Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	114836
Gene name	SLAM family member 6
Gene symbol	SLAMF6
Synonyms (NCBI Gene)	CD352KALIKALIbLy108NTB-ANTBASF2000
Chromosome	1
Chromosome location	1q23.2-q23.3
Summary	The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and

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miRTarBase ID	miRNA	Experiments
MIRT1351478	hsa-let-7a	CLIP-seq
MIRT1351479	hsa-let-7b	CLIP-seq
MIRT1351480	hsa-let-7c	CLIP-seq
MIRT1351481	hsa-let-7d	CLIP-seq
MIRT1351482	hsa-let-7e	CLIP-seq
MIRT1351483	hsa-let-7f	CLIP-seq
MIRT1351484	hsa-let-7g	CLIP-seq
MIRT1351485	hsa-let-7i	CLIP-seq
MIRT1351486	hsa-miR-202	CLIP-seq
MIRT1351487	hsa-miR-3927	CLIP-seq
MIRT1351488	hsa-miR-4303	CLIP-seq
MIRT1351489	hsa-miR-4451	CLIP-seq
MIRT1351490	hsa-miR-4458	CLIP-seq
MIRT1351491	hsa-miR-4500	CLIP-seq
MIRT1351492	hsa-miR-4649-3p	CLIP-seq
MIRT1351493	hsa-miR-4762-3p	CLIP-seq
MIRT1351494	hsa-miR-98	CLIP-seq
MIRT2104172	hsa-miR-1236	CLIP-seq
MIRT2104173	hsa-miR-1343	CLIP-seq
MIRT2104174	hsa-miR-1976	CLIP-seq
MIRT2104175	hsa-miR-24	CLIP-seq
MIRT2104176	hsa-miR-371-5p	CLIP-seq
MIRT2104177	hsa-miR-4279	CLIP-seq
MIRT2104178	hsa-miR-4284	CLIP-seq
MIRT2104179	hsa-miR-4722-3p	CLIP-seq
MIRT2104180	hsa-miR-498	CLIP-seq
MIRT2104173	hsa-miR-1343	CLIP-seq
MIRT2328289	hsa-miR-1915	CLIP-seq
MIRT2104174	hsa-miR-1976	CLIP-seq
MIRT2328290	hsa-miR-2861	CLIP-seq
MIRT2328291	hsa-miR-3187-3p	CLIP-seq
MIRT2328292	hsa-miR-3545-3p	CLIP-seq
MIRT2328293	hsa-miR-3663-5p	CLIP-seq
MIRT2328294	hsa-miR-4264	CLIP-seq
MIRT2104177	hsa-miR-4279	CLIP-seq
MIRT2328295	hsa-miR-4435	CLIP-seq
MIRT2328296	hsa-miR-4512	CLIP-seq
MIRT2328297	hsa-miR-4635	CLIP-seq
MIRT2328298	hsa-miR-4680-5p	CLIP-seq
MIRT2328299	hsa-miR-4701-5p	CLIP-seq
MIRT2328300	hsa-miR-4715-5p	CLIP-seq
MIRT2104179	hsa-miR-4722-3p	CLIP-seq
MIRT2328301	hsa-miR-4726-3p	CLIP-seq
MIRT2328302	hsa-miR-4755-3p	CLIP-seq
MIRT2328303	hsa-miR-4768-3p	CLIP-seq
MIRT2104180	hsa-miR-498	CLIP-seq
MIRT2328304	hsa-miR-548s	CLIP-seq
MIRT2328305	hsa-miR-588	CLIP-seq
MIRT2328306	hsa-miR-622	CLIP-seq
MIRT2328307	hsa-miR-665	CLIP-seq
MIRT2104173	hsa-miR-1343	CLIP-seq
MIRT2104174	hsa-miR-1976	CLIP-seq
MIRT2328294	hsa-miR-4264	CLIP-seq
MIRT2104177	hsa-miR-4279	CLIP-seq
MIRT2104179	hsa-miR-4722-3p	CLIP-seq
MIRT2104180	hsa-miR-498	CLIP-seq
MIRT2623076	hsa-miR-129-5p	CLIP-seq
MIRT2104173	hsa-miR-1343	CLIP-seq
MIRT2104174	hsa-miR-1976	CLIP-seq
MIRT2623077	hsa-miR-3149	CLIP-seq
MIRT2328294	hsa-miR-4264	CLIP-seq
MIRT2104177	hsa-miR-4279	CLIP-seq
MIRT2104179	hsa-miR-4722-3p	CLIP-seq
MIRT2623078	hsa-miR-4735-5p	CLIP-seq
MIRT2623079	hsa-miR-4775	CLIP-seq
MIRT2623080	hsa-miR-4794	CLIP-seq
MIRT2104180	hsa-miR-498	CLIP-seq
MIRT2623081	hsa-miR-590-3p	CLIP-seq
MIRT2328306	hsa-miR-622	CLIP-seq
MIRT2623076	hsa-miR-129-5p	CLIP-seq
MIRT2104173	hsa-miR-1343	CLIP-seq
MIRT2104174	hsa-miR-1976	CLIP-seq
MIRT2623077	hsa-miR-3149	CLIP-seq
MIRT2328294	hsa-miR-4264	CLIP-seq
MIRT2104177	hsa-miR-4279	CLIP-seq
MIRT2104179	hsa-miR-4722-3p	CLIP-seq
MIRT2623078	hsa-miR-4735-5p	CLIP-seq
MIRT2623079	hsa-miR-4775	CLIP-seq
MIRT2623080	hsa-miR-4794	CLIP-seq
MIRT2104180	hsa-miR-498	CLIP-seq
MIRT2623081	hsa-miR-590-3p	CLIP-seq
MIRT2328306	hsa-miR-622	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	11489943, 16920955, 22912825, 23346089, 24688028, 32296183
GO:0005886	Component	Plasma membrane	IDA	22184727
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0032729	Process	Positive regulation of type II interferon production	IMP	16920955
GO:0032740	Process	Positive regulation of interleukin-17 production	IDA	22184727
GO:0042110	Process	T cell activation	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0045954	Process	Positive regulation of natural killer cell mediated cytotoxicity	IDA	16920955
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0072540	Process	T-helper 17 cell lineage commitment	IDA	22184727

MIM	HGNC	e!Ensembl
606446	21392	ENSG00000162739

Q96DU3

Protein name

SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)

Protein function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and

PDB

2IF7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	26 → 127	Immunoglobulin V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes (PubMed:11489943). Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients (PubMed:22184727). {ECO:0000269|PubMed:1

Sequence

MLWLFQSLLFVFCFGPGNVVSQSSLTPLMVNGILGESVTLPLEFPAGEKVNFITWLFNET
SLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLS
SYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADDNVSFRWEALGNTLSSQPNLT
VSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDTKMILFMVSGICIVFGF
IILLLLVLRKRRDSLSLSTQRTQGPAESARNLEYVSVSPTNNTVYASVTHSNRETEIWTP
RENDTITIYSTINHSKESKPTFSRATALDNVV

Sequence length

332

Interactions

View interactions

	Reactome
			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SLAMF6 (SLAM family member 6)