
Protein name Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]
Protein function [DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed:11694882, PubMed:23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen memb
PDB 2KSG , 2NDK , 2YMK , 6SHK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15291 Dermcidin 19 → 106 Dermcidin, antibiotic peptide Domain
Tissue specificity TISSUE SPECIFICITY: Detected in urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Constitutively expressed in eccrine sweat gland cells (at protein level). Secreted into the sweat at a concentration of 1-10 micrograms/ml. {ECO:
Sequence
Sequence length 110
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Antimicrobial peptides
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Dementia Dementia GWAS
Show/Hide Text Mining Associations (33)
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Inhibit 25673161
Alzheimer Disease Associate 27327445
Breast Neoplasms Associate 12953101, 16685272, 18949710
Cachexia Associate 16495932
Cachexia Stimulate 16685272
Carcinogenesis Associate 12953101
Carcinoma Hepatocellular Associate 21397687
Cholangiocarcinoma Associate 18594538
Choriocarcinoma Associate 29073617
Colorectal Neoplasms Associate 34024817