TUBA3D (tubulin alpha 3d)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
113457
Gene name Gene Name - the full gene name approved by the HGNC.
Tubulin alpha 3d
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TUBA3D
Synonyms (NCBI Gene) Gene synonyms aliases
H2-ALPHA, KTCN9, TUBA2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
KTCN9
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the alpha tubulin family. Tubulin is a major component of microtubules, which are composed of alpha- and beta-tubulin heterodimers and microtubule-associated proteins in the cytoskeleton. Microtubules maintain cellular struct
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT022328 hsa-miR-124-3p Microarray 18668037
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA 21873635
GO:0000278 Process Mitotic cell cycle IBA 21873635
GO:0003924 Function GTPase activity IEA
GO:0005200 Function Structural constituent of cytoskeleton IBA 21873635
GO:0005525 Function GTP binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
617878 24071 ENSG00000075886
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P0DPH8
Protein name Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain]
Protein function Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule en
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00091 Tubulin 3 → 214 Tubulin/FtsZ family, GTPase domain Domain
PF03953 Tubulin_C 263 → 393 Tubulin C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the cornea, sclera, and peripheral blood (PubMed:29051577). {ECO:0000269|PubMed:29051577}.
Sequence
Sequence length 450
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Phagosome
Apoptosis
Tight junction
Gap junction
Motor proteins
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Pathogenic Escherichia coli infection
Salmonella infection 		  Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Hedgehog 'off' state
Cilium Assembly
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Keratoconus KERATOCONUS 9 rs273585637, rs273585632, rs273585616, rs273585618, rs281865144, rs281865150, rs1553500862, rs756938019
Show/Hide Text Mining Associations (3)
Associations from Text Mining
Disease Name Relationship Type References
Cardiovascular Diseases Associate 30423812
Heart Septal Defects Ventricular Associate 30423812
Keratoconus Associate 29051577