Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11201
Gene name Gene Name - the full gene name approved by the HGNC.	DNA polymerase iota
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	POLI
Synonyms (NCBI Gene) Gene synonyms aliases	RAD30B, RAD3OB, eta2
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q21.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides acr

Show/Hide all(249)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049053	hsa-miR-92a-3p	CLASH	23622248
MIRT497086	hsa-miR-455-5p	PAR-CLIP	22291592
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22291592
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22291592
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22291592
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22291592
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22291592
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22291592
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22291592
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22291592
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22291592
MIRT497085	hsa-miR-376a-5p	PAR-CLIP	22291592
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22291592
MIRT450742	hsa-miR-3672	PAR-CLIP	22291592
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22291592
MIRT290698	hsa-miR-548aw	PAR-CLIP	22291592
MIRT290697	hsa-miR-4760-5p	PAR-CLIP	22291592
MIRT290699	hsa-miR-8061	PAR-CLIP	22291592
MIRT450753	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT450752	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT199034	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT199032	hsa-miR-4255	PAR-CLIP	22100165
MIRT199031	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT450751	hsa-miR-889-3p	PAR-CLIP	22100165
MIRT199033	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22100165
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22100165
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22100165
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22100165
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22100165
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22100165
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22100165
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22100165
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22100165
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT450742	hsa-miR-3672	PAR-CLIP	22100165
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT290698	hsa-miR-548aw	PAR-CLIP	22100165
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	27292025
MIRT497086	hsa-miR-455-5p	PAR-CLIP	22291592
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22291592
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22291592
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22291592
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22291592
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22291592
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22291592
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22291592
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22291592
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22291592
MIRT497085	hsa-miR-376a-5p	PAR-CLIP	22291592
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22291592
MIRT450742	hsa-miR-3672	PAR-CLIP	22291592
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22291592
MIRT290698	hsa-miR-548aw	PAR-CLIP	22291592
MIRT290697	hsa-miR-4760-5p	PAR-CLIP	22291592
MIRT290699	hsa-miR-8061	PAR-CLIP	22291592
MIRT450753	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT450752	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT199034	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT199032	hsa-miR-4255	PAR-CLIP	22100165
MIRT199031	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT450751	hsa-miR-889-3p	PAR-CLIP	22100165
MIRT199033	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22100165
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22100165
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22100165
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22100165
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22100165
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22100165
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22100165
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22100165
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22100165
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT450742	hsa-miR-3672	PAR-CLIP	22100165
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT290698	hsa-miR-548aw	PAR-CLIP	22100165
MIRT1247913	hsa-miR-1271	CLIP-seq
MIRT1247914	hsa-miR-1273	CLIP-seq
MIRT1247915	hsa-miR-1273e	CLIP-seq
MIRT1247916	hsa-miR-1276	CLIP-seq
MIRT1247917	hsa-miR-1298	CLIP-seq
MIRT1247918	hsa-miR-139-5p	CLIP-seq
MIRT1247919	hsa-miR-1537	CLIP-seq
MIRT1247920	hsa-miR-181a	CLIP-seq
MIRT1247921	hsa-miR-181b	CLIP-seq
MIRT1247922	hsa-miR-181c	CLIP-seq
MIRT1247923	hsa-miR-181d	CLIP-seq
MIRT1247924	hsa-miR-182	CLIP-seq
MIRT1247925	hsa-miR-1827	CLIP-seq
MIRT1247926	hsa-miR-194	CLIP-seq
MIRT1247927	hsa-miR-224	CLIP-seq
MIRT1247928	hsa-miR-23a	CLIP-seq
MIRT1247929	hsa-miR-23b	CLIP-seq
MIRT1247930	hsa-miR-23c	CLIP-seq
MIRT1247931	hsa-miR-2964a-3p	CLIP-seq
MIRT1247932	hsa-miR-302f	CLIP-seq
MIRT1247933	hsa-miR-3120-5p	CLIP-seq
MIRT1247934	hsa-miR-3143	CLIP-seq
MIRT1247935	hsa-miR-3145-5p	CLIP-seq
MIRT1247936	hsa-miR-3160-3p	CLIP-seq
MIRT1247937	hsa-miR-3174	CLIP-seq
MIRT1247938	hsa-miR-3192	CLIP-seq
MIRT1247939	hsa-miR-3200-3p	CLIP-seq
MIRT1247940	hsa-miR-335	CLIP-seq
MIRT1247941	hsa-miR-3605-5p	CLIP-seq
MIRT1247942	hsa-miR-3620	CLIP-seq
MIRT1247943	hsa-miR-3664-5p	CLIP-seq
MIRT1247944	hsa-miR-3689a-3p	CLIP-seq
MIRT1247945	hsa-miR-3689c	CLIP-seq
MIRT1247946	hsa-miR-3929	CLIP-seq
MIRT1247947	hsa-miR-4252	CLIP-seq
MIRT1247948	hsa-miR-4262	CLIP-seq
MIRT1247949	hsa-miR-4292	CLIP-seq
MIRT1247950	hsa-miR-4311	CLIP-seq
MIRT1247951	hsa-miR-4419b	CLIP-seq
MIRT1247952	hsa-miR-4459	CLIP-seq
MIRT1247953	hsa-miR-4478	CLIP-seq
MIRT1247954	hsa-miR-4486	CLIP-seq
MIRT1247955	hsa-miR-4487	CLIP-seq
MIRT1247956	hsa-miR-4522	CLIP-seq
MIRT1247957	hsa-miR-4649-3p	CLIP-seq
MIRT1247958	hsa-miR-4649-5p	CLIP-seq
MIRT1247959	hsa-miR-4662a-5p	CLIP-seq
MIRT1247960	hsa-miR-4668-5p	CLIP-seq
MIRT1247961	hsa-miR-4695-5p	CLIP-seq
MIRT1247962	hsa-miR-4722-5p	CLIP-seq
MIRT1247963	hsa-miR-4728-5p	CLIP-seq
MIRT1247964	hsa-miR-4747-3p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT1247966	hsa-miR-4797-5p	CLIP-seq
MIRT1247967	hsa-miR-485-5p	CLIP-seq
MIRT1247968	hsa-miR-490-3p	CLIP-seq
MIRT1247969	hsa-miR-508-5p	CLIP-seq
MIRT1247970	hsa-miR-515-5p	CLIP-seq
MIRT1247971	hsa-miR-543	CLIP-seq
MIRT1247972	hsa-miR-558	CLIP-seq
MIRT1247973	hsa-miR-583	CLIP-seq
MIRT1247974	hsa-miR-658	CLIP-seq
MIRT1247975	hsa-miR-664	CLIP-seq
MIRT1247976	hsa-miR-888	CLIP-seq
MIRT1247977	hsa-miR-889	CLIP-seq
MIRT1247978	hsa-miR-921	CLIP-seq
MIRT1247979	hsa-miR-940	CLIP-seq
MIRT1247980	hsa-miR-96	CLIP-seq
MIRT1247915	hsa-miR-1273e	CLIP-seq
MIRT1247925	hsa-miR-1827	CLIP-seq
MIRT2073174	hsa-miR-190	CLIP-seq
MIRT2073175	hsa-miR-190b	CLIP-seq
MIRT1247931	hsa-miR-2964a-3p	CLIP-seq
MIRT1247932	hsa-miR-302f	CLIP-seq
MIRT1247936	hsa-miR-3160-3p	CLIP-seq
MIRT2073176	hsa-miR-3160-5p	CLIP-seq
MIRT1247937	hsa-miR-3174	CLIP-seq
MIRT1247938	hsa-miR-3192	CLIP-seq
MIRT2073177	hsa-miR-3664-3p	CLIP-seq
MIRT1247944	hsa-miR-3689a-3p	CLIP-seq
MIRT1247945	hsa-miR-3689c	CLIP-seq
MIRT1247946	hsa-miR-3929	CLIP-seq
MIRT1247951	hsa-miR-4419b	CLIP-seq
MIRT2073178	hsa-miR-4433	CLIP-seq
MIRT1247952	hsa-miR-4459	CLIP-seq
MIRT1247953	hsa-miR-4478	CLIP-seq
MIRT1247955	hsa-miR-4487	CLIP-seq
MIRT2073179	hsa-miR-4520a-3p	CLIP-seq
MIRT2073180	hsa-miR-4520b-3p	CLIP-seq
MIRT1247957	hsa-miR-4649-3p	CLIP-seq
MIRT1247961	hsa-miR-4695-5p	CLIP-seq
MIRT1247962	hsa-miR-4722-5p	CLIP-seq
MIRT1247963	hsa-miR-4728-5p	CLIP-seq
MIRT2073181	hsa-miR-4753-3p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT2073182	hsa-miR-4768-5p	CLIP-seq
MIRT1247967	hsa-miR-485-5p	CLIP-seq
MIRT1247968	hsa-miR-490-3p	CLIP-seq
MIRT2073183	hsa-miR-510	CLIP-seq
MIRT2073184	hsa-miR-512-5p	CLIP-seq
MIRT2073185	hsa-miR-526b	CLIP-seq
MIRT1247972	hsa-miR-558	CLIP-seq
MIRT2073186	hsa-miR-578	CLIP-seq
MIRT1247973	hsa-miR-583	CLIP-seq
MIRT1247974	hsa-miR-658	CLIP-seq
MIRT2073187	hsa-miR-890	CLIP-seq
MIRT1247978	hsa-miR-921	CLIP-seq
MIRT2073188	hsa-miR-935	CLIP-seq
MIRT1247979	hsa-miR-940	CLIP-seq
MIRT2300290	hsa-miR-1295	CLIP-seq
MIRT2300291	hsa-miR-1299	CLIP-seq
MIRT2300292	hsa-miR-1303	CLIP-seq
MIRT2300293	hsa-miR-15a	CLIP-seq
MIRT2300294	hsa-miR-15b	CLIP-seq
MIRT2300295	hsa-miR-16	CLIP-seq
MIRT1247925	hsa-miR-1827	CLIP-seq
MIRT2300296	hsa-miR-195	CLIP-seq
MIRT2300297	hsa-miR-3126-3p	CLIP-seq
MIRT2300298	hsa-miR-3140-3p	CLIP-seq
MIRT1247936	hsa-miR-3160-3p	CLIP-seq
MIRT1247937	hsa-miR-3174	CLIP-seq
MIRT1247938	hsa-miR-3192	CLIP-seq
MIRT1247944	hsa-miR-3689a-3p	CLIP-seq
MIRT1247945	hsa-miR-3689c	CLIP-seq
MIRT1247946	hsa-miR-3929	CLIP-seq
MIRT2300299	hsa-miR-424	CLIP-seq
MIRT2300300	hsa-miR-4253	CLIP-seq
MIRT2300301	hsa-miR-4279	CLIP-seq
MIRT1247951	hsa-miR-4419b	CLIP-seq
MIRT2300302	hsa-miR-4422	CLIP-seq
MIRT2073178	hsa-miR-4433	CLIP-seq
MIRT1247953	hsa-miR-4478	CLIP-seq
MIRT1247955	hsa-miR-4487	CLIP-seq
MIRT2300303	hsa-miR-451b	CLIP-seq
MIRT1247957	hsa-miR-4649-3p	CLIP-seq
MIRT2300304	hsa-miR-4661-5p	CLIP-seq
MIRT1247963	hsa-miR-4728-5p	CLIP-seq
MIRT1247964	hsa-miR-4747-3p	CLIP-seq
MIRT2300305	hsa-miR-4761-5p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT1247968	hsa-miR-490-3p	CLIP-seq
MIRT2300306	hsa-miR-497	CLIP-seq
MIRT2300307	hsa-miR-520f	CLIP-seq
MIRT1247972	hsa-miR-558	CLIP-seq
MIRT1247974	hsa-miR-658	CLIP-seq
MIRT2300308	hsa-miR-765	CLIP-seq
MIRT2300309	hsa-miR-875-3p	CLIP-seq
MIRT1247978	hsa-miR-921	CLIP-seq
MIRT2300310	hsa-miR-922	CLIP-seq
MIRT2456866	hsa-miR-3136-3p	CLIP-seq
MIRT2456867	hsa-miR-4637	CLIP-seq
MIRT2456868	hsa-miR-548aa	CLIP-seq
MIRT1247933	hsa-miR-3120-5p	CLIP-seq
MIRT1247943	hsa-miR-3664-5p	CLIP-seq
MIRT1247956	hsa-miR-4522	CLIP-seq
MIRT1247966	hsa-miR-4797-5p	CLIP-seq
MIRT1247970	hsa-miR-515-5p	CLIP-seq
MIRT2597058	hsa-miR-759	CLIP-seq
MIRT1247933	hsa-miR-3120-5p	CLIP-seq
MIRT2073177	hsa-miR-3664-3p	CLIP-seq
MIRT1247943	hsa-miR-3664-5p	CLIP-seq
MIRT2300300	hsa-miR-4253	CLIP-seq
MIRT2073178	hsa-miR-4433	CLIP-seq
MIRT1247952	hsa-miR-4459	CLIP-seq
MIRT1247956	hsa-miR-4522	CLIP-seq
MIRT1247961	hsa-miR-4695-5p	CLIP-seq
MIRT2688344	hsa-miR-4761-3p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT1247966	hsa-miR-4797-5p	CLIP-seq
MIRT2073183	hsa-miR-510	CLIP-seq
MIRT2073184	hsa-miR-512-5p	CLIP-seq
MIRT1247970	hsa-miR-515-5p	CLIP-seq
MIRT2597058	hsa-miR-759	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA	21873635
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS
GO:0005515	Function	Protein binding	IPI	16189514, 16763556, 18923427, 19060904, 21516116, 25416956, 30659753, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	TAS
GO:0006260	Process	DNA replication	IEA
GO:0006281	Process	DNA repair	TAS	10458907
GO:0016607	Component	Nuclear speck	IDA
GO:0019985	Process	Translesion synthesis	IBA	21873635
GO:0019985	Process	Translesion synthesis	TAS
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA
GO:0042276	Process	Error-prone translesion synthesis	TAS
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
605252	9182	ENSG00000101751

Protein

UniProt ID

Q9UNA4

Protein name

DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)

Protein function

Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:1

PDB

1T3N , 1ZET , 2ALZ , 2DPI , 2DPJ , 2FLL , 2FLN , 2FLP , 2KHU , 2KHW , 2KTF , 2L0F , 2L0G , 2MBB , 3EPG , 3EPI , 3G6V , 3G6X , 3G6Y , 3GV5 , 3GV7 , 3GV8 , 3H40 , 3H4B , 3H4D , 3NGD , 3OSN , 3Q8P , 3Q8Q , 3Q8R , 3Q8S , 4EBC , 4EBD , 4EBE , 4EYH , 4EYI , 4FS1 , 4FS2 , 5KT2 , 5KT3 , 5KT4 , 5KT5 , 5KT6 , 5KT7 , 5ULW , 5ULX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00817	IMS	58 → 236	impB/mucB/samB family	Family
PF11799	IMS_C	320 → 446	impB/mucB/samB family C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in testis. {ECO:0000269|PubMed:10458907, ECO:0000269|PubMed:11387224}.

Sequence

MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDL
DCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVN
GEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSG
HVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKP
NQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQD
GRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMV
NVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPK
DKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQ
EEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPC
EPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFP
NLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAV
QKELLAEWKRAGSDFHIGHK

Sequence length

740

Interactions

View interactions

	KEGG		Reactome
	Fanconi anemia pathway		Translesion synthesis by POLI Termination of translesion DNA synthesis

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	23143594, 25903422, 25574825

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma, Childhood asthma		30929738	ClinVar, GWAS
Eczema	Eczema			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma			GWAS

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	37079368
Breast Neoplasms	Associate	27485818, 30829610
Carcinogenesis	Associate	36526675
Clear cell metastatic renal cell carcinoma	Associate	39237917
Developmental Disabilities	Associate	34887565
Esophageal Neoplasms	Associate	22509890, 26097541
Esophageal Squamous Cell Carcinoma	Associate	22509890, 28905458
Fanconi Anemia	Associate	33376220
Glioblastoma	Associate	17499043
Leiomyosarcoma	Associate	35201535
Neoplasm Metastasis	Associate	28905458
Neoplasms	Associate	22509890, 24113281, 25277384, 29669917, 31382053, 34887565, 35201535, 35955705, 36526675, 37167337, 39237917
Neoplasms Squamous Cell	Associate	26097541
Neurodegenerative Diseases	Associate	28777933
Oligospermia	Associate	31002754
Pancreatic Neoplasms	Associate	35955705
Urinary Bladder Neoplasms	Associate	23922701

POLI (DNA polymerase iota)