Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	114879
Gene name Gene Name - the full gene name approved by the HGNC.	Oxysterol binding protein like 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	OSBPL5
Synonyms (NCBI Gene) Gene synonyms aliases	OBPH1, ORP5
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain a

Show/Hide all(123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT526466	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT526465	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT526464	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT526463	hsa-miR-1539	PAR-CLIP	22012620
MIRT526462	hsa-miR-744-5p	PAR-CLIP	22012620
MIRT526461	hsa-miR-4640-5p	PAR-CLIP	22012620
MIRT526460	hsa-miR-4726-5p	PAR-CLIP	22012620
MIRT526459	hsa-miR-6762-5p	PAR-CLIP	22012620
MIRT526458	hsa-miR-6845-5p	PAR-CLIP	22012620
MIRT526466	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT526465	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT526464	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT526463	hsa-miR-1539	PAR-CLIP	22012620
MIRT526462	hsa-miR-744-5p	PAR-CLIP	22012620
MIRT526461	hsa-miR-4640-5p	PAR-CLIP	22012620
MIRT526460	hsa-miR-4726-5p	PAR-CLIP	22012620
MIRT526459	hsa-miR-6762-5p	PAR-CLIP	22012620
MIRT526458	hsa-miR-6845-5p	PAR-CLIP	22012620
MIRT1206251	hsa-miR-1184	CLIP-seq
MIRT1206252	hsa-miR-1224-3p	CLIP-seq
MIRT1206253	hsa-miR-128	CLIP-seq
MIRT1206254	hsa-miR-1301	CLIP-seq
MIRT1206255	hsa-miR-25	CLIP-seq
MIRT1206256	hsa-miR-27a	CLIP-seq
MIRT1206257	hsa-miR-27b	CLIP-seq
MIRT1206258	hsa-miR-31	CLIP-seq
MIRT1206259	hsa-miR-32	CLIP-seq
MIRT1206260	hsa-miR-363	CLIP-seq
MIRT1206261	hsa-miR-367	CLIP-seq
MIRT1206262	hsa-miR-3690	CLIP-seq
MIRT1206263	hsa-miR-378	CLIP-seq
MIRT1206264	hsa-miR-378b	CLIP-seq
MIRT1206265	hsa-miR-378c	CLIP-seq
MIRT1206266	hsa-miR-378d	CLIP-seq
MIRT1206267	hsa-miR-378e	CLIP-seq
MIRT1206268	hsa-miR-378f	CLIP-seq
MIRT1206269	hsa-miR-378h	CLIP-seq
MIRT1206270	hsa-miR-378i	CLIP-seq
MIRT1206271	hsa-miR-3929	CLIP-seq
MIRT1206272	hsa-miR-422a	CLIP-seq
MIRT1206273	hsa-miR-4307	CLIP-seq
MIRT1206274	hsa-miR-4418	CLIP-seq
MIRT1206275	hsa-miR-4419b	CLIP-seq
MIRT1206276	hsa-miR-4426	CLIP-seq
MIRT1206277	hsa-miR-4433	CLIP-seq
MIRT1206278	hsa-miR-4435	CLIP-seq
MIRT1206279	hsa-miR-4478	CLIP-seq
MIRT1206280	hsa-miR-4493	CLIP-seq
MIRT1206281	hsa-miR-4647	CLIP-seq
MIRT1206282	hsa-miR-4660	CLIP-seq
MIRT1206283	hsa-miR-4662b	CLIP-seq
MIRT1206284	hsa-miR-4687-3p	CLIP-seq
MIRT1206285	hsa-miR-4690-3p	CLIP-seq
MIRT1206286	hsa-miR-5047	CLIP-seq
MIRT1206287	hsa-miR-509-3-5p	CLIP-seq
MIRT1206288	hsa-miR-509-5p	CLIP-seq
MIRT1206289	hsa-miR-548al	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT1206291	hsa-miR-92a	CLIP-seq
MIRT1206292	hsa-miR-92b	CLIP-seq
MIRT1206258	hsa-miR-31	CLIP-seq
MIRT1206276	hsa-miR-4426	CLIP-seq
MIRT1206277	hsa-miR-4433	CLIP-seq
MIRT1206278	hsa-miR-4435	CLIP-seq
MIRT1206293	hsa-miR-4466	CLIP-seq
MIRT1206281	hsa-miR-4647	CLIP-seq
MIRT1206283	hsa-miR-4662b	CLIP-seq
MIRT1206294	hsa-miR-4706	CLIP-seq
MIRT1206295	hsa-miR-4749-5p	CLIP-seq
MIRT1206289	hsa-miR-548al	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT1206296	hsa-miR-675	CLIP-seq
MIRT1206297	hsa-miR-744	CLIP-seq
MIRT2287748	hsa-miR-106a	CLIP-seq
MIRT2287749	hsa-miR-106b	CLIP-seq
MIRT2287750	hsa-miR-17	CLIP-seq
MIRT2287751	hsa-miR-20a	CLIP-seq
MIRT2287752	hsa-miR-20b	CLIP-seq
MIRT2287753	hsa-miR-3183	CLIP-seq
MIRT2287754	hsa-miR-3609	CLIP-seq
MIRT2287755	hsa-miR-4723-3p	CLIP-seq
MIRT2287756	hsa-miR-4728-5p	CLIP-seq
MIRT2287757	hsa-miR-4757-5p	CLIP-seq
MIRT2287758	hsa-miR-4796-3p	CLIP-seq
MIRT2287759	hsa-miR-519d	CLIP-seq
MIRT2287760	hsa-miR-548ah	CLIP-seq
MIRT2287761	hsa-miR-93	CLIP-seq
MIRT2465776	hsa-miR-1266	CLIP-seq
MIRT2465777	hsa-miR-1913	CLIP-seq
MIRT2465778	hsa-miR-28-5p	CLIP-seq
MIRT2465779	hsa-miR-3127-5p	CLIP-seq
MIRT2465780	hsa-miR-3139	CLIP-seq
MIRT2465781	hsa-miR-3194-3p	CLIP-seq
MIRT2465782	hsa-miR-324-3p	CLIP-seq
MIRT2465783	hsa-miR-3918	CLIP-seq
MIRT2465784	hsa-miR-4290	CLIP-seq
MIRT2465785	hsa-miR-4518	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT2465786	hsa-miR-708	CLIP-seq
MIRT2465776	hsa-miR-1266	CLIP-seq
MIRT2465777	hsa-miR-1913	CLIP-seq
MIRT2465778	hsa-miR-28-5p	CLIP-seq
MIRT2465779	hsa-miR-3127-5p	CLIP-seq
MIRT2465780	hsa-miR-3139	CLIP-seq
MIRT2465781	hsa-miR-3194-3p	CLIP-seq
MIRT2465782	hsa-miR-324-3p	CLIP-seq
MIRT2465783	hsa-miR-3918	CLIP-seq
MIRT2465784	hsa-miR-4290	CLIP-seq
MIRT2465785	hsa-miR-4518	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT2465786	hsa-miR-708	CLIP-seq
MIRT2465776	hsa-miR-1266	CLIP-seq
MIRT2465777	hsa-miR-1913	CLIP-seq
MIRT2465778	hsa-miR-28-5p	CLIP-seq
MIRT2465779	hsa-miR-3127-5p	CLIP-seq
MIRT2465780	hsa-miR-3139	CLIP-seq
MIRT2465781	hsa-miR-3194-3p	CLIP-seq
MIRT2465782	hsa-miR-324-3p	CLIP-seq
MIRT2465783	hsa-miR-3918	CLIP-seq
MIRT2465784	hsa-miR-4290	CLIP-seq
MIRT2465785	hsa-miR-4518	CLIP-seq
MIRT1206290	hsa-miR-665	CLIP-seq
MIRT2465786	hsa-miR-708	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IDA	23934110, 26206935
GO:0005548	Function	Phospholipid transporter activity	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	NAS	10588946
GO:0005829	Component	Cytosol	TAS
GO:0006893	Process	Golgi to plasma membrane transport	NAS	10588946
GO:0008142	Function	Oxysterol binding	NAS	10588946
GO:0008203	Process	Cholesterol metabolic process	NAS	10588946
GO:0015248	Function	Sterol transporter activity	IBA	21873635
GO:0015485	Function	Cholesterol binding	IDA	17428193
GO:0015914	Process	Phospholipid transport	IDA	26206935
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0030301	Process	Cholesterol transport	NAS	10588946
GO:0032934	Function	Sterol binding	IBA	21873635
GO:0036150	Process	Phosphatidylserine acyl-chain remodeling	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0070273	Function	Phosphatidylinositol-4-phosphate binding	IDA	26206935
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0140268	Component	Endoplasmic reticulum-plasma membrane contact site	IDA	26206935, 30220461
GO:0140343	Function	Phosphatidylserine transfer activity	IDA	26206935

MIM	HGNC	e!Ensembl
606733	16392	ENSG00000021762

Protein

UniProt ID

Q9H0X9

Protein name

Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)

Protein function

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma m

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	126 → 243	PH domain	Domain
PF01237	Oxysterol_BP	371 → 716	Oxysterol-binding protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12504849, ECO:0000269|PubMed:21220512}.

Sequence

MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
LTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERP
SKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALEL
ALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAF
SDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQV
ETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEE
DAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHP
PVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCK
GILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLS
GHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISK
GDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKD
IAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGS
TPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAML
SSTARAAQAPTPGLLQSPRSWFLLCVFLACQLFINHILK

Sequence length

879

Interactions

View interactions

	KEGG		Reactome
	Cholesterol metabolism		Acyl chain remodelling of PS

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.	GWAS, CBGDA

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	36918840
Carcinoma Non Small Cell Lung	Associate	35000595
Disease	Associate	25052311
Neoplasms	Associate	29358326, 36918840
Ovarian Neoplasms	Associate	36366750
Pancreatic Neoplasms	Associate	20128820
Prostatic Neoplasms	Associate	32048780
Renal Insufficiency	Associate	25504873
Skin Diseases	Associate	30779748
Triploidy	Associate	25504873

OSBPL5 (oxysterol binding protein like 5)