KIF12 (kinesin family member 12)

Gene

• Entrez ID: 113220
• Gene name: Kinesin family member 12
• Gene symbol: KIF12
• Synonyms (NCBI Gene): PFIC8
• Disease Acronyms (UniProt): PFIC8
• Chromosome: 9
• Chromosome location: 9q32
• Summary: This gene encodes a member of the kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A simil

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1093208	hsa-miR-377	CLIP-seq
MIRT1093209	hsa-miR-4649-3p	CLIP-seq
MIRT1093210	hsa-miR-622	CLIP-seq
MIRT2024975	hsa-miR-15a	CLIP-seq
MIRT2024976	hsa-miR-15b	CLIP-seq
MIRT2024977	hsa-miR-16	CLIP-seq
MIRT2024978	hsa-miR-195	CLIP-seq
MIRT2024979	hsa-miR-424	CLIP-seq
MIRT2024980	hsa-miR-4524	CLIP-seq
MIRT2024981	hsa-miR-497	CLIP-seq
MIRT2024982	hsa-miR-503	CLIP-seq
MIRT2024983	hsa-miR-646	CLIP-seq
MIRT2256094	hsa-miR-136	CLIP-seq
MIRT2024975	hsa-miR-15a	CLIP-seq
MIRT2024976	hsa-miR-15b	CLIP-seq
MIRT2024977	hsa-miR-16	CLIP-seq
MIRT2024978	hsa-miR-195	CLIP-seq
MIRT2256095	hsa-miR-214	CLIP-seq
MIRT2256096	hsa-miR-3619-5p	CLIP-seq
MIRT2024979	hsa-miR-424	CLIP-seq
MIRT2256097	hsa-miR-4291	CLIP-seq
MIRT2256098	hsa-miR-4494	CLIP-seq
MIRT2256099	hsa-miR-4499	CLIP-seq
MIRT2024980	hsa-miR-4524	CLIP-seq
MIRT2256100	hsa-miR-4771	CLIP-seq
MIRT2024981	hsa-miR-497	CLIP-seq
MIRT2024982	hsa-miR-503	CLIP-seq
MIRT2256101	hsa-miR-626	CLIP-seq
MIRT2024983	hsa-miR-646	CLIP-seq
MIRT2256102	hsa-miR-761	CLIP-seq
MIRT2256103	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0003777	Function	Microtubule motor activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005871	Component	Kinesin complex	IBA	21873635
GO:0005874	Component	Microtubule	IBA	21873635
GO:0007018	Process	Microtubule-based movement	IBA	21873635
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0008150	Process	Biological_process	ND
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070062	Component	Extracellular exosome	IDA	21082674

Other IDs

• MIM: 611278
• HGNC: 21495
• e!Ensembl: ENSG00000136883

Protein

• UniProt ID: Q96FN5
• Protein name: Kinesin-like protein KIF12
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	31 → 360	Kinesin motor domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus cancer and pancreatic cancer. {ECO:0000269|PubMed:15643526}.
• Sequence:

  MEERGSPDGDLARSLEQGPEGPETPIQVVLRVRPMSAAELRRGQQSVLHCSGTRTLQGGP
  EVAFRFGAVLDAARTQEDVFRACGVRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQ
  GEGVPVPPSLAGIMQRTFAWLLDRVQHLGAPVTLRASYLEIYNEQVRDLLSLGSPRPLPV
  RWNKTRGFYVEQLRVVEFGSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYISRQ
  TAQQMPSVDPGEPPVGGKLCFVDLAGSEKVAATGSRGELMLEANSINRSLLALGHCISLL
  LDPQRKQSHIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRV
  TTRPQAPKSPVAKQPQRLETEMLQLQEENRRLQFQLDQMDCKASGLSGARVAWAQRNLYG
  MLQEFMLENERLRKEKSQLQNSRDLAQNEQRILAQQVHALERRLLSACYHHQQGPGLTPP
  CPCLMAPAPPCHALPPLYSCPCCHICPLCRVPLAHWACLPGEHHLPQVLDPEASGGRPPS
  ARPPPWAPPCSPGSAKCPRERSHSDWTQTRVLAEMLTEEEVVPSAPPLPVRPPKTSPGLR
  GGAGVPNLAQRLEALRDQIGSSLRRGRSQPPCSEGARSPGQVLPPH

• Sequence length: 646

Pathways

KEGG:

Motor proteins

Reactome:

COPI-dependent Golgi-to-ER retrograde traffic
Kinesins

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Coronary heart disease	Coronary heart disease		23364394	ClinVar
Cholestasis	cholestasis, progressive familial intrahepatic, 8			GenCC

Associations from Text Mining
Disease Name	Relationship Type	References
Bile Duct Diseases	Associate	30250217
Breast Neoplasms	Associate	21479552
Cakut	Associate	36830709
Cholangitis Sclerosing	Associate	30250217
Cholestasis	Associate	34555379
Liver Diseases	Associate	30250217, 34555379