Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11329
Gene name Gene Name - the full gene name approved by the HGNC.
Serine/threonine kinase 38
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STK38
Synonyms (NCBI Gene) Gene synonyms aliases
NDR, NDR1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cy
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023042 hsa-miR-124-3p Microarray 18668037
MIRT027196 hsa-miR-103a-3p Sequencing 20371350
MIRT031271 hsa-miR-19b-3p Sequencing 20371350
MIRT031919 hsa-miR-16-5p Sequencing 20371350
MIRT052031 hsa-let-7b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 12493777
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 12493777
GO:0005515 Function Protein binding IPI 9774336, 14661952, 15197186, 17620599, 18362890, 22939624, 25852190, 31980649, 32296183
GO:0005524 Function ATP binding IDA 12493777
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606964 17847 ENSG00000112079
Protein
UniProt ID Q15208
Protein name Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)
Protein function Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits
PDB 1PSB , 6BXI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 89 382 Protein kinase domain Domain
PF00433 Pkinase_C 401 445 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:7761441}.
Sequence
Sequence length 465
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Glaucoma Glaucoma GWAS
Uterine Fibroids Uterine Fibroids GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 33482886
Endometriosis Associate 40187212
Neoplasms Associate 18519667