KLK8 (kallikrein related peptidase 8)

Gene
Gene Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11202
Gene name Gene Name - the full gene name approved by the HGNC.
Kallikrein related peptidase 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KLK8
Synonyms (NCBI Gene) Gene synonyms aliases
HNP, NP, NRPN, PRSS19, TADG14
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.41
Summary Summary of gene provided in NCBI Entrez Gene.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways
Show/Hide all(19)
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IDA 16337200
GO:0005515 Function Protein binding IPI 17761692, 19194479, 24705354, 25416956, 32296183, 32814053
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space ISS
GO:0005737 Component Cytoplasm IDA 17761692
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
605644 6369 ENSG00000129455
Protein
Gene Gene ontology Other IDs Protein Pathways
UniProt ID O60259
Protein name Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)
Protein function Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation
PDB 5MS3 , 5MS4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 33 → 252 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and
Sequence
Sequence length 260
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways
  Reactome
    Formation of the cornified envelope