Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11193
Gene name Gene Name - the full gene name approved by the HGNC.
WW domain binding protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WBP4
Synonyms (NCBI Gene) Gene synonyms aliases
FBP21, NEDHFDB
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDHFDB
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q14.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050577 hsa-miR-20a-5p CLASH 23622248
MIRT405627 hsa-miR-19b-3p PAR-CLIP 20371350
MIRT405626 hsa-miR-19a-3p PAR-CLIP 20371350
MIRT405636 hsa-miR-548n PAR-CLIP 20371350
MIRT405630 hsa-miR-548a-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000398 Process MRNA splicing, via spliceosome IDA 28781166
GO:0000398 Process MRNA splicing, via spliceosome TAS
GO:0003723 Function RNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 17500595, 28838205
GO:0005634 Component Nucleus IDA 28781166
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604981 12739 ENSG00000120688
Protein
UniProt ID O75554
Protein name WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4)
Protein function Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:195
PDB 2DK1 , 2JXW , 5O9Z , 6AHD , 7OS1 , 8H6K , 8H6L , 8Q7N , 8QO9 , 8QPE , 8QZS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06220 zf-U1 8 44 U1 zinc finger Domain
PF00397 WW 124 153 WW domain Domain
PF00397 WW 165 194 WW domain Domain
Sequence
MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRISEIKQKSLDKAKEEEK
ASKEFAAMEAAALKAYQEDLKRLGLESEILEPSITPVTSTIPPTSTSNQQKEKKEKKKRK
KDPSKGRWVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTY
YYNTETGESRWEKP
DDFIPHTSDLPSSKVNENSLGTLDESKSSDSHSDSDGEQEAEEGGV
STETEKPKIKFKEKNKNSDGGSDPETQKEKSIQKQNSLGSNEEKSKTLKKSNPYGEWQEI
KQEVESHEEVDLELPSTENEYVSTSEADGGGEPKVVFKEKTVTSLGVMADGVAPVFKKRR
TENGKSRNLRQRGDDQ
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    mRNA Splicing - Major Pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Developmental Disabilities Associate 37963460
Intellectual Disability Associate 37963460