PHACTR3 (phosphatase and actin regulator 3)

Gene

• Entrez ID: 116154
• Gene name: Phosphatase and actin regulator 3
• Gene symbol: PHACTR3
• Synonyms (NCBI Gene): C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ
• Chromosome: 20
• Chromosome location: 20q13.32-q13.33
• Summary: This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052804	hsa-miR-3181	CLASH	23622248
MIRT1228974	hsa-miR-200b	CLIP-seq
MIRT1228975	hsa-miR-200c	CLIP-seq
MIRT1228976	hsa-miR-3117-5p	CLIP-seq
MIRT1228977	hsa-miR-425	CLIP-seq
MIRT1228978	hsa-miR-429	CLIP-seq
MIRT1228979	hsa-miR-4717-3p	CLIP-seq
MIRT1228980	hsa-miR-4724-5p	CLIP-seq
MIRT2592435	hsa-miR-1247	CLIP-seq
MIRT2592436	hsa-miR-1252	CLIP-seq
MIRT2592437	hsa-miR-1324	CLIP-seq
MIRT2592438	hsa-miR-136	CLIP-seq
MIRT2592439	hsa-miR-298	CLIP-seq
MIRT1228976	hsa-miR-3117-5p	CLIP-seq
MIRT2592440	hsa-miR-3158-5p	CLIP-seq
MIRT2592441	hsa-miR-3192	CLIP-seq
MIRT2592442	hsa-miR-3607-3p	CLIP-seq
MIRT2592443	hsa-miR-377	CLIP-seq
MIRT2592444	hsa-miR-4257	CLIP-seq
MIRT2592445	hsa-miR-4418	CLIP-seq
MIRT2592446	hsa-miR-4476	CLIP-seq
MIRT2592447	hsa-miR-4533	CLIP-seq
MIRT2592448	hsa-miR-4691-5p	CLIP-seq
MIRT2592449	hsa-miR-4709-5p	CLIP-seq
MIRT2592450	hsa-miR-4710	CLIP-seq
MIRT1228979	hsa-miR-4717-3p	CLIP-seq
MIRT2592451	hsa-miR-4792	CLIP-seq
MIRT2592452	hsa-miR-483-3p	CLIP-seq
MIRT2592453	hsa-miR-488	CLIP-seq
MIRT2592454	hsa-miR-509-3-5p	CLIP-seq
MIRT2592455	hsa-miR-509-5p	CLIP-seq
MIRT2592456	hsa-miR-548an	CLIP-seq
MIRT2592457	hsa-miR-595	CLIP-seq
MIRT2592458	hsa-miR-596	CLIP-seq
MIRT2592459	hsa-miR-624	CLIP-seq
MIRT2592460	hsa-miR-661	CLIP-seq
MIRT2592461	hsa-miR-885-5p	CLIP-seq
MIRT2592436	hsa-miR-1252	CLIP-seq
MIRT2592437	hsa-miR-1324	CLIP-seq
MIRT1228976	hsa-miR-3117-5p	CLIP-seq
MIRT2687798	hsa-miR-3657	CLIP-seq
MIRT2592443	hsa-miR-377	CLIP-seq
MIRT2687799	hsa-miR-3909	CLIP-seq
MIRT2687800	hsa-miR-409-5p	CLIP-seq
MIRT2592446	hsa-miR-4476	CLIP-seq
MIRT2592447	hsa-miR-4533	CLIP-seq
MIRT2687801	hsa-miR-4669	CLIP-seq
MIRT2592449	hsa-miR-4709-5p	CLIP-seq
MIRT1228979	hsa-miR-4717-3p	CLIP-seq
MIRT2592452	hsa-miR-483-3p	CLIP-seq
MIRT2592457	hsa-miR-595	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0004864	Function	Protein phosphatase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0016363	Component	Nuclear matrix	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA

Other IDs

• MIM: 608725
• HGNC: 15833
• e!Ensembl: ENSG00000087495

Protein

• UniProt ID: Q96KR7
• Protein name: Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02755	RPEL	440 → 463	RPEL repeat	Disordered

• Tissue specificity: TISSUE SPECIFICITY: Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells.
• Sequence:

  MAASEDGSGCLVSRGRSQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTP
  PVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQD
  AESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDA
  AKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPK
  ASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRA
  LATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESE
  ENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRN
  IFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLT
  RKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYK
  SNEMEVHASSKHLTRFHRP

• Sequence length: 559

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs138964292	RCV005932240

Associations from Text Mining
Disease Name	Relationship Type	References
Inflammatory Bowel Diseases	Associate	37473877
Neoplasms Radiation Induced	Associate	26681684
Radiation Fibrosis Syndrome	Associate	26681684
Urinary Bladder Neoplasms	Stimulate	35123558