FCRL1 (Fc receptor like 1)

Gene

• Entrez ID: 115350
• Gene name: Fc receptor like 1
• Gene symbol: FCRL1
• Synonyms (NCBI Gene): CD307a, FCRH1, IFGP1, IRTA5
• Chromosome: 1
• Chromosome location: 1q23.1
• Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transm

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT994071	hsa-miR-1261	CLIP-seq
MIRT994072	hsa-miR-1269	CLIP-seq
MIRT994073	hsa-miR-1269b	CLIP-seq
MIRT994074	hsa-miR-1278	CLIP-seq
MIRT994075	hsa-miR-1285	CLIP-seq
MIRT994076	hsa-miR-1288	CLIP-seq
MIRT994077	hsa-miR-155	CLIP-seq
MIRT994078	hsa-miR-190	CLIP-seq
MIRT994079	hsa-miR-190b	CLIP-seq
MIRT994080	hsa-miR-1912	CLIP-seq
MIRT994081	hsa-miR-219-2-3p	CLIP-seq
MIRT994082	hsa-miR-2964a-3p	CLIP-seq
MIRT994083	hsa-miR-3130-5p	CLIP-seq
MIRT994084	hsa-miR-3187-5p	CLIP-seq
MIRT994085	hsa-miR-3201	CLIP-seq
MIRT994086	hsa-miR-3614-5p	CLIP-seq
MIRT994087	hsa-miR-3622b-5p	CLIP-seq
MIRT994088	hsa-miR-365	CLIP-seq
MIRT994089	hsa-miR-3662	CLIP-seq
MIRT994090	hsa-miR-3672	CLIP-seq
MIRT994091	hsa-miR-3926	CLIP-seq
MIRT994092	hsa-miR-3976	CLIP-seq
MIRT994093	hsa-miR-4252	CLIP-seq
MIRT994094	hsa-miR-432	CLIP-seq
MIRT994095	hsa-miR-4480	CLIP-seq
MIRT994096	hsa-miR-4482	CLIP-seq
MIRT994097	hsa-miR-4515	CLIP-seq
MIRT994098	hsa-miR-4529-3p	CLIP-seq
MIRT994099	hsa-miR-4680-3p	CLIP-seq
MIRT994100	hsa-miR-4740-5p	CLIP-seq
MIRT994101	hsa-miR-4786-5p	CLIP-seq
MIRT994102	hsa-miR-4791	CLIP-seq
MIRT994103	hsa-miR-522	CLIP-seq
MIRT994104	hsa-miR-548c-3p	CLIP-seq
MIRT994105	hsa-miR-548s	CLIP-seq
MIRT994106	hsa-miR-553	CLIP-seq
MIRT994107	hsa-miR-612	CLIP-seq
MIRT994108	hsa-miR-654-3p	CLIP-seq
MIRT994109	hsa-miR-661	CLIP-seq
MIRT994110	hsa-miR-769-5p	CLIP-seq
MIRT994111	hsa-miR-890	CLIP-seq
MIRT994077	hsa-miR-155	CLIP-seq
MIRT994081	hsa-miR-219-2-3p	CLIP-seq
MIRT994082	hsa-miR-2964a-3p	CLIP-seq
MIRT994088	hsa-miR-365	CLIP-seq
MIRT994093	hsa-miR-4252	CLIP-seq
MIRT994099	hsa-miR-4680-3p	CLIP-seq
MIRT1994785	hsa-miR-380	CLIP-seq
MIRT1994786	hsa-miR-3924	CLIP-seq
MIRT1994787	hsa-miR-4495	CLIP-seq
MIRT994101	hsa-miR-4786-5p	CLIP-seq
MIRT994104	hsa-miR-548c-3p	CLIP-seq
MIRT994110	hsa-miR-769-5p	CLIP-seq
MIRT2228932	hsa-miR-1208	CLIP-seq
MIRT994074	hsa-miR-1278	CLIP-seq
MIRT2228933	hsa-miR-1470	CLIP-seq
MIRT994077	hsa-miR-155	CLIP-seq
MIRT994081	hsa-miR-219-2-3p	CLIP-seq
MIRT994082	hsa-miR-2964a-3p	CLIP-seq
MIRT994088	hsa-miR-365	CLIP-seq
MIRT994093	hsa-miR-4252	CLIP-seq
MIRT2228934	hsa-miR-4420	CLIP-seq
MIRT2228935	hsa-miR-4667-3p	CLIP-seq
MIRT994099	hsa-miR-4680-3p	CLIP-seq
MIRT994103	hsa-miR-522	CLIP-seq
MIRT994104	hsa-miR-548c-3p	CLIP-seq
MIRT2680924	hsa-miR-2114	CLIP-seq
MIRT2680925	hsa-miR-214	CLIP-seq
MIRT2680926	hsa-miR-3619-5p	CLIP-seq
MIRT994087	hsa-miR-3622b-5p	CLIP-seq
MIRT2680927	hsa-miR-3929	CLIP-seq
MIRT2680928	hsa-miR-4291	CLIP-seq
MIRT2680929	hsa-miR-4419b	CLIP-seq
MIRT2680930	hsa-miR-4478	CLIP-seq
MIRT2680931	hsa-miR-455-5p	CLIP-seq
MIRT2680932	hsa-miR-4690-5p	CLIP-seq
MIRT2680933	hsa-miR-510	CLIP-seq
MIRT2680934	hsa-miR-512-5p	CLIP-seq
MIRT2680935	hsa-miR-550a	CLIP-seq
MIRT2680936	hsa-miR-761	CLIP-seq
MIRT2680937	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006955	Process	Immune response	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009986	Component	Cell surface	IDA	16849395
GO:0009986	Component	Cell surface	IEA
GO:0015026	Function	Coreceptor activity	IDA	15479727
GO:0016020	Component	Membrane	IEA
GO:0042113	Process	B cell activation	IDA	15479727

Other IDs

• MIM: 606508
• HGNC: 18509
• e!Ensembl: ENSG00000163534

Protein

• UniProt ID: Q96LA6
• Protein name: Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a)
• Protein function: Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses (PubMed:15479727). Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation (By similarity). A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13895	Ig_2	18 → 105	Immunoglobulin domain	Domain
  PF13927	Ig_3	113 → 187		Domain
  PF17736	Ig_C17orf99	217 → 296	C17orf99 Ig domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression
• Sequence:

  MLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRA
  LGPGWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPP
  GGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQ
  YYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILY
  WFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGA
  RSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSP
  TPGQLQPIYENVNVVSGDEVYSLAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKANI
  TDVDYEDAM

• Sequence length: 429