Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
117
Gene name Gene Name - the full gene name approved by the HGNC.
ADCYAP receptor type I
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADCYAP1R1
Synonyms (NCBI Gene) Gene synonyms aliases
PAC1, PAC1R, PACAPR, PACAPRI
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT611488 hsa-miR-8485 HITS-CLIP 22927820
MIRT636742 hsa-miR-329-3p HITS-CLIP 22927820
MIRT636741 hsa-miR-362-3p HITS-CLIP 22927820
MIRT636740 hsa-miR-603 HITS-CLIP 22927820
MIRT614418 hsa-miR-4789-3p HITS-CLIP 22927820
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004999 Function Vasoactive intestinal polypeptide receptor activity IEA
GO:0005515 Function Protein binding IPI 17470806
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 7902709
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
102981 242 ENSG00000078549
Protein
UniProt ID P41586
Protein name Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)
Protein function G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (
PDB 2JOD , 3N94 , 6LPB , 6M1H , 6M1I , 6P9Y , 7JQD , 8E3X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM 51 137 Hormone receptor domain Family
PF00002 7tm_2 150 396 7 transmembrane receptor (Secretin family) Family
Tissue specificity TISSUE SPECIFICITY: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
Sequence
Sequence length 468
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Insulin secretion
Renin secretion
  G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
17387318
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 21059121 ClinVar
Mental Depression Mental Depression GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anxiety Associate 23328528, 24516127, 25918834, 31910434
Anxiety Disorders Associate 24516127, 31910434
Asthma Associate 23328528, 25918834
Behcet Syndrome Associate 17000890
Breast Neoplasms Associate 14742913, 37834358
Carcinoma Non Small Cell Lung Associate 30273693
Carotid Stenosis Associate 22372532
Colonic Neoplasms Associate 14742913
Colorectal Neoplasms Associate 14742913
Congenital contractural arachnodactyly Associate 22372532