Gene Gene information from NCBI Gene database.
Entrez ID 11343
Gene name Monoglyceride lipase
Gene symbol MGLL
Synonyms (NCBI Gene)
HU-K5HUK5MAGLMGL
Chromosome 3
Chromosome location 3q21.3
Summary This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and noci
miRNA miRNA information provided by mirtarbase database.
598
miRTarBase ID miRNA Experiments Reference
MIRT025844 hsa-miR-7-5p Microarray 19073608
MIRT047880 hsa-miR-30c-5p CLASH 23622248
MIRT437600 hsa-miR-142-3p MicroarrayqRT-PCR 22815788
MIRT437751 hsa-miR-93-5p MicroarrayqRT-PCR 22815788
MIRT702025 hsa-miR-624-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Phosphatidylcholine lysophospholipase activity TAS 9495531
GO:0005515 Function Protein binding IPI 28298427, 28514442, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0005829 Component Cytosol IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609699 17038 ENSG00000074416
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99685
Protein name Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL)
Protein function Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation
PDB 3HJU , 3JW8 , 3JWE , 3PE6 , 4UUQ , 5ZUN , 6AX1 , 6BQ0 , 7L4T , 7L4U , 7L4W , 7L50 , 7PRM , 7ZPG , 8AQF , 8PTC , 8PTQ , 8PTR , 8RVF , 9F8A , 9F8B , 9F8C , 9F8D , 9FY5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12146 Hydrolase_4 39 276 Serine aminopeptidase, S33 Family
Tissue specificity TISSUE SPECIFICITY: Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}.
Sequence
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycerolipid metabolism
Metabolic pathways
Thermogenesis
Retrograde endocannabinoid signaling
Regulation of lipolysis in adipocytes
  Acyl chain remodeling of DAG and TAG
Arachidonate production from DAG
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
10
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
MGLL-related disorder Benign; Likely benign rs201175620, rs375239037, rs4881, rs140105585, rs138122374, rs748034490, rs138910107, rs75396122, rs111794060, rs201794814 RCV003939052
RCV003911922
RCV003973889
RCV003911872
RCV003941746
RCV003934072
RCV003914558
RCV003914744
RCV003970666
RCV003943001
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 37959665
Adenocarcinoma of Lung Associate 32998690
Aortic Aneurysm Abdominal Associate 19233690
Azoospermia Associate 36733803
Breast Neoplasms Associate 34657876
Carcinogenesis Associate 22808421, 31357249
Carcinoma Hepatocellular Associate 27884159, 37403022
Carcinoma Pancreatic Ductal Associate 32899691
Carcinoma Renal Cell Associate 35633317
Colorectal Neoplasms Inhibit 22349814