Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	113878
Gene name	Deltex E3 ubiquitin ligase 2
Gene symbol	DTX2
Synonyms (NCBI Gene)	RNF58
Chromosome	7
Chromosome location	7q11.23
Summary	DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050508	hsa-miR-20a-5p	CLASH	23622248
MIRT486947	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT486946	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT486944	hsa-miR-940	PAR-CLIP	23592263
MIRT486945	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT486943	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT486942	hsa-miR-4514	PAR-CLIP	23592263
MIRT486941	hsa-miR-4692	PAR-CLIP	23592263
MIRT486940	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT486938	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT486939	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT486937	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT486936	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT486935	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT486934	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT486933	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT486932	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT486931	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT486929	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT486930	hsa-miR-5698	PAR-CLIP	23592263
MIRT486928	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT486927	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT486947	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT486946	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT486944	hsa-miR-940	PAR-CLIP	23592263
MIRT486945	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT486943	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT486942	hsa-miR-4514	PAR-CLIP	23592263
MIRT486941	hsa-miR-4692	PAR-CLIP	23592263
MIRT486940	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT486938	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT486939	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT486937	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT486936	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT486935	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT486934	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT486933	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT486932	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT486931	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT486929	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT486930	hsa-miR-5698	PAR-CLIP	23592263
MIRT486928	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT486927	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT946975	hsa-let-7a	CLIP-seq
MIRT946976	hsa-let-7b	CLIP-seq
MIRT946977	hsa-let-7c	CLIP-seq
MIRT946978	hsa-let-7d	CLIP-seq
MIRT946979	hsa-let-7e	CLIP-seq
MIRT946980	hsa-let-7f	CLIP-seq
MIRT946981	hsa-let-7g	CLIP-seq
MIRT946982	hsa-let-7i	CLIP-seq
MIRT946983	hsa-miR-125a-3p	CLIP-seq
MIRT946984	hsa-miR-137	CLIP-seq
MIRT946985	hsa-miR-1827	CLIP-seq
MIRT946986	hsa-miR-185	CLIP-seq
MIRT946987	hsa-miR-1909	CLIP-seq
MIRT946988	hsa-miR-202	CLIP-seq
MIRT946989	hsa-miR-25	CLIP-seq
MIRT946990	hsa-miR-3150b-3p	CLIP-seq
MIRT946991	hsa-miR-3151	CLIP-seq
MIRT946992	hsa-miR-32	CLIP-seq
MIRT946993	hsa-miR-363	CLIP-seq
MIRT946994	hsa-miR-367	CLIP-seq
MIRT946995	hsa-miR-3934	CLIP-seq
MIRT946996	hsa-miR-4306	CLIP-seq
MIRT946997	hsa-miR-4458	CLIP-seq
MIRT946998	hsa-miR-4500	CLIP-seq
MIRT946999	hsa-miR-4644	CLIP-seq
MIRT947000	hsa-miR-4784	CLIP-seq
MIRT947001	hsa-miR-486-3p	CLIP-seq
MIRT947002	hsa-miR-518a-5p	CLIP-seq
MIRT947003	hsa-miR-527	CLIP-seq
MIRT947004	hsa-miR-764	CLIP-seq
MIRT947005	hsa-miR-765	CLIP-seq
MIRT947006	hsa-miR-92a	CLIP-seq
MIRT947007	hsa-miR-92b	CLIP-seq
MIRT947008	hsa-miR-939	CLIP-seq
MIRT947009	hsa-miR-98	CLIP-seq
MIRT1980440	hsa-miR-3663-3p	CLIP-seq
MIRT1980441	hsa-miR-3943	CLIP-seq
MIRT1980441	hsa-miR-3943	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 19549727, 21516116, 24722188, 25416956, 25910212, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
613141	15973	ENSG00000091073

Q86UW9

Protein name

Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)

Protein function

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental

PDB

6IR0 , 6Y22 , 6Y2X , 6Y3J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02825	WWE	20 → 97	WWE domain	Family
PF02825	WWE	110 → 174	WWE domain	Family
PF00097	zf-C3HC4	412 → 472	Zinc finger, C3HC4 type (RING finger)	Domain
PF18102	DTC	480 → 614	Deltex C-terminal domain	Domain

Sequence

MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLA
HSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGS
WTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPY
PVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGT
HQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSG
AVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTS
PPASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVPPDEDCIICMEKLS
TASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKT
GTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLP
DNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPN
YLQNVLAELAAQGVTEDCLEQQ

Sequence length

622

Interactions

View interactions

	KEGG		Reactome
	Notch signaling pathway		Activated NOTCH1 Transmits Signal to the Nucleus

DTX2 (deltex E3 ubiquitin ligase 2)