Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
117
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
ADCYAP receptor type I |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
ADCYAP1R1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
PAC1, PAC1R, PACAPR, PACAPRI |
Chromosome
Chromosome number
|
7 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7p14.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of |
UniProt ID |
P41586
|
Protein name |
Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) |
Protein function |
G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides ( |
PDB |
2JOD
,
3N94
,
6LPB
,
6M1H
,
6M1I
,
6P9Y
,
7JQD
,
8E3X
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02793
|
HRM |
51 → 137 |
Hormone receptor domain |
Family |
PF00002
|
7tm_2 |
150 → 396 |
7 transmembrane receptor (Secretin family) |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. |
Sequence |
|
Sequence length |
468 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
17387318 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Asthma |
Asthma |
|
21059121 |
ClinVar |
Mental Depression |
Mental Depression |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Anxiety |
Associate
|
23328528, 24516127, 25918834, 31910434 |
Anxiety Disorders |
Associate
|
24516127, 31910434 |
Asthma |
Associate
|
23328528, 25918834 |
Behcet Syndrome |
Associate
|
17000890 |
Breast Neoplasms |
Associate
|
14742913, 37834358 |
Carcinoma Non Small Cell Lung |
Associate
|
30273693 |
Carotid Stenosis |
Associate
|
22372532 |
Colonic Neoplasms |
Associate
|
14742913 |
Colorectal Neoplasms |
Associate
|
14742913 |
Congenital contractural arachnodactyly |
Associate
|
22372532 |
COVID 19 |
Associate
|
37834358 |
Dementia |
Associate
|
37834358 |
Diffuse Intrinsic Pontine Glioma |
Associate
|
39972389 |
Esophageal Neoplasms |
Associate
|
34329340 |
Gallbladder Neoplasms |
Associate
|
40527859 |
general anxiety disorder |
Associate
|
31910434 |
Heart Failure |
Associate
|
35409075 |
Lung Neoplasms |
Associate
|
11193832, 14742913, 22581436 |
Multiple Sclerosis |
Associate
|
39201536 |
Neoplasms |
Associate
|
31792942, 39972389 |
Neurologic Manifestations |
Associate
|
25680674 |
Pain |
Associate
|
27957625 |
Pediatric Obesity |
Associate
|
23280952 |
Stress Disorders Post Traumatic |
Associate
|
23280952, 23328528, 24516127, 25680674, 31910434 |
|