Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11343
Gene name Gene Name - the full gene name approved by the HGNC.
Monoglyceride lipase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MGLL
Synonyms (NCBI Gene) Gene synonyms aliases
HU-K5, HUK5, MAGL, MGL
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and noci
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025844 hsa-miR-7-5p Microarray 19073608
MIRT047880 hsa-miR-30c-5p CLASH 23622248
MIRT437600 hsa-miR-142-3p Microarray, qRT-PCR 22815788
MIRT437751 hsa-miR-93-5p Microarray, qRT-PCR 22815788
MIRT702025 hsa-miR-624-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Lysophospholipase activity TAS 9495531
GO:0005515 Function Protein binding IPI 28298427
GO:0005654 Component Nucleoplasm IDA
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0005829 Component Cytosol ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609699 17038 ENSG00000074416
Protein
UniProt ID Q99685
Protein name Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL)
Protein function Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation
PDB 3HJU , 3JW8 , 3JWE , 3PE6 , 4UUQ , 5ZUN , 6AX1 , 6BQ0 , 7L4T , 7L4U , 7L4W , 7L50 , 7PRM , 7ZPG , 8AQF , 8PTC , 8PTQ , 8PTR , 8RVF , 9F8A , 9F8B , 9F8C , 9F8D , 9FY5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12146 Hydrolase_4 39 276 Serine aminopeptidase, S33 Family
Tissue specificity TISSUE SPECIFICITY: Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}.
Sequence
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerolipid metabolism
Metabolic pathways
Thermogenesis
Retrograde endocannabinoid signaling
Regulation of lipolysis in adipocytes
  Acyl chain remodeling of DAG and TAG
Arachidonate production from DAG
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
21799836
Metabolic syndrome Metabolic Syndrome X rs367643250, rs587777380, rs777736953 30621171
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 18924182
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Pelvic Organ Prolapse Pelvic Organ Prolapse GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 37959665
Adenocarcinoma of Lung Associate 32998690
Aortic Aneurysm Abdominal Associate 19233690
Azoospermia Associate 36733803
Breast Neoplasms Associate 34657876
Carcinogenesis Associate 22808421, 31357249
Carcinoma Hepatocellular Associate 27884159, 37403022
Carcinoma Pancreatic Ductal Associate 32899691
Carcinoma Renal Cell Associate 35633317
Colorectal Neoplasms Inhibit 22349814