UniProt ID |
Q99685
|
Protein name |
Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) |
Protein function |
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation |
PDB |
3HJU
,
3JW8
,
3JWE
,
3PE6
,
4UUQ
,
5ZUN
,
6AX1
,
6BQ0
,
7L4T
,
7L4U
,
7L4W
,
7L50
,
7PRM
,
7ZPG
,
8AQF
,
8PTC
,
8PTQ
,
8PTR
,
8RVF
,
9F8A
,
9F8B
,
9F8C
,
9F8D
,
9FY5
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF12146
|
Hydrolase_4 |
39 → 276 |
Serine aminopeptidase, S33 |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}. |
Sequence |
|
Sequence length |
303 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Diabetes mellitus |
Diabetes Mellitus, Non-Insulin-Dependent |
rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261 View all (293 more) |
21799836 |
Metabolic syndrome |
Metabolic Syndrome X |
rs367643250, rs587777380, rs777736953 |
30621171 |
Osteoporosis |
Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis |
rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 |
18924182 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Schizophrenia |
Schizophrenia |
|
|
GWAS |
Metabolic Syndrome |
Metabolic Syndrome |
|
|
GWAS |
Prostate cancer |
Prostate cancer |
Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. |
|
GWAS, CBGDA |
Pelvic Organ Prolapse |
Pelvic Organ Prolapse |
|
|
GWAS |
Glioblastoma |
Glioblastoma |
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 |
|
GWAS, CBGDA |
Oligodendroglioma |
Oligodendroglioma |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Acute Kidney Injury |
Associate
|
37959665 |
Adenocarcinoma of Lung |
Associate
|
32998690 |
Aortic Aneurysm Abdominal |
Associate
|
19233690 |
Azoospermia |
Associate
|
36733803 |
Breast Neoplasms |
Associate
|
34657876 |
Carcinogenesis |
Associate
|
22808421, 31357249 |
Carcinoma Hepatocellular |
Associate
|
27884159, 37403022 |
Carcinoma Pancreatic Ductal |
Associate
|
32899691 |
Carcinoma Renal Cell |
Associate
|
35633317 |
Colorectal Neoplasms |
Inhibit
|
22349814 |
Colorectal Neoplasms |
Associate
|
36111743 |
Diabetes Gestational |
Inhibit
|
24262292 |
Endometrial Neoplasms |
Associate
|
31357249, 36550099 |
Gastrointestinal Stromal Tumors |
Associate
|
27366945 |
Glioblastoma |
Associate
|
31863022 |
Glioma |
Inhibit
|
22176552 |
Hemangioblastoma |
Associate
|
33446752 |
Heredodegenerative Disorders Nervous System |
Associate
|
33116203 |
Inflammation |
Associate
|
19543978, 20464001, 35522977, 37959665 |
Neoplasm Invasiveness |
Stimulate
|
31357249 |
Neoplasm Metastasis |
Stimulate
|
36550099 |
Neoplasms |
Associate
|
21802006, 27884159, 35522977, 37033945 |
Neoplasms |
Inhibit
|
22349814, 31423851 |
Neoplasms |
Stimulate
|
31357249, 36550099 |
Neurodegenerative Diseases |
Associate
|
19543978, 20464001, 35522977 |
Obesity |
Associate
|
21813022, 22262732, 24616451 |
Obesity Maternal |
Inhibit
|
24262292 |
Osteoarthritis |
Associate
|
39725154 |
Osteosarcoma |
Associate
|
35067491 |
Pain |
Associate
|
19543978, 20464001 |
Pancreatic Neoplasms |
Associate
|
17943729, 35522977 |
Parkinson Disease |
Associate
|
29352424 |
Progesterone Resistance |
Associate
|
36550099 |
Prostatic Neoplasms |
Associate
|
21802006 |
Squamous Cell Carcinoma of Head and Neck |
Inhibit
|
31423851 |
Uveal melanoma |
Associate
|
37033945 |
Wasting Syndrome |
Associate
|
37021483 |
|