Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
117145
Gene name Gene Name - the full gene name approved by the HGNC.
Thioesterase superfamily member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
THEM4
Synonyms (NCBI Gene) Gene synonyms aliases
CTMP
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory doma
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005171 hsa-miR-30a-5p pSILAC 18668040
MIRT005171 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT031745 hsa-miR-16-5p Proteomics 18668040
MIRT693161 hsa-miR-3609 HITS-CLIP 23313552
MIRT693162 hsa-miR-548ah-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19541650, 22309289, 24670654, 32814053
GO:0005739 Component Mitochondrion IDA 19604401
GO:0005743 Component Mitochondrial inner membrane IEA
GO:0005758 Component Mitochondrial intermembrane space IEA
GO:0005759 Component Mitochondrial matrix TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606388 17947 ENSG00000159445
Protein
UniProt ID Q5T1C6
Protein name Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4)
Protein function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1
PDB 4AE8 , 4GAH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03061 4HBT 148 223 Thioesterase superfamily Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:
Sequence
MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLL
FDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLG
FEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANL
NINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLY
SEATSLFIKLNPAKSLT
Sequence length 240
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Fatty acid elongation
Metabolic pathways
PI3K-Akt signaling pathway
  PIP3 activates AKT signaling
Activation of AKT2
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Mitochondrial Fatty Acid Beta-Oxidation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Kidney disease Chronic Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 29545352
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 27447863
Diabetes Mellitus Type 2 Associate 23673729
Lymphatic Metastasis Stimulate 27328758
Neoplasms Associate 17512909
Shock Septic Associate 39609718
Squamous Cell Carcinoma of Head and Neck Associate 27328758