Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11252
Gene name Gene Name - the full gene name approved by the HGNC.	Protein kinase C and casein kinase substrate in neurons 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PACSIN2
Synonyms (NCBI Gene) Gene synonyms aliases	SDPII
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in mul

Show/Hide all(107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020597	hsa-miR-155-5p	Proteomics	18668040
MIRT041342	hsa-miR-193b-3p	CLASH	23622248
MIRT461118	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT461117	hsa-miR-3681-5p	PAR-CLIP	23592263
MIRT461116	hsa-miR-6849-5p	PAR-CLIP	23592263
MIRT461115	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT461114	hsa-miR-1286	PAR-CLIP	23592263
MIRT461113	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT461112	hsa-miR-6124	PAR-CLIP	23592263
MIRT461111	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT447675	hsa-miR-548av-3p	PAR-CLIP	22100165
MIRT447674	hsa-miR-548g-3p	PAR-CLIP	22100165
MIRT447673	hsa-miR-548u	PAR-CLIP	22100165
MIRT447671	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT447672	hsa-miR-8087	PAR-CLIP	22100165
MIRT447675	hsa-miR-548av-3p	PAR-CLIP	22100165
MIRT447674	hsa-miR-548g-3p	PAR-CLIP	22100165
MIRT447673	hsa-miR-548u	PAR-CLIP	22100165
MIRT447671	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT447672	hsa-miR-8087	PAR-CLIP	22100165
MIRT461118	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT461117	hsa-miR-3681-5p	PAR-CLIP	23592263
MIRT461116	hsa-miR-6849-5p	PAR-CLIP	23592263
MIRT461115	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT461114	hsa-miR-1286	PAR-CLIP	23592263
MIRT461113	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT461112	hsa-miR-6124	PAR-CLIP	23592263
MIRT461111	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT447675	hsa-miR-548av-3p	PAR-CLIP	22100165
MIRT447674	hsa-miR-548g-3p	PAR-CLIP	22100165
MIRT447673	hsa-miR-548u	PAR-CLIP	22100165
MIRT447671	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT447672	hsa-miR-8087	PAR-CLIP	22100165
MIRT447675	hsa-miR-548av-3p	PAR-CLIP	22100165
MIRT447674	hsa-miR-548g-3p	PAR-CLIP	22100165
MIRT447673	hsa-miR-548u	PAR-CLIP	22100165
MIRT447671	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT447672	hsa-miR-8087	PAR-CLIP	22100165
MIRT1210122	hsa-miR-1238	CLIP-seq
MIRT1210123	hsa-miR-3671	CLIP-seq
MIRT1210124	hsa-miR-4422	CLIP-seq
MIRT1210125	hsa-miR-4427	CLIP-seq
MIRT1210126	hsa-miR-4509	CLIP-seq
MIRT1210127	hsa-miR-4680-3p	CLIP-seq
MIRT1210128	hsa-miR-4744	CLIP-seq
MIRT1210129	hsa-miR-586	CLIP-seq
MIRT1210130	hsa-miR-4474-5p	CLIP-seq
MIRT1210131	hsa-miR-4714-5p	CLIP-seq
MIRT1210132	hsa-miR-4764-3p	CLIP-seq
MIRT1210133	hsa-miR-4778-3p	CLIP-seq
MIRT1210134	hsa-miR-618	CLIP-seq
MIRT1210135	hsa-miR-1471	CLIP-seq
MIRT1210136	hsa-miR-216a	CLIP-seq
MIRT1210137	hsa-miR-320a	CLIP-seq
MIRT1210138	hsa-miR-320b	CLIP-seq
MIRT1210139	hsa-miR-320c	CLIP-seq
MIRT1210140	hsa-miR-320d	CLIP-seq
MIRT1210141	hsa-miR-3679-3p	CLIP-seq
MIRT1210142	hsa-miR-4429	CLIP-seq
MIRT1210125	hsa-miR-4427	CLIP-seq
MIRT2060256	hsa-miR-128	CLIP-seq
MIRT2060257	hsa-miR-555	CLIP-seq
MIRT2288649	hsa-miR-329	CLIP-seq
MIRT2288650	hsa-miR-362-3p	CLIP-seq
MIRT2288651	hsa-miR-3941	CLIP-seq
MIRT2288652	hsa-miR-603	CLIP-seq
MIRT2288653	hsa-miR-1185	CLIP-seq
MIRT2288654	hsa-miR-3605-5p	CLIP-seq
MIRT2288655	hsa-miR-3679-5p	CLIP-seq
MIRT2392043	hsa-miR-1908	CLIP-seq
MIRT2392044	hsa-miR-3180	CLIP-seq
MIRT2392045	hsa-miR-3180-3p	CLIP-seq
MIRT2392046	hsa-miR-3184	CLIP-seq
MIRT2392047	hsa-miR-3196	CLIP-seq
MIRT2392048	hsa-miR-423-5p	CLIP-seq
MIRT2392049	hsa-miR-4706	CLIP-seq
MIRT2392050	hsa-miR-4728-5p	CLIP-seq
MIRT2392051	hsa-miR-4749-5p	CLIP-seq
MIRT2392052	hsa-miR-663	CLIP-seq
MIRT2442440	hsa-miR-1178	CLIP-seq
MIRT2442441	hsa-miR-1257	CLIP-seq
MIRT2442442	hsa-miR-3617	CLIP-seq
MIRT2442443	hsa-miR-4261	CLIP-seq
MIRT2442444	hsa-miR-4436b-5p	CLIP-seq
MIRT2442445	hsa-miR-451b	CLIP-seq
MIRT2442446	hsa-miR-4686	CLIP-seq
MIRT2442447	hsa-miR-4696	CLIP-seq
MIRT2442448	hsa-miR-641	CLIP-seq
MIRT2442449	hsa-miR-767-3p	CLIP-seq
MIRT2442450	hsa-miR-875-3p	CLIP-seq
MIRT2455796	hsa-miR-1179	CLIP-seq
MIRT2455797	hsa-miR-1276	CLIP-seq
MIRT2442440	hsa-miR-1178	CLIP-seq
MIRT2442441	hsa-miR-1257	CLIP-seq
MIRT2442443	hsa-miR-4261	CLIP-seq
MIRT2442449	hsa-miR-767-3p	CLIP-seq
MIRT2442450	hsa-miR-875-3p	CLIP-seq
MIRT2442440	hsa-miR-1178	CLIP-seq
MIRT2442442	hsa-miR-3617	CLIP-seq
MIRT2442443	hsa-miR-4261	CLIP-seq
MIRT2442444	hsa-miR-4436b-5p	CLIP-seq
MIRT2442445	hsa-miR-451b	CLIP-seq
MIRT2442446	hsa-miR-4686	CLIP-seq
MIRT2442447	hsa-miR-4696	CLIP-seq
MIRT2442448	hsa-miR-641	CLIP-seq
MIRT2442449	hsa-miR-767-3p	CLIP-seq
MIRT2442450	hsa-miR-875-3p	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005215	Function	Transporter activity	TAS	10431838
GO:0005515	Function	Protein binding	IPI	16189514, 16318909, 16551695, 20936779, 21044950, 23596323, 25036101, 25416956, 31413325, 32296183
GO:0005543	Function	Phospholipid binding	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005768	Component	Endosome	IBA	21873635
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005901	Component	Caveola	IDA	21610094, 24013648
GO:0005911	Component	Cell-cell junction	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007010	Process	Cytoskeleton organization	IBA	21873635
GO:0016607	Component	Nuclear speck	IDA
GO:0019898	Component	Extrinsic component of membrane	ISS
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030100	Process	Regulation of endocytosis	IBA	21873635
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0036010	Process	Protein localization to endosome	IMP	23596323
GO:0042802	Function	Identical protein binding	IPI	16189514, 20188097, 25416956, 31515488, 32296183
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045806	Process	Negative regulation of endocytosis	IEA
GO:0048858	Process	Cell projection morphogenesis	ISS
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0055038	Component	Recycling endosome membrane	IDA	23596323
GO:0061024	Process	Membrane organization	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070300	Function	Phosphatidic acid binding	IDA	23596323
GO:0070836	Process	Caveola assembly	IMP	21610094
GO:0072584	Process	Caveolin-mediated endocytosis	IMP	21610094
GO:0097320	Process	Plasma membrane tubulation	IBA	21873635
GO:0097320	Process	Plasma membrane tubulation	IDA	23596323
GO:0097320	Process	Plasma membrane tubulation	ISS
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
604960	8571	ENSG00000100266

Protein

UniProt ID

Q9UNF0

Protein name

Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)

Protein function

Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-me

PDB

3ABH , 3ACO , 3HAJ , 3Q0K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00611	FCH	23 → 99	Fes/CIP4, and EFC/F-BAR homology domain	Family
PF00018	SH3_1	432 → 479	SH3 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}.

Sequence

MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLT
EWARRWRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAF
HKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADP
SLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKR
LRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQ
FEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQSS
YNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFD
DDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPAN
YVEAIQ

Sequence length

486

Interactions

View interactions

	Reactome
			Clathrin-mediated endocytosis

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Metabolic Syndrome	Metabolic Syndrome			GWAS

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	36672180
Blast Crisis	Associate	35352878
Brain Diseases	Associate	36672180
Depressive Disorder Major	Associate	36672180
Diabetes Mellitus Type 2	Associate	32041280
Drug Related Side Effects and Adverse Reactions	Associate	27452984
Gastrointestinal Diseases	Associate	22846425, 31792371
Hematologic Diseases	Associate	27452984, 31792371
Inflammatory Bowel Diseases	Associate	31792371
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	35352878
Lung Neoplasms	Associate	34684727
Neoplasms	Associate	37132654
Norrie disease	Associate	32041280
Parkinson Disease	Associate	36672180
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	27452984
Stomatitis	Associate	27452984

PACSIN2 (protein kinase C and casein kinase substrate in neurons 2)