Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	11259
Gene name	Filamin A interacting protein 1 like
Gene symbol	FILIP1L
Synonyms (NCBI Gene)	DOC-1DOC1GIP130GIP90
Chromosome	3
Chromosome location	3q12.1

Show/Hide all (29)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018948	hsa-miR-335-5p	Microarray	18185580
MIRT031073	hsa-miR-21-5p	Microarray	20371350
MIRT031073	hsa-miR-21-5p	Microarray	18591254
MIRT996921	hsa-miR-1243	CLIP-seq
MIRT996922	hsa-miR-1255a	CLIP-seq
MIRT996923	hsa-miR-1255b	CLIP-seq
MIRT996924	hsa-miR-1269	CLIP-seq
MIRT996925	hsa-miR-1269b	CLIP-seq
MIRT996926	hsa-miR-1288	CLIP-seq
MIRT996927	hsa-miR-4515	CLIP-seq
MIRT996928	hsa-miR-4740-5p	CLIP-seq
MIRT996929	hsa-miR-4792	CLIP-seq
MIRT996930	hsa-miR-106a	CLIP-seq
MIRT996931	hsa-miR-106b	CLIP-seq
MIRT996932	hsa-miR-17	CLIP-seq
MIRT996933	hsa-miR-197	CLIP-seq
MIRT996934	hsa-miR-20a	CLIP-seq
MIRT996935	hsa-miR-20b	CLIP-seq
MIRT996936	hsa-miR-3174	CLIP-seq
MIRT996937	hsa-miR-3609	CLIP-seq
MIRT996938	hsa-miR-4424	CLIP-seq
MIRT996939	hsa-miR-4796-3p	CLIP-seq
MIRT996940	hsa-miR-5096	CLIP-seq
MIRT996941	hsa-miR-519d	CLIP-seq
MIRT996942	hsa-miR-548ah	CLIP-seq
MIRT996943	hsa-miR-93	CLIP-seq
MIRT2229626	hsa-miR-1206	CLIP-seq
MIRT2229627	hsa-miR-568	CLIP-seq
MIRT2229628	hsa-miR-643	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0016020	Component	Membrane	IEA
GO:1903119	Process	Protein localization to actin cytoskeleton	IBA

MIM	HGNC	e!Ensembl
612993	24589	ENSG00000168386

Q4L180

Protein name

Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)

Protein function

Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tu

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09727	CortBP2	63 → 248	Cortactin-binding protein-2	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian

Sequence

MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN
GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ
RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR
KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL
MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVEPLLLPH

Sequence length

1135

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
FILIP1L-related disorder	Likely benign; Benign; Uncertain significance	rs780442992, rs793440, rs191193772, rs9843741, rs114299850, rs13353487, rs371654121, rs201896358, rs141449044, rs140594225, rs538097692, rs9828782, rs1273023605, rs36005744, rs148447244, rs201828035, rs745635964, rs377049900 View all (3 more)	RCV003981736 RCV003967416 RCV003903835 RCV003911666 RCV003961796 RCV003964066 RCV003931692 RCV003943842 RCV003914514 RCV003949371 RCV003951364 RCV003969291 RCV003961957 RCV003922137 RCV003949191 RCV003954364 RCV003963828 RCV003963856

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	36499753
Carcinogenesis	Associate	27750216
Cleft Lip	Associate	23512105
Cleft Palate	Associate	23512105
Colorectal Neoplasms	Associate	27750216
Lymphatic Metastasis	Inhibit	27750216
Macular Degeneration	Associate	23455636
Neoplasm Metastasis	Inhibit	24327474
Neoplasms	Inhibit	21693594, 22900064, 24327474, 24340050, 27750216
Neoplasms	Associate	23174249
Ovarian Neoplasms	Inhibit	21693594, 22900064
Ovarian Neoplasms	Associate	24327474, 24340050
Prostatic Neoplasms	Inhibit	23174249
Prostatic Neoplasms	Associate	34198725
Triple Negative Breast Neoplasms	Associate	36499753
Urinary Bladder Neoplasms	Associate	38552852

FILIP1L (filamin A interacting protein 1 like)