Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	116844
Gene name	Leucine rich alpha-2-glycoprotein 1
Gene symbol	LRG1
Synonyms (NCBI Gene)	HMFT1766LRG
Chromosome	19
Chromosome location	19p13.3
Summary	The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O`Donnell et al.

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006448	hsa-miR-335-5p	ImmunofluorescenceImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCRWestern blot	22382496
MIRT006448	hsa-miR-335-5p	ImmunofluorescenceImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCRWestern blot	22382496
MIRT006448	hsa-miR-335-5p	ImmunofluorescenceImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCRWestern blot	22382496
MIRT679358	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679357	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT679356	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT679355	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT679354	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT679352	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679353	hsa-miR-1976	HITS-CLIP	23824327
MIRT679351	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679350	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT679349	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT679348	hsa-miR-4279	HITS-CLIP	23824327
MIRT489906	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT489905	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT489904	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT679358	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679357	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT679356	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT679355	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT679354	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT679352	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679353	hsa-miR-1976	HITS-CLIP	23824327
MIRT679351	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679350	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT679349	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT679348	hsa-miR-4279	HITS-CLIP	23824327
MIRT489906	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT489905	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT489904	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT1117558	hsa-miR-1207-3p	CLIP-seq
MIRT1117559	hsa-miR-1224-3p	CLIP-seq
MIRT1117560	hsa-miR-1252	CLIP-seq
MIRT1117561	hsa-miR-197	CLIP-seq
MIRT1117562	hsa-miR-3194-3p	CLIP-seq
MIRT1117563	hsa-miR-3199	CLIP-seq
MIRT1117564	hsa-miR-3202	CLIP-seq
MIRT1117565	hsa-miR-431	CLIP-seq
MIRT1117566	hsa-miR-4426	CLIP-seq
MIRT1117567	hsa-miR-4454	CLIP-seq
MIRT1117568	hsa-miR-4476	CLIP-seq
MIRT1117569	hsa-miR-4533	CLIP-seq
MIRT1117570	hsa-miR-4647	CLIP-seq
MIRT1117571	hsa-miR-4662a-5p	CLIP-seq
MIRT1117572	hsa-miR-4662b	CLIP-seq
MIRT1117573	hsa-miR-4716-5p	CLIP-seq
MIRT1117574	hsa-miR-5096	CLIP-seq
MIRT1117575	hsa-miR-552	CLIP-seq
MIRT1117576	hsa-miR-564	CLIP-seq
MIRT1117577	hsa-miR-764	CLIP-seq
MIRT2033230	hsa-miR-1228	CLIP-seq
MIRT2033231	hsa-miR-1281	CLIP-seq
MIRT2033232	hsa-miR-1305	CLIP-seq
MIRT2033233	hsa-miR-145	CLIP-seq
MIRT2033234	hsa-miR-150	CLIP-seq
MIRT2033235	hsa-miR-3189-3p	CLIP-seq
MIRT1117563	hsa-miR-3199	CLIP-seq
MIRT2033236	hsa-miR-3616-3p	CLIP-seq
MIRT2033237	hsa-miR-4328	CLIP-seq
MIRT2033238	hsa-miR-4477a	CLIP-seq
MIRT2033239	hsa-miR-4735-5p	CLIP-seq
MIRT2033240	hsa-miR-4775	CLIP-seq
MIRT2033241	hsa-miR-4794	CLIP-seq
MIRT2033242	hsa-miR-498	CLIP-seq
MIRT1117576	hsa-miR-564	CLIP-seq
MIRT2033243	hsa-miR-590-3p	CLIP-seq
MIRT2033244	hsa-miR-635	CLIP-seq
MIRT1117577	hsa-miR-764	CLIP-seq
MIRT2033234	hsa-miR-150	CLIP-seq
MIRT1117562	hsa-miR-3194-3p	CLIP-seq
MIRT2263530	hsa-miR-3672	CLIP-seq
MIRT1117565	hsa-miR-431	CLIP-seq
MIRT2033239	hsa-miR-4735-5p	CLIP-seq
MIRT2033240	hsa-miR-4775	CLIP-seq
MIRT2033241	hsa-miR-4794	CLIP-seq
MIRT1117576	hsa-miR-564	CLIP-seq
MIRT2033243	hsa-miR-590-3p	CLIP-seq
MIRT1117576	hsa-miR-564	CLIP-seq
MIRT1117563	hsa-miR-3199	CLIP-seq
MIRT2033241	hsa-miR-4794	CLIP-seq
MIRT1117575	hsa-miR-552	CLIP-seq
MIRT1117577	hsa-miR-764	CLIP-seq
MIRT2033231	hsa-miR-1281	CLIP-seq
MIRT2033234	hsa-miR-150	CLIP-seq
MIRT2562850	hsa-miR-24	CLIP-seq
MIRT2562851	hsa-miR-411	CLIP-seq
MIRT2562852	hsa-miR-4284	CLIP-seq
MIRT2033239	hsa-miR-4735-5p	CLIP-seq
MIRT2033240	hsa-miR-4775	CLIP-seq
MIRT2033241	hsa-miR-4794	CLIP-seq
MIRT1117576	hsa-miR-564	CLIP-seq
MIRT2033243	hsa-miR-590-3p	CLIP-seq
MIRT2562850	hsa-miR-24	CLIP-seq
MIRT2562852	hsa-miR-4284	CLIP-seq
MIRT2033239	hsa-miR-4735-5p	CLIP-seq
MIRT2033240	hsa-miR-4775	CLIP-seq
MIRT2033241	hsa-miR-4794	CLIP-seq
MIRT1117576	hsa-miR-564	CLIP-seq
MIRT2033243	hsa-miR-590-3p	CLIP-seq

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IEA
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IMP	23868260
GO:0005114	Function	Type II transforming growth factor beta receptor binding	IPI	23868260
GO:0005160	Function	Transforming growth factor beta receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	23868260, 28514442, 33961781
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	12223515, 14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	20363744
GO:0005615	Component	Extracellular space	IEA
GO:0006955	Process	Immune response	IBA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IBA
GO:0009617	Process	Response to bacterium	IEA
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IDA	32887674
GO:0010838	Process	Positive regulation of keratinocyte proliferation	IEA
GO:0010838	Process	Positive regulation of keratinocyte proliferation	IMP	32887674
GO:0016020	Component	Membrane	NAS	3856868
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IDA	23868260, 32887674
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0034713	Function	Type I transforming growth factor beta receptor binding	IPI	23868260
GO:0035313	Process	Wound healing, spreading of epidermal cells	IEA
GO:0035313	Process	Wound healing, spreading of epidermal cells	IMP	32887674
GO:0035580	Component	Specific granule lumen	TAS
GO:0045766	Process	Positive regulation of angiogenesis	IEA
GO:0045766	Process	Positive regulation of angiogenesis	IMP	32887674
GO:0045766	Process	Positive regulation of angiogenesis	IMP	23868260
GO:0050431	Function	Transforming growth factor beta binding	IBA
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0051546	Process	Keratinocyte migration	IEA
GO:0051546	Process	Keratinocyte migration	IMP	32887674
GO:0060054	Process	Positive regulation of epithelial cell proliferation involved in wound healing	IEA
GO:0060054	Process	Positive regulation of epithelial cell proliferation involved in wound healing	IMP	32887674
GO:0061756	Process	Leukocyte adhesion to vascular endothelial cell	IEA
GO:0061756	Process	Leukocyte adhesion to vascular endothelial cell	IMP	32887674
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
611289	29480	ENSG00000171236

P02750

Protein name

Leucine-rich alpha-2-glycoprotein (LRG)

PDB

7Q4Q , 8H24

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	71 → 128	Leucine rich repeat	Repeat
PF13855	LRR_8	116 → 176	Leucine rich repeat	Repeat
PF13855	LRR_8	168 → 224	Leucine rich repeat	Repeat
PF13855	LRR_8	212 → 272	Leucine rich repeat	Repeat
PF13855	LRR_8	236 → 285	Leucine rich repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Plasma.

Sequence

MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPA
EIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRV
LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP
PGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRY
LFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNP
WICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ

Sequence length

347

Interactions

View interactions

	Reactome
			Neutrophil degranulation

LRG1 (leucine rich alpha-2-glycoprotein 1)