Gene Gene information from NCBI Gene database.
Entrez ID 117
Gene name ADCYAP receptor type I
Gene symbol ADCYAP1R1
Synonyms (NCBI Gene)
PAC1PAC1RPACAPRPACAPRI
Chromosome 7
Chromosome location 7p14.3
Summary This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of
miRNA miRNA information provided by mirtarbase database.
495
miRTarBase ID miRNA Experiments Reference
MIRT611488 hsa-miR-8485 HITS-CLIP 22927820
MIRT636742 hsa-miR-329-3p HITS-CLIP 22927820
MIRT636741 hsa-miR-362-3p HITS-CLIP 22927820
MIRT636740 hsa-miR-603 HITS-CLIP 22927820
MIRT614418 hsa-miR-4789-3p HITS-CLIP 22927820
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0001634 Function Pituitary adenylate cyclase-activating polypeptide receptor activity IDA 36385145
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004999 Function Vasoactive intestinal polypeptide receptor activity IEA
GO:0005515 Function Protein binding IPI 17470806, 32296183, 32814053
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
102981 242 ENSG00000078549
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P41586
Protein name Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)
Protein function G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (
PDB 2JOD , 3N94 , 6LPB , 6M1H , 6M1I , 6P9Y , 7JQD , 8E3X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM 51 137 Hormone receptor domain Family
PF00002 7tm_2 150 396 7 transmembrane receptor (Secretin family) Family
Tissue specificity TISSUE SPECIFICITY: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
Sequence
Sequence length 468
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Insulin secretion
Renin secretion
  G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production