Gene Gene information from NCBI Gene database.
Entrez ID 11329
Gene name Serine/threonine kinase 38
Gene symbol STK38
Synonyms (NCBI Gene)
NDRNDR1
Chromosome 6
Chromosome location 6p21.31
Summary This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cy
miRNA miRNA information provided by mirtarbase database.
1175
miRTarBase ID miRNA Experiments Reference
MIRT023042 hsa-miR-124-3p Microarray 18668037
MIRT027196 hsa-miR-103a-3p Sequencing 20371350
MIRT031271 hsa-miR-19b-3p Sequencing 20371350
MIRT031919 hsa-miR-16-5p Sequencing 20371350
MIRT052031 hsa-let-7b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IDA 30886146
GO:0000077 Process DNA damage checkpoint signaling IDA 32537488
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 12493777
GO:0000287 Function Magnesium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606964 17847 ENSG00000112079
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15208
Protein name Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)
Protein function Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits
PDB 1PSB , 6BXI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 89 382 Protein kinase domain Domain
PF00433 Pkinase_C 401 445 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:7761441}.
Sequence
Sequence length 465
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Bladder exstrophy-epispadias-cloacal extrophy complex Uncertain significance rs2532331322 RCV003389421
Primary dilated cardiomyopathy Uncertain significance rs1582441467 RCV000850355
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 33482886
Endometriosis Associate 40187212
Neoplasms Associate 18519667