Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	115426
Gene name	Ubiquitin like with PHD and ring finger domains 2
Gene symbol	UHRF2
Synonyms (NCBI Gene)	NIRFRNF107TDRD23URF2
Chromosome	9
Chromosome location	9p24.1
Summary	This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded prote

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004321	hsa-let-7a-5p	qRT-PCRWestern blot	19818775
MIRT004321	hsa-let-7a-5p	Luciferase reporter assay	19818775
MIRT018641	hsa-miR-335-5p	Microarray	18185580
MIRT028675	hsa-miR-30a-5p	Proteomics	18668040
MIRT046615	hsa-miR-222-3p	CLASH	23622248
MIRT1474490	hsa-let-7a	CLIP-seq
MIRT1474491	hsa-let-7b	CLIP-seq
MIRT1474492	hsa-let-7c	CLIP-seq
MIRT1474493	hsa-let-7d	CLIP-seq
MIRT1474494	hsa-let-7e	CLIP-seq
MIRT1474495	hsa-let-7f	CLIP-seq
MIRT1474496	hsa-let-7g	CLIP-seq
MIRT1474497	hsa-let-7i	CLIP-seq
MIRT1474498	hsa-miR-1184	CLIP-seq
MIRT1474499	hsa-miR-1200	CLIP-seq
MIRT1474500	hsa-miR-1205	CLIP-seq
MIRT1474501	hsa-miR-130a	CLIP-seq
MIRT1474502	hsa-miR-130b	CLIP-seq
MIRT1474503	hsa-miR-1323	CLIP-seq
MIRT1474504	hsa-miR-196a	CLIP-seq
MIRT1474505	hsa-miR-196b	CLIP-seq
MIRT1474506	hsa-miR-19a	CLIP-seq
MIRT1474507	hsa-miR-19b	CLIP-seq
MIRT1474508	hsa-miR-202	CLIP-seq
MIRT1474509	hsa-miR-301a	CLIP-seq
MIRT1474510	hsa-miR-301b	CLIP-seq
MIRT1474511	hsa-miR-302a	CLIP-seq
MIRT1474512	hsa-miR-302b	CLIP-seq
MIRT1474513	hsa-miR-302c	CLIP-seq
MIRT1474514	hsa-miR-302d	CLIP-seq
MIRT1474515	hsa-miR-302e	CLIP-seq
MIRT1474516	hsa-miR-3065-3p	CLIP-seq
MIRT1474517	hsa-miR-3117-5p	CLIP-seq
MIRT1474518	hsa-miR-3145-3p	CLIP-seq
MIRT1474519	hsa-miR-3158-5p	CLIP-seq
MIRT1474520	hsa-miR-3666	CLIP-seq
MIRT1474521	hsa-miR-371b-5p	CLIP-seq
MIRT1474522	hsa-miR-372	CLIP-seq
MIRT1474523	hsa-miR-373	CLIP-seq
MIRT1474524	hsa-miR-4269	CLIP-seq
MIRT1474525	hsa-miR-4286	CLIP-seq
MIRT1474526	hsa-miR-4295	CLIP-seq
MIRT1474527	hsa-miR-4299	CLIP-seq
MIRT1474528	hsa-miR-4324	CLIP-seq
MIRT1474529	hsa-miR-4458	CLIP-seq
MIRT1474530	hsa-miR-4495	CLIP-seq
MIRT1474531	hsa-miR-4500	CLIP-seq
MIRT1474532	hsa-miR-454	CLIP-seq
MIRT1474533	hsa-miR-455-3p	CLIP-seq
MIRT1474534	hsa-miR-4645-5p	CLIP-seq
MIRT1474535	hsa-miR-4652-3p	CLIP-seq
MIRT1474536	hsa-miR-4659a-3p	CLIP-seq
MIRT1474537	hsa-miR-4659b-3p	CLIP-seq
MIRT1474538	hsa-miR-4673	CLIP-seq
MIRT1474539	hsa-miR-4684-3p	CLIP-seq
MIRT1474540	hsa-miR-4687-5p	CLIP-seq
MIRT1474541	hsa-miR-4703-3p	CLIP-seq
MIRT1474542	hsa-miR-4710	CLIP-seq
MIRT1474543	hsa-miR-4760-5p	CLIP-seq
MIRT1474544	hsa-miR-4792	CLIP-seq
MIRT1474545	hsa-miR-518a-5p	CLIP-seq
MIRT1474546	hsa-miR-519a	CLIP-seq
MIRT1474547	hsa-miR-519b-3p	CLIP-seq
MIRT1474548	hsa-miR-519c-3p	CLIP-seq
MIRT1474549	hsa-miR-520a-3p	CLIP-seq
MIRT1474550	hsa-miR-520b	CLIP-seq
MIRT1474551	hsa-miR-520c-3p	CLIP-seq
MIRT1474552	hsa-miR-520d-3p	CLIP-seq
MIRT1474553	hsa-miR-520e	CLIP-seq
MIRT1474554	hsa-miR-527	CLIP-seq
MIRT1474555	hsa-miR-544b	CLIP-seq
MIRT1474556	hsa-miR-548aa	CLIP-seq
MIRT1474557	hsa-miR-548b-3p	CLIP-seq
MIRT1474558	hsa-miR-548o	CLIP-seq
MIRT1474559	hsa-miR-660	CLIP-seq
MIRT1474560	hsa-miR-98	CLIP-seq
MIRT2142807	hsa-miR-1290	CLIP-seq
MIRT2142808	hsa-miR-1827	CLIP-seq
MIRT2142809	hsa-miR-2682	CLIP-seq
MIRT2142810	hsa-miR-3122	CLIP-seq
MIRT2142811	hsa-miR-3129-3p	CLIP-seq
MIRT2142812	hsa-miR-3167	CLIP-seq
MIRT2142813	hsa-miR-34a	CLIP-seq
MIRT2142814	hsa-miR-34c-5p	CLIP-seq
MIRT2142815	hsa-miR-3612	CLIP-seq
MIRT2142816	hsa-miR-3681	CLIP-seq
MIRT2142817	hsa-miR-3689a-3p	CLIP-seq
MIRT2142818	hsa-miR-3689c	CLIP-seq
MIRT2142819	hsa-miR-3913-5p	CLIP-seq
MIRT2142820	hsa-miR-4282	CLIP-seq
MIRT2142821	hsa-miR-4302	CLIP-seq
MIRT2142822	hsa-miR-433	CLIP-seq
MIRT2142823	hsa-miR-449a	CLIP-seq
MIRT2142824	hsa-miR-449b	CLIP-seq
MIRT2142825	hsa-miR-449c	CLIP-seq
MIRT1474533	hsa-miR-455-3p	CLIP-seq
MIRT1474536	hsa-miR-4659a-3p	CLIP-seq
MIRT1474537	hsa-miR-4659b-3p	CLIP-seq
MIRT2142826	hsa-miR-4728-5p	CLIP-seq
MIRT2142827	hsa-miR-513a-3p	CLIP-seq
MIRT1474545	hsa-miR-518a-5p	CLIP-seq
MIRT1474554	hsa-miR-527	CLIP-seq
MIRT2142828	hsa-miR-650	CLIP-seq
MIRT2142829	hsa-miR-876-5p	CLIP-seq
MIRT2363167	hsa-miR-22	CLIP-seq
MIRT2363168	hsa-miR-299-3p	CLIP-seq
MIRT2363169	hsa-miR-3153	CLIP-seq
MIRT2363170	hsa-miR-3159	CLIP-seq
MIRT2363171	hsa-miR-3977	CLIP-seq
MIRT2363172	hsa-miR-4491	CLIP-seq
MIRT2363173	hsa-miR-4648	CLIP-seq
MIRT2363174	hsa-miR-4654	CLIP-seq
MIRT2363175	hsa-miR-4657	CLIP-seq
MIRT2363176	hsa-miR-4668-5p	CLIP-seq
MIRT2363177	hsa-miR-4769-5p	CLIP-seq
MIRT2363178	hsa-miR-583	CLIP-seq
MIRT2462889	hsa-miR-3646	CLIP-seq
MIRT2462890	hsa-miR-3662	CLIP-seq
MIRT1474525	hsa-miR-4286	CLIP-seq
MIRT1474536	hsa-miR-4659a-3p	CLIP-seq
MIRT1474537	hsa-miR-4659b-3p	CLIP-seq
MIRT2462891	hsa-miR-649	CLIP-seq
MIRT1474559	hsa-miR-660	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000792	Component	Heterochromatin	IEA
GO:0000792	Component	Heterochromatin	ISS
GO:0003677	Function	DNA binding	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	14741369
GO:0005515	Function	Protein binding	IPI	12176013, 15178429, 21952639, 32296183
GO:0005634	Component	Nucleus	IDA	12176013
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005721	Component	Pericentric heterochromatin	IDA	27129234
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	27129234
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IDA	14741369
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016925	Process	Protein sumoylation	TAS
GO:0019789	Function	SUMO transferase activity	EXP	22467880, 23404503
GO:0030154	Process	Cell differentiation	IEP	12176013
GO:0042393	Function	Histone binding	IEA
GO:0042393	Function	Histone binding	ISS
GO:0044027	Process	Negative regulation of gene expression via chromosomal CpG island methylation	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051726	Process	Regulation of cell cycle	IDA	15178429
GO:0051726	Process	Regulation of cell cycle	TAS	14741369
GO:0051865	Process	Protein autoubiquitination	IDA	14741369
GO:0051865	Process	Protein autoubiquitination	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	27129234
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	14741369
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0062072	Function	Histone H3K9me2/3 reader activity	TAS	27129234

MIM	HGNC	e!Ensembl
615211	12557	ENSG00000147854

Q96PU4

Protein name

E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-

Protein function

E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC

PDB

1WY8 , 1Z6U , 2E6S , 3OLN , 4PW5 , 4PW6 , 4PW7 , 4TVR , 5YCO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00240	ubiquitin	3 → 76	Ubiquitin family	Domain
PF12148	TTD	124 → 312	Tandem tudor domain within UHRF1	Domain
PF00628	PHD	346 → 395	PHD-finger	Domain
PF02182	SAD_SRA	446 → 616	SAD/SRA domain	Domain

Sequence

MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFD
YDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLI
DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKH
KSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWN
ELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKII
SVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQL
LCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSAST
ESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHG
RSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALN
CDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSS
HGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSG
TTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEG
PNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYI
MIPNEILQTLLDLFFPGYSKGR

Sequence length

802

Interactions

View interactions

	Reactome
			SUMOylation of transcription cofactors

UHRF2 (ubiquitin like with PHD and ring finger domains 2)