Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	115362
Gene name	Guanylate binding protein 5
Gene symbol	GBP5
Synonyms (NCBI Gene)	GBP-5
Chromosome	1
Chromosome location	1p22.2
Summary	This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants

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Show/Hide all (236)

miRTarBase ID	miRNA	Experiments
MIRT1014074	hsa-miR-1178	CLIP-seq
MIRT1014075	hsa-miR-147	CLIP-seq
MIRT1014076	hsa-miR-1976	CLIP-seq
MIRT1014077	hsa-miR-370	CLIP-seq
MIRT1014078	hsa-miR-3911	CLIP-seq
MIRT1014079	hsa-miR-644	CLIP-seq
MIRT1014080	hsa-miR-663b	CLIP-seq
MIRT1014081	hsa-miR-767-3p	CLIP-seq
MIRT1014082	hsa-miR-155	CLIP-seq
MIRT1014083	hsa-miR-3155	CLIP-seq
MIRT1014084	hsa-miR-3155b	CLIP-seq
MIRT1014085	hsa-miR-3670	CLIP-seq
MIRT1014086	hsa-miR-3689d	CLIP-seq
MIRT1014087	hsa-miR-4459	CLIP-seq
MIRT1014088	hsa-miR-4633-3p	CLIP-seq
MIRT1014089	hsa-miR-484	CLIP-seq
MIRT2000359	hsa-miR-3190	CLIP-seq
MIRT2000360	hsa-miR-3202	CLIP-seq
MIRT2000361	hsa-miR-3677-3p	CLIP-seq
MIRT2000362	hsa-miR-4270	CLIP-seq
MIRT2000363	hsa-miR-4441	CLIP-seq
MIRT2000364	hsa-miR-4533	CLIP-seq
MIRT2000365	hsa-miR-4642	CLIP-seq
MIRT2000366	hsa-miR-4711-5p	CLIP-seq
MIRT1014074	hsa-miR-1178	CLIP-seq
MIRT1014075	hsa-miR-147	CLIP-seq
MIRT1014076	hsa-miR-1976	CLIP-seq
MIRT1014083	hsa-miR-3155	CLIP-seq
MIRT1014084	hsa-miR-3155b	CLIP-seq
MIRT2000359	hsa-miR-3190	CLIP-seq
MIRT2000360	hsa-miR-3202	CLIP-seq
MIRT1014085	hsa-miR-3670	CLIP-seq
MIRT2000361	hsa-miR-3677-3p	CLIP-seq
MIRT1014086	hsa-miR-3689d	CLIP-seq
MIRT1014077	hsa-miR-370	CLIP-seq
MIRT1014078	hsa-miR-3911	CLIP-seq
MIRT2000362	hsa-miR-4270	CLIP-seq
MIRT2000363	hsa-miR-4441	CLIP-seq
MIRT1014087	hsa-miR-4459	CLIP-seq
MIRT2000364	hsa-miR-4533	CLIP-seq
MIRT1014088	hsa-miR-4633-3p	CLIP-seq
MIRT2000365	hsa-miR-4642	CLIP-seq
MIRT2000366	hsa-miR-4711-5p	CLIP-seq
MIRT2450139	hsa-miR-4743	CLIP-seq
MIRT1014089	hsa-miR-484	CLIP-seq
MIRT1014079	hsa-miR-644	CLIP-seq
MIRT1014080	hsa-miR-663b	CLIP-seq
MIRT1014081	hsa-miR-767-3p	CLIP-seq
MIRT1014074	hsa-miR-1178	CLIP-seq
MIRT2537672	hsa-miR-1184	CLIP-seq
MIRT2537673	hsa-miR-1205	CLIP-seq
MIRT2537674	hsa-miR-1208	CLIP-seq
MIRT2537675	hsa-miR-1227	CLIP-seq
MIRT2537676	hsa-miR-1263	CLIP-seq
MIRT2537677	hsa-miR-1265	CLIP-seq
MIRT2537678	hsa-miR-1280	CLIP-seq
MIRT2537679	hsa-miR-1286	CLIP-seq
MIRT2537680	hsa-miR-1301	CLIP-seq
MIRT2537681	hsa-miR-138	CLIP-seq
MIRT2537682	hsa-miR-146b-3p	CLIP-seq
MIRT1014075	hsa-miR-147	CLIP-seq
MIRT1014082	hsa-miR-155	CLIP-seq
MIRT2537683	hsa-miR-15a	CLIP-seq
MIRT2537684	hsa-miR-15b	CLIP-seq
MIRT2537685	hsa-miR-16	CLIP-seq
MIRT2537686	hsa-miR-1913	CLIP-seq
MIRT2537687	hsa-miR-195	CLIP-seq
MIRT1014076	hsa-miR-1976	CLIP-seq
MIRT2537688	hsa-miR-21	CLIP-seq
MIRT2537689	hsa-miR-216b	CLIP-seq
MIRT2537690	hsa-miR-219-5p	CLIP-seq
MIRT2537691	hsa-miR-22	CLIP-seq
MIRT2537692	hsa-miR-296-3p	CLIP-seq
MIRT2537693	hsa-miR-3119	CLIP-seq
MIRT2537694	hsa-miR-3125	CLIP-seq
MIRT2537695	hsa-miR-3130-5p	CLIP-seq
MIRT2537696	hsa-miR-3143	CLIP-seq
MIRT2537697	hsa-miR-3144-3p	CLIP-seq
MIRT1014083	hsa-miR-3155	CLIP-seq
MIRT1014084	hsa-miR-3155b	CLIP-seq
MIRT2537698	hsa-miR-3158-5p	CLIP-seq
MIRT2537699	hsa-miR-3166	CLIP-seq
MIRT2537700	hsa-miR-3173-5p	CLIP-seq
MIRT2537701	hsa-miR-3182	CLIP-seq
MIRT2537702	hsa-miR-3185	CLIP-seq
MIRT2537703	hsa-miR-3187-3p	CLIP-seq
MIRT2000359	hsa-miR-3190	CLIP-seq
MIRT2537704	hsa-miR-3192	CLIP-seq
MIRT2000360	hsa-miR-3202	CLIP-seq
MIRT2537705	hsa-miR-320a	CLIP-seq
MIRT2537706	hsa-miR-320b	CLIP-seq
MIRT2537707	hsa-miR-320c	CLIP-seq
MIRT2537708	hsa-miR-320d	CLIP-seq
MIRT2537709	hsa-miR-324-3p	CLIP-seq
MIRT2537710	hsa-miR-361-3p	CLIP-seq
MIRT2537711	hsa-miR-3620	CLIP-seq
MIRT1014085	hsa-miR-3670	CLIP-seq
MIRT2537712	hsa-miR-3673	CLIP-seq
MIRT2537713	hsa-miR-3675-3p	CLIP-seq
MIRT2000361	hsa-miR-3677-3p	CLIP-seq
MIRT2537714	hsa-miR-3689a-3p	CLIP-seq
MIRT2537715	hsa-miR-3689c	CLIP-seq
MIRT1014086	hsa-miR-3689d	CLIP-seq
MIRT2537716	hsa-miR-3692	CLIP-seq
MIRT1014077	hsa-miR-370	CLIP-seq
MIRT2537717	hsa-miR-383	CLIP-seq
MIRT1014078	hsa-miR-3911	CLIP-seq
MIRT2537718	hsa-miR-3916	CLIP-seq
MIRT2537719	hsa-miR-3943	CLIP-seq
MIRT2537720	hsa-miR-410	CLIP-seq
MIRT2537721	hsa-miR-424	CLIP-seq
MIRT2537722	hsa-miR-4252	CLIP-seq
MIRT2537723	hsa-miR-4261	CLIP-seq
MIRT2000362	hsa-miR-4270	CLIP-seq
MIRT2537724	hsa-miR-4293	CLIP-seq
MIRT2537725	hsa-miR-4313	CLIP-seq
MIRT2537726	hsa-miR-4418	CLIP-seq
MIRT2537727	hsa-miR-4425	CLIP-seq
MIRT2537728	hsa-miR-4429	CLIP-seq
MIRT2537729	hsa-miR-4436b-5p	CLIP-seq
MIRT2000363	hsa-miR-4441	CLIP-seq
MIRT2537730	hsa-miR-4453	CLIP-seq
MIRT1014087	hsa-miR-4459	CLIP-seq
MIRT2537731	hsa-miR-4480	CLIP-seq
MIRT2537732	hsa-miR-4482	CLIP-seq
MIRT2537733	hsa-miR-4490	CLIP-seq
MIRT2537734	hsa-miR-4496	CLIP-seq
MIRT2537735	hsa-miR-4524	CLIP-seq
MIRT2537736	hsa-miR-4529-5p	CLIP-seq
MIRT2000364	hsa-miR-4533	CLIP-seq
MIRT2537737	hsa-miR-4538	CLIP-seq
MIRT1014088	hsa-miR-4633-3p	CLIP-seq
MIRT2000365	hsa-miR-4642	CLIP-seq
MIRT2537738	hsa-miR-4645-3p	CLIP-seq
MIRT2537739	hsa-miR-4660	CLIP-seq
MIRT2537740	hsa-miR-4684-5p	CLIP-seq
MIRT2000366	hsa-miR-4711-5p	CLIP-seq
MIRT2537741	hsa-miR-4717-5p	CLIP-seq
MIRT2537742	hsa-miR-4719	CLIP-seq
MIRT2537743	hsa-miR-4722-5p	CLIP-seq
MIRT2537744	hsa-miR-4728-5p	CLIP-seq
MIRT2450139	hsa-miR-4743	CLIP-seq
MIRT2537745	hsa-miR-4747-5p	CLIP-seq
MIRT2537746	hsa-miR-4764-5p	CLIP-seq
MIRT2537747	hsa-miR-4768-5p	CLIP-seq
MIRT2537748	hsa-miR-4771	CLIP-seq
MIRT2537749	hsa-miR-4782-3p	CLIP-seq
MIRT2537750	hsa-miR-4793-5p	CLIP-seq
MIRT2537751	hsa-miR-4795-3p	CLIP-seq
MIRT2537752	hsa-miR-4796-5p	CLIP-seq
MIRT1014089	hsa-miR-484	CLIP-seq
MIRT2537753	hsa-miR-488	CLIP-seq
MIRT2537754	hsa-miR-494	CLIP-seq
MIRT2537755	hsa-miR-497	CLIP-seq
MIRT2537756	hsa-miR-503	CLIP-seq
MIRT2537757	hsa-miR-5047	CLIP-seq
MIRT2537758	hsa-miR-509-3-5p	CLIP-seq
MIRT2537759	hsa-miR-509-5p	CLIP-seq
MIRT2537760	hsa-miR-543	CLIP-seq
MIRT2537761	hsa-miR-544b	CLIP-seq
MIRT2537762	hsa-miR-587	CLIP-seq
MIRT2537763	hsa-miR-590-5p	CLIP-seq
MIRT2537764	hsa-miR-596	CLIP-seq
MIRT2537765	hsa-miR-642b	CLIP-seq
MIRT1014079	hsa-miR-644	CLIP-seq
MIRT2537766	hsa-miR-646	CLIP-seq
MIRT1014080	hsa-miR-663b	CLIP-seq
MIRT2537767	hsa-miR-671-5p	CLIP-seq
MIRT1014081	hsa-miR-767-3p	CLIP-seq
MIRT2537768	hsa-miR-874	CLIP-seq
MIRT1014074	hsa-miR-1178	CLIP-seq
MIRT2537672	hsa-miR-1184	CLIP-seq
MIRT2537673	hsa-miR-1205	CLIP-seq
MIRT2537677	hsa-miR-1265	CLIP-seq
MIRT2537679	hsa-miR-1286	CLIP-seq
MIRT2537680	hsa-miR-1301	CLIP-seq
MIRT2537681	hsa-miR-138	CLIP-seq
MIRT2537682	hsa-miR-146b-3p	CLIP-seq
MIRT1014075	hsa-miR-147	CLIP-seq
MIRT1014082	hsa-miR-155	CLIP-seq
MIRT2537686	hsa-miR-1913	CLIP-seq
MIRT1014076	hsa-miR-1976	CLIP-seq
MIRT2537688	hsa-miR-21	CLIP-seq
MIRT2537689	hsa-miR-216b	CLIP-seq
MIRT2537691	hsa-miR-22	CLIP-seq
MIRT2537694	hsa-miR-3125	CLIP-seq
MIRT1014083	hsa-miR-3155	CLIP-seq
MIRT1014084	hsa-miR-3155b	CLIP-seq
MIRT2537700	hsa-miR-3173-5p	CLIP-seq
MIRT2537701	hsa-miR-3182	CLIP-seq
MIRT2537702	hsa-miR-3185	CLIP-seq
MIRT2537703	hsa-miR-3187-3p	CLIP-seq
MIRT2000359	hsa-miR-3190	CLIP-seq
MIRT2537704	hsa-miR-3192	CLIP-seq
MIRT2000360	hsa-miR-3202	CLIP-seq
MIRT2537709	hsa-miR-324-3p	CLIP-seq
MIRT2537710	hsa-miR-361-3p	CLIP-seq
MIRT2537711	hsa-miR-3620	CLIP-seq
MIRT1014085	hsa-miR-3670	CLIP-seq
MIRT2000361	hsa-miR-3677-3p	CLIP-seq
MIRT2537714	hsa-miR-3689a-3p	CLIP-seq
MIRT2537715	hsa-miR-3689c	CLIP-seq
MIRT1014086	hsa-miR-3689d	CLIP-seq
MIRT1014077	hsa-miR-370	CLIP-seq
MIRT1014078	hsa-miR-3911	CLIP-seq
MIRT2537718	hsa-miR-3916	CLIP-seq
MIRT2537719	hsa-miR-3943	CLIP-seq
MIRT2537720	hsa-miR-410	CLIP-seq
MIRT2000362	hsa-miR-4270	CLIP-seq
MIRT2537725	hsa-miR-4313	CLIP-seq
MIRT2537726	hsa-miR-4418	CLIP-seq
MIRT2000363	hsa-miR-4441	CLIP-seq
MIRT1014087	hsa-miR-4459	CLIP-seq
MIRT2537733	hsa-miR-4490	CLIP-seq
MIRT2537736	hsa-miR-4529-5p	CLIP-seq
MIRT2000364	hsa-miR-4533	CLIP-seq
MIRT1014088	hsa-miR-4633-3p	CLIP-seq
MIRT2000365	hsa-miR-4642	CLIP-seq
MIRT2537739	hsa-miR-4660	CLIP-seq
MIRT2000366	hsa-miR-4711-5p	CLIP-seq
MIRT2537742	hsa-miR-4719	CLIP-seq
MIRT2537743	hsa-miR-4722-5p	CLIP-seq
MIRT2537744	hsa-miR-4728-5p	CLIP-seq
MIRT2450139	hsa-miR-4743	CLIP-seq
MIRT2537746	hsa-miR-4764-5p	CLIP-seq
MIRT1014089	hsa-miR-484	CLIP-seq
MIRT2537757	hsa-miR-5047	CLIP-seq
MIRT2537758	hsa-miR-509-3-5p	CLIP-seq
MIRT2537759	hsa-miR-509-5p	CLIP-seq
MIRT2537762	hsa-miR-587	CLIP-seq
MIRT2537763	hsa-miR-590-5p	CLIP-seq
MIRT2537765	hsa-miR-642b	CLIP-seq
MIRT1014079	hsa-miR-644	CLIP-seq
MIRT1014080	hsa-miR-663b	CLIP-seq
MIRT1014081	hsa-miR-767-3p	CLIP-seq
MIRT2537768	hsa-miR-874	CLIP-seq

Show/Hide all (58)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	31091448
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0002218	Process	Activation of innate immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	26996307, 33876762
GO:0003924	Function	GTPase activity	IEA
GO:0004866	Function	Endopeptidase inhibitor activity	IDA	31091448
GO:0005515	Function	Protein binding	IPI	21151871, 22461501, 28514442, 33961781
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	17266443
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	26996307, 31091448
GO:0005794	Component	Golgi apparatus	IDA	17266443, 21151871
GO:0005794	Component	Golgi apparatus	IEA
GO:0006605	Process	Protein targeting	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IEA
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IMP	22461501
GO:0032741	Process	Positive regulation of interleukin-18 production	IEA
GO:0032741	Process	Positive regulation of interleukin-18 production	ISS
GO:0034067	Process	Protein localization to Golgi apparatus	IDA	21151871
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 20180847, 21151871
GO:0042803	Function	Protein homodimerization activity	IDA	21151871, 33876762
GO:0045087	Process	Innate immune response	IEA
GO:0045089	Process	Positive regulation of innate immune response	IEA
GO:0045089	Process	Positive regulation of innate immune response	ISS
GO:0046718	Process	Symbiont entry into host cell	IDA	9641677
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21151871
GO:0051289	Process	Protein homotetramerization	IDA	22461501
GO:0051604	Process	Protein maturation	IDA	31091448
GO:0051607	Process	Defense response to virus	IDA	26996307, 31091448
GO:0051715	Process	Cytolysis in another organism	IEA
GO:0051715	Process	Cytolysis in another organism	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071346	Process	Cellular response to type II interferon	IBA
GO:0071346	Process	Cellular response to type II interferon	IEA
GO:0071346	Process	Cellular response to type II interferon	IEP	17266443
GO:0098552	Component	Side of membrane	IEA
GO:0106139	Component	Symbiont cell surface	IEA
GO:0140639	Process	Positive regulation of pyroptotic inflammatory response	IEA
GO:0140639	Process	Positive regulation of pyroptotic inflammatory response	ISS
GO:0140678	Function	Molecular function inhibitor activity	IDA	31091448
GO:0140973	Process	Positive regulation of AIM2 inflammasome complex assembly	IEA
GO:0140973	Process	Positive regulation of AIM2 inflammasome complex assembly	ISS
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	IEA
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	ISS
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IDA	22461501

MIM	HGNC	e!Ensembl
611467	19895	ENSG00000154451

Q96PP8

Protein name

Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5)

Protein function

Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (P

PDB

7CKF , 7E59 , 7E5A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02263	GBP	18 → 280	Guanylate-binding protein, N-terminal domain	Domain
PF02841	GBP_C	282 → 574	Guanylate-binding protein, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in peripheral blood monocytes (at protein level). {ECO:0000269|PubMed:15175044}.

Sequence

MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL
LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL
RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA
HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN
AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER
EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV
KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL
TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQ
QKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL

Sequence length

586

Interactions

View interactions

	KEGG		Reactome
	NOD-like receptor signaling pathway		Interferon gamma signaling

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Neurodevelopmental disorder	Uncertain significance	rs540327216	RCV001262179

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anhedonia	Associate	30408130
Carcinoma Hepatocellular	Associate	33897701, 35637633, 37551111
Carcinoma Medullary	Associate	26965581
Celiac Disease	Associate	30097691
Chemical and Drug Induced Liver Injury	Associate	35637633
Colorectal Neoplasms	Associate	35213358
COVID 19	Associate	36507688
Inflammation	Stimulate	20180847
Inflammation	Associate	30408130, 36411825
Influenza Human	Stimulate	28376501
Intestinal Diseases	Associate	30097691
Lung Diseases	Associate	26025597
Lung Neoplasms	Associate	38136991
Lymphoma	Associate	20180847
Melanoma Cutaneous Malignant	Associate	32639949
Mouth Diseases	Stimulate	31600201
Myocardial Infarction	Associate	29381915
Neoplasms	Associate	15175044, 20180847, 32639949, 33897701
Ovarian Neoplasms	Associate	35163645
Pancreatic Neoplasms	Associate	32702921
Tuberculosis	Associate	26025597, 34193258, 36214761
Tuberculosis Meningeal	Stimulate	38169323
Tuberculosis Pulmonary	Associate	39922484

GBP5 (guanylate binding protein 5)