SLC22A9 (solute carrier family 22 member 9)

Gene

• Entrez ID: 114571
• Gene name: Solute carrier family 22 member 9
• Gene symbol: SLC22A9
• Synonyms (NCBI Gene): HOAT4, OAT4, OAT7, UST3H, ust3
• Chromosome: 11
• Chromosome location: 11q12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT622258	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT622257	hsa-miR-4277	HITS-CLIP	23824327
MIRT622256	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT622255	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT622254	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT622253	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT622252	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT622251	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT622250	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT622249	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT622248	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT622258	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT622257	hsa-miR-4277	HITS-CLIP	23824327
MIRT622256	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT622255	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT622254	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT622253	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT622252	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT622251	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT622250	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT622249	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT622248	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT2104950	hsa-miR-1	CLIP-seq
MIRT2104951	hsa-miR-1226	CLIP-seq
MIRT2104952	hsa-miR-1297	CLIP-seq
MIRT2104953	hsa-miR-1343	CLIP-seq
MIRT2104954	hsa-miR-150	CLIP-seq
MIRT2104955	hsa-miR-18a	CLIP-seq
MIRT2104956	hsa-miR-18b	CLIP-seq
MIRT2104957	hsa-miR-1913	CLIP-seq
MIRT2104958	hsa-miR-1976	CLIP-seq
MIRT2104959	hsa-miR-206	CLIP-seq
MIRT2104960	hsa-miR-26a	CLIP-seq
MIRT2104961	hsa-miR-26b	CLIP-seq
MIRT2104962	hsa-miR-3136-3p	CLIP-seq
MIRT2104963	hsa-miR-324-3p	CLIP-seq
MIRT2104964	hsa-miR-3652	CLIP-seq
MIRT2104965	hsa-miR-3673	CLIP-seq
MIRT2104966	hsa-miR-3677-5p	CLIP-seq
MIRT2104967	hsa-miR-3692	CLIP-seq
MIRT2104968	hsa-miR-4279	CLIP-seq
MIRT2104969	hsa-miR-4430	CLIP-seq
MIRT2104970	hsa-miR-4438	CLIP-seq
MIRT2104971	hsa-miR-4465	CLIP-seq
MIRT2104972	hsa-miR-4707-3p	CLIP-seq
MIRT2104973	hsa-miR-4722-3p	CLIP-seq
MIRT2104974	hsa-miR-4731-5p	CLIP-seq
MIRT2104975	hsa-miR-4733-3p	CLIP-seq
MIRT2104976	hsa-miR-4735-3p	CLIP-seq
MIRT2104977	hsa-miR-4761-5p	CLIP-seq
MIRT2104978	hsa-miR-5095	CLIP-seq
MIRT2104979	hsa-miR-562	CLIP-seq
MIRT2104980	hsa-miR-613	CLIP-seq
MIRT2104981	hsa-miR-663b	CLIP-seq
MIRT2104950	hsa-miR-1	CLIP-seq
MIRT2104951	hsa-miR-1226	CLIP-seq
MIRT2104954	hsa-miR-150	CLIP-seq
MIRT2104955	hsa-miR-18a	CLIP-seq
MIRT2104956	hsa-miR-18b	CLIP-seq
MIRT2104957	hsa-miR-1913	CLIP-seq
MIRT2104958	hsa-miR-1976	CLIP-seq
MIRT2104959	hsa-miR-206	CLIP-seq
MIRT2104962	hsa-miR-3136-3p	CLIP-seq
MIRT2104963	hsa-miR-324-3p	CLIP-seq
MIRT2104964	hsa-miR-3652	CLIP-seq
MIRT2104965	hsa-miR-3673	CLIP-seq
MIRT2104966	hsa-miR-3677-5p	CLIP-seq
MIRT2104967	hsa-miR-3692	CLIP-seq
MIRT2104968	hsa-miR-4279	CLIP-seq
MIRT2104969	hsa-miR-4430	CLIP-seq
MIRT2104970	hsa-miR-4438	CLIP-seq
MIRT2104972	hsa-miR-4707-3p	CLIP-seq
MIRT2104973	hsa-miR-4722-3p	CLIP-seq
MIRT2104974	hsa-miR-4731-5p	CLIP-seq
MIRT2104975	hsa-miR-4733-3p	CLIP-seq
MIRT2104976	hsa-miR-4735-3p	CLIP-seq
MIRT2104977	hsa-miR-4761-5p	CLIP-seq
MIRT2104978	hsa-miR-5095	CLIP-seq
MIRT2104980	hsa-miR-613	CLIP-seq
MIRT2104981	hsa-miR-663b	CLIP-seq
MIRT2104950	hsa-miR-1	CLIP-seq
MIRT2104951	hsa-miR-1226	CLIP-seq
MIRT2104959	hsa-miR-206	CLIP-seq
MIRT2104962	hsa-miR-3136-3p	CLIP-seq
MIRT2104964	hsa-miR-3652	CLIP-seq
MIRT2104965	hsa-miR-3673	CLIP-seq
MIRT2104966	hsa-miR-3677-5p	CLIP-seq
MIRT2104969	hsa-miR-4430	CLIP-seq
MIRT2104975	hsa-miR-4733-3p	CLIP-seq
MIRT2104980	hsa-miR-613	CLIP-seq
MIRT2104981	hsa-miR-663b	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HNF1A	Activation	20829431

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0009914	Process	Hormone transport	IDA	17393504
GO:0015301	Function	Anion:anion antiporter activity	IDA	17393504
GO:0015347	Function	Sodium-independent organic anion transmembrane transporter activity	IDA	17393504
GO:0015636	Function	Short-chain fatty acid transmembrane transporter activity	IDA	17393504
GO:0015711	Process	Organic anion transport	IBA	21873635
GO:0015912	Process	Short-chain fatty acid transport	IEA
GO:0015913	Process	Short-chain fatty acid import	IDA	17393504
GO:0016021	Component	Integral component of membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	17393504
GO:0043252	Process	Sodium-independent organic anion transport	IDA	17393504
GO:0098656	Process	Anion transmembrane transport	IEA

Other IDs

• MIM: 607579
• HGNC: 16261
• e!Ensembl: ENSG00000149742

Protein

• UniProt ID: Q8IVM8
• Protein name: Organic anion transporter 7 (OAT7) (Organic anion/short-chain fatty acid exchanger) (Solute carrier family 22 member 9)
• Protein function: Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) (PubMed:17393504, PubMed:26239079, Pub
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07690	MFS_1	116 → 485	Major Facilitator Superfamily	Family

• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in liver (also at protein level). {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:17393504, ECO:0000269|PubMed:26239079}.
• Sequence:

  MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS
  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW
  VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY
  LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP
  SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR
  KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA
  NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC
  LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA
  GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE
  PKQEDPRVEVTQF

• Sequence length: 553

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	34599518
Gout	Associate	35264217
Neoplasms	Associate	35510337