Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11250
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 45
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR45
Synonyms (NCBI Gene) Gene synonyms aliases	PSP24, PSP24(ALPHA), PSP24-1, PSP24-alpha, PSP24A
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrim

Show/Hide all(105)

miRTarBase ID	miRNA	Experiments	Reference
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT639778	hsa-miR-3938	HITS-CLIP	23824327
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639776	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639773	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639770	hsa-miR-1913	HITS-CLIP	23824327
MIRT639769	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639763	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT639762	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT639778	hsa-miR-3938	HITS-CLIP	23824327
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639776	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639773	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639770	hsa-miR-1913	HITS-CLIP	23824327
MIRT639769	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639763	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT639762	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT1031501	hsa-miR-1910	CLIP-seq
MIRT1031502	hsa-miR-1976	CLIP-seq
MIRT1031503	hsa-miR-3189-5p	CLIP-seq
MIRT1031504	hsa-miR-4722-3p	CLIP-seq
MIRT1031505	hsa-miR-4758-3p	CLIP-seq
MIRT2450631	hsa-miR-1207-3p	CLIP-seq
MIRT2450632	hsa-miR-22	CLIP-seq
MIRT2450633	hsa-miR-3127-3p	CLIP-seq
MIRT2450634	hsa-miR-4749-3p	CLIP-seq
MIRT2450635	hsa-miR-663b	CLIP-seq
MIRT2450636	hsa-miR-942	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
604838	4503	ENSG00000135973

Protein

UniProt ID

Q9Y5Y3

Protein name

Probable G-protein coupled receptor 45 (PSP24-1) (PSP24-alpha)

Protein function

Orphan receptor. May play a role in brain function.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	51 → 324	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.

Sequence

MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVY
QRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLE
GVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAP
QCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQ
LTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS
SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPS
TVYVCNENQSAV

Sequence length

372

Interactions

View interactions

	Reactome
			G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Cervical Cancer	Cervical cancer	N/A	N/A	GWAS
Cone-rod dystrophy	cone-rod dystrophy	N/A	N/A	GenCC
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Preeclampsia	Preeclampsia	N/A	N/A	GWAS

GPR45 (G protein-coupled receptor 45)