Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11320
Gene name Gene Name - the full gene name approved by the HGNC.
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MGAT4A
Synonyms (NCBI Gene) Gene synonyms aliases
GNT-IV, GNT-IVA, GnT-4a
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (Gl
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016995 hsa-miR-335-5p Microarray 18185580
MIRT030689 hsa-miR-21-5p Microarray 18591254
MIRT031454 hsa-miR-16-5p Sequencing 20371350
MIRT513378 hsa-miR-5582-5p PAR-CLIP 23446348
MIRT513377 hsa-miR-3622a-5p PAR-CLIP 23446348
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0005783 Component Endoplasmic reticulum IBA 21873635
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0005793 Component Endoplasmic reticulum-Golgi intermediate compartment IBA 21873635
GO:0005795 Component Golgi stack IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604623 7047 ENSG00000071073
Protein
UniProt ID Q9UM21
Protein name Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine:
Protein function Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-lin
PDB 7XTL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04666 Glyco_transf_54 86 380 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. {ECO:0000269|PubMed:1002466
Sequence
MRLRNGTVATALAFITSFLTLSWYTTWQNGKEKLIAYQREFLALKERLRIAEHRISQRSS
ELNTIVQQFKRVGAETNGSKDALNKFSDNTLKLLKELTSKKSLQVPSIYYHLPHLLKNEG
SLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGET
DIDYVHGVVANLEKEFSKEISSGLVEVISPPESYYPDLTNLKETFGDSKERVRWRTKQNL
DYCFLMMYAQEKGIYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMF
QAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQ
HVGLHSSLSGKIQKLTDKDY
MKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWA
ITPIAGDYILFKFDKPVNVESYLFHSGNQEHPGDILLNTTVEVLPFKSEGLEISKETKDK
RLEDGYFRIGKFENGVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKKATN
Sequence length 535
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
  Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
N-Glycan antennae elongation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal neoplasms Secondary malignant neoplasm of colon and/or rectum rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
26222057
Hypoplastic left heart syndrome HYPOPLASTIC LEFT HEART SYNDROME 1, HYPOPLASTIC LEFT HEART SYNDROME 2 rs1554284604, rs1843006535 28468790
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Sarcoidosis Sarcoidosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acquired ichthyosis Associate 36303457
Autism Spectrum Disorder Associate 36320054
Bipolar Disorder Associate 22212596
Carcinoma Hepatocellular Stimulate 26537865
Choriocarcinoma Associate 23169300
Colorectal Neoplasms Associate 36303457
Diabetes Mellitus Type 1 Associate 36303457
Diabetes Mellitus Type 2 Stimulate 17953760
Hydatidiform Mole Invasive Stimulate 23169300
Infertility Associate 36303457