MGLL (monoglyceride lipase)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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11343 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Monoglyceride lipase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MGLL |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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HU-K5, HUK5, MAGL, MGL |
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Chromosome
Chromosome number
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3 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q21.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and noci |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q99685 | ||||||||||
| Protein name | Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) | ||||||||||
| Protein function | Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation | ||||||||||
| PDB | 3HJU , 3JW8 , 3JWE , 3PE6 , 4UUQ , 5ZUN , 6AX1 , 6BQ0 , 7L4T , 7L4U , 7L4W , 7L50 , 7PRM , 7ZPG , 8AQF , 8PTC , 8PTQ , 8PTR , 8RVF , 9F8A , 9F8B , 9F8C , 9F8D , 9FY5 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}. | ||||||||||
| Sequence |
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| Sequence length | 303 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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