Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	114880
Gene name	Oxysterol binding protein like 6
Gene symbol	OSBPL6
Synonyms (NCBI Gene)	ORP6
Chromosome	2
Chromosome location	2q31.2
Summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcrip

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024344	hsa-miR-215-5p	Microarray	19074876
MIRT024344	hsa-miR-215-5p	Microarray	19074876
MIRT026268	hsa-miR-192-5p	Microarray	19074876
MIRT732159	hsa-miR-33a-5p	ImmunoprecipitaionLuciferase reporter assayqRT-PCR	26941018
MIRT732159	hsa-miR-33a-5p	ImmunoprecipitaionLuciferase reporter assayqRT-PCR	26941018
MIRT732160	hsa-miR-27b-3p	ImmunoprecipitaionLuciferase reporter assayqRT-PCR	26941018
MIRT732160	hsa-miR-27b-3p	ImmunoprecipitaionLuciferase reporter assayqRT-PCR	26941018
MIRT732160	hsa-miR-27b-3p	ImmunoprecipitaionLuciferase reporter assayqRT-PCR	26941018
MIRT1206298	hsa-miR-1246	CLIP-seq
MIRT1206299	hsa-miR-200b	CLIP-seq
MIRT1206300	hsa-miR-200c	CLIP-seq
MIRT1206301	hsa-miR-216b	CLIP-seq
MIRT1206302	hsa-miR-298	CLIP-seq
MIRT1206303	hsa-miR-3127-5p	CLIP-seq
MIRT1206304	hsa-miR-3145-3p	CLIP-seq
MIRT1206305	hsa-miR-3150b-3p	CLIP-seq
MIRT1206306	hsa-miR-3672	CLIP-seq
MIRT1206307	hsa-miR-3921	CLIP-seq
MIRT1206308	hsa-miR-4270	CLIP-seq
MIRT1206309	hsa-miR-429	CLIP-seq
MIRT1206310	hsa-miR-4441	CLIP-seq
MIRT1206311	hsa-miR-4496	CLIP-seq
MIRT1206312	hsa-miR-4649-3p	CLIP-seq
MIRT1206313	hsa-miR-4653-5p	CLIP-seq
MIRT1206314	hsa-miR-4689	CLIP-seq
MIRT1206315	hsa-miR-4784	CLIP-seq
MIRT1206316	hsa-miR-603	CLIP-seq
MIRT1206317	hsa-miR-302a	CLIP-seq
MIRT1206318	hsa-miR-302b	CLIP-seq
MIRT1206319	hsa-miR-302c	CLIP-seq
MIRT1206320	hsa-miR-302d	CLIP-seq
MIRT1206321	hsa-miR-302e	CLIP-seq
MIRT1206303	hsa-miR-3127-5p	CLIP-seq
MIRT1206322	hsa-miR-3140-3p	CLIP-seq
MIRT1206306	hsa-miR-3672	CLIP-seq
MIRT1206323	hsa-miR-372	CLIP-seq
MIRT1206324	hsa-miR-373	CLIP-seq
MIRT1206308	hsa-miR-4270	CLIP-seq
MIRT1206310	hsa-miR-4441	CLIP-seq
MIRT1206325	hsa-miR-520a-3p	CLIP-seq
MIRT1206326	hsa-miR-520b	CLIP-seq
MIRT1206327	hsa-miR-520c-3p	CLIP-seq
MIRT1206328	hsa-miR-520d-3p	CLIP-seq
MIRT1206329	hsa-miR-520e	CLIP-seq
MIRT1206330	hsa-miR-628-3p	CLIP-seq
MIRT1206331	hsa-miR-1231	CLIP-seq
MIRT1206332	hsa-miR-1324	CLIP-seq
MIRT1206333	hsa-miR-141	CLIP-seq
MIRT1206334	hsa-miR-200a	CLIP-seq
MIRT1206299	hsa-miR-200b	CLIP-seq
MIRT1206300	hsa-miR-200c	CLIP-seq
MIRT1206335	hsa-miR-2115	CLIP-seq
MIRT1206336	hsa-miR-2467-3p	CLIP-seq
MIRT1206337	hsa-miR-3120-5p	CLIP-seq
MIRT1206338	hsa-miR-3180-5p	CLIP-seq
MIRT1206339	hsa-miR-3194-3p	CLIP-seq
MIRT1206340	hsa-miR-320a	CLIP-seq
MIRT1206341	hsa-miR-320b	CLIP-seq
MIRT1206342	hsa-miR-320c	CLIP-seq
MIRT1206343	hsa-miR-320d	CLIP-seq
MIRT1206344	hsa-miR-331-3p	CLIP-seq
MIRT1206345	hsa-miR-3650	CLIP-seq
MIRT1206346	hsa-miR-3678-3p	CLIP-seq
MIRT1206347	hsa-miR-3944-5p	CLIP-seq
MIRT1206309	hsa-miR-429	CLIP-seq
MIRT1206348	hsa-miR-4422	CLIP-seq
MIRT1206349	hsa-miR-4429	CLIP-seq
MIRT1206350	hsa-miR-4490	CLIP-seq
MIRT1206351	hsa-miR-4502	CLIP-seq
MIRT1206352	hsa-miR-4693-5p	CLIP-seq
MIRT1206353	hsa-miR-4774-5p	CLIP-seq
MIRT1206354	hsa-miR-501-5p	CLIP-seq
MIRT1206355	hsa-miR-516a-3p	CLIP-seq
MIRT1206356	hsa-miR-520a-5p	CLIP-seq
MIRT1206357	hsa-miR-525-5p	CLIP-seq
MIRT1206330	hsa-miR-628-3p	CLIP-seq
MIRT1206358	hsa-miR-767-3p	CLIP-seq
MIRT1922893	hsa-miR-1290	CLIP-seq
MIRT1922894	hsa-miR-3167	CLIP-seq
MIRT1922895	hsa-miR-3691-5p	CLIP-seq
MIRT1922896	hsa-miR-4752	CLIP-seq
MIRT1922897	hsa-miR-876-5p	CLIP-seq
MIRT1922893	hsa-miR-1290	CLIP-seq
MIRT2059398	hsa-miR-1298	CLIP-seq
MIRT1206302	hsa-miR-298	CLIP-seq
MIRT2059399	hsa-miR-3124-3p	CLIP-seq
MIRT1922894	hsa-miR-3167	CLIP-seq
MIRT2059400	hsa-miR-4438	CLIP-seq
MIRT2059401	hsa-miR-4494	CLIP-seq
MIRT2059402	hsa-miR-4729	CLIP-seq
MIRT2059403	hsa-miR-499a-5p	CLIP-seq
MIRT2059404	hsa-miR-5095	CLIP-seq
MIRT2059405	hsa-miR-520d-5p	CLIP-seq
MIRT2059406	hsa-miR-524-5p	CLIP-seq
MIRT2059407	hsa-miR-582-3p	CLIP-seq
MIRT2059408	hsa-miR-587	CLIP-seq
MIRT2059409	hsa-miR-664	CLIP-seq
MIRT1922897	hsa-miR-876-5p	CLIP-seq
MIRT2287762	hsa-miR-4781-3p	CLIP-seq
MIRT2287763	hsa-miR-4803	CLIP-seq
MIRT1922893	hsa-miR-1290	CLIP-seq
MIRT1922894	hsa-miR-3167	CLIP-seq
MIRT1922897	hsa-miR-876-5p	CLIP-seq
MIRT2585857	hsa-miR-1266	CLIP-seq
MIRT1206302	hsa-miR-298	CLIP-seq
MIRT2585858	hsa-miR-3133	CLIP-seq
MIRT2585859	hsa-miR-3664-3p	CLIP-seq
MIRT2585860	hsa-miR-4518	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22190034, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	26941018
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	14593528
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14593528
GO:0005886	Component	Plasma membrane	IEA
GO:0006699	Process	Bile acid biosynthetic process	IEA
GO:0006699	Process	Bile acid biosynthetic process	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0015485	Function	Cholesterol binding	IBA
GO:0015918	Process	Sterol transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0031901	Component	Early endosome membrane	IDA	26941018
GO:0031965	Component	Nuclear membrane	IBA
GO:0031965	Component	Nuclear membrane	IDA	14593528
GO:0032374	Process	Regulation of cholesterol transport	IMP	26941018
GO:0097038	Component	Perinuclear endoplasmic reticulum	IBA
GO:0097038	Component	Perinuclear endoplasmic reticulum	IDA	14593528
GO:0097038	Component	Perinuclear endoplasmic reticulum	IEA
GO:0120015	Function	Sterol transfer activity	IEA
GO:0120015	Function	Sterol transfer activity	TAS

MIM	HGNC	e!Ensembl
606734	16388	ENSG00000079156

Q9BZF3

Protein name

Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)

Protein function

Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15409	PH_8	91 → 180	Pleckstrin homology domain	Domain
PF01237	Oxysterol_BP	570 → 918	Oxysterol-binding protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).

Sequence

MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEP
VPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSK
APLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHR
LYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPAT
CTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQAN
CVDISKKDKRVTRRWRTKSVSKDTKIQLQVPFSATMSPVRLHSSNPNLCADIEFQTPPSH
LTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQM
ARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQV
ANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQ
ILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQ
HLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIR
EDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKY
GDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQG
VVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDP
VLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKK
VIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW

Sequence length

934

Interactions

View interactions

	Reactome
			Synthesis of bile acids and bile salts

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	36918840	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	36918840	★★★★★ ★☆☆☆☆ Found in Text Mining only

OSBPL6 (oxysterol binding protein like 6)