Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
114885
Gene name Gene Name - the full gene name approved by the HGNC.
Oxysterol binding protein like 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OSBPL11
Synonyms (NCBI Gene) Gene synonyms aliases
ORP-11, ORP11, OSBP12, TCCCIA00292
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like stero
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019404 hsa-miR-148b-3p Microarray 17612493
MIRT025790 hsa-miR-7-5p Microarray 17612493
MIRT040400 hsa-miR-615-3p CLASH 23622248
MIRT025790 hsa-miR-7-5p Luciferase reporter assay, Western blotting, qRT-PCR 35012554
MIRT1205988 hsa-miR-1185 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19615732, 20599956, 22906437
GO:0005654 Component Nucleoplasm IDA
GO:0005794 Component Golgi apparatus IDA
GO:0005829 Component Cytosol IBA 21873635
GO:0010890 Process Positive regulation of sequestering of triglyceride IMP 23028956
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606739 16397 ENSG00000144909
Protein
UniProt ID Q9BXB4
Protein name Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)
Protein function Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9
PDB 2D9X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 60 155 PH domain Domain
PF01237 Oxysterol_BP 372 738 Oxysterol-binding protein Family
Tissue specificity TISSUE SPECIFICITY: Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present
Sequence
Sequence length 747
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 31173207, 36918840
Cardiovascular Diseases Associate 19325544
Diabetes Mellitus Associate 19325544
Hyperglycemia Associate 19325544
Mandibulofacial Dysostosis Associate 28051070
Metabolic Syndrome Stimulate 19325544
Metabolic Syndrome Associate 19325544
Neoplasms Associate 36918840
Neurodegenerative Diseases Associate 28051070
Obesity Associate 19325544