Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11250
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 45
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR45
Synonyms (NCBI Gene) Gene synonyms aliases	PSP24, PSP24(ALPHA), PSP24-1, PSP24-alpha, PSP24A
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrim

Show/Hide all(105)

miRTarBase ID	miRNA	Experiments	Reference
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT639778	hsa-miR-3938	HITS-CLIP	23824327
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639776	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639773	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639770	hsa-miR-1913	HITS-CLIP	23824327
MIRT639769	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639763	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT639762	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT639778	hsa-miR-3938	HITS-CLIP	23824327
MIRT639777	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT639776	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT639775	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT639774	hsa-miR-5193	HITS-CLIP	23824327
MIRT639773	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639772	hsa-miR-4287	HITS-CLIP	23824327
MIRT639771	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639770	hsa-miR-1913	HITS-CLIP	23824327
MIRT639769	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT639768	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT639767	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT639766	hsa-miR-4290	HITS-CLIP	23824327
MIRT639765	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT639764	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT639763	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT639762	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT639761	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT639760	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT639759	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639758	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT639757	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT639756	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT639755	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT639754	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT639753	hsa-miR-544a	HITS-CLIP	23824327
MIRT639752	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT1031501	hsa-miR-1910	CLIP-seq
MIRT1031502	hsa-miR-1976	CLIP-seq
MIRT1031503	hsa-miR-3189-5p	CLIP-seq
MIRT1031504	hsa-miR-4722-3p	CLIP-seq
MIRT1031505	hsa-miR-4758-3p	CLIP-seq
MIRT2450631	hsa-miR-1207-3p	CLIP-seq
MIRT2450632	hsa-miR-22	CLIP-seq
MIRT2450633	hsa-miR-3127-3p	CLIP-seq
MIRT2450634	hsa-miR-4749-3p	CLIP-seq
MIRT2450635	hsa-miR-663b	CLIP-seq
MIRT2450636	hsa-miR-942	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0016021	Component	Integral component of membrane	IEA

MIM	HGNC	e!Ensembl
604838	4503	ENSG00000135973

Protein

UniProt ID

Q9Y5Y3

Protein name

Probable G-protein coupled receptor 45 (PSP24-1) (PSP24-alpha)

Protein function

Orphan receptor. May play a role in brain function.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	51 → 324	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.

Sequence

MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVY
QRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLE
GVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAP
QCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQ
LTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS
SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPS
TVYVCNENQSAV

Sequence length

372

Interactions

View interactions

	Reactome
			G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Cone-rod dystrophy	cone-rod dystrophy		GenCC
Preeclampsia	Preeclampsia		GWAS
Diabetes	Diabetes		GWAS
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).	GWAS, CBGDA

GPR45 (G protein-coupled receptor 45)