Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11185
Gene name	Indolethylamine N-methyltransferase
Gene symbol	INMT
Synonyms (NCBI Gene)	TEMT
Chromosome	7
Chromosome location	7p14.3
Summary	N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcr

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Show/Hide all (263)

miRTarBase ID	miRNA	Experiments	Reference
MIRT697177	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT697178	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT697175	hsa-miR-4733-3p	HITS-CLIP	23313552
MIRT697176	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT697174	hsa-miR-4459	HITS-CLIP	23313552
MIRT697173	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT697172	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT697171	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT697170	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT697169	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT697168	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT697167	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT697166	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT697165	hsa-miR-6745	HITS-CLIP	23313552
MIRT697164	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT697163	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT697162	hsa-miR-1293	HITS-CLIP	23313552
MIRT697161	hsa-miR-4483	HITS-CLIP	23313552
MIRT697160	hsa-miR-3165	HITS-CLIP	23313552
MIRT697159	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT697158	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT697157	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT697156	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT697155	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT697154	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT697153	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT697152	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT697151	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT697150	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT697149	hsa-miR-3689c	HITS-CLIP	23313552
MIRT697148	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT697147	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT697146	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT697145	hsa-miR-3122	HITS-CLIP	23313552
MIRT697144	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT697143	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT697142	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT673977	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT673976	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT673975	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT673974	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT673973	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT673972	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT673971	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT673970	hsa-miR-4284	HITS-CLIP	23824327
MIRT673969	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673968	hsa-miR-3652	HITS-CLIP	23824327
MIRT673967	hsa-miR-4430	HITS-CLIP	23824327
MIRT673966	hsa-miR-4505	HITS-CLIP	23824327
MIRT673965	hsa-miR-5787	HITS-CLIP	23824327
MIRT673964	hsa-miR-4466	HITS-CLIP	23824327
MIRT673963	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT673962	hsa-miR-7977	HITS-CLIP	23824327
MIRT673961	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT673960	hsa-miR-6741-5p	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT650951	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT650950	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT650949	hsa-miR-4486	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650945	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT697177	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT697178	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT697175	hsa-miR-4733-3p	HITS-CLIP	23313552
MIRT697176	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT697174	hsa-miR-4459	HITS-CLIP	23313552
MIRT697173	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT697172	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT697171	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT697170	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT697169	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT697168	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT697167	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT697166	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT697165	hsa-miR-6745	HITS-CLIP	23313552
MIRT697164	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT697163	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT697162	hsa-miR-1293	HITS-CLIP	23313552
MIRT697161	hsa-miR-4483	HITS-CLIP	23313552
MIRT697160	hsa-miR-3165	HITS-CLIP	23313552
MIRT697159	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT697158	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT697157	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT697156	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT697155	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT697154	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT697153	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT697152	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT697151	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT697150	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT697149	hsa-miR-3689c	HITS-CLIP	23313552
MIRT697148	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT697147	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT697146	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT697145	hsa-miR-3122	HITS-CLIP	23313552
MIRT697144	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT697143	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT697142	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT673977	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT673976	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT673975	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT673974	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT673973	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT673972	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT673971	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT673970	hsa-miR-4284	HITS-CLIP	23824327
MIRT673969	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673968	hsa-miR-3652	HITS-CLIP	23824327
MIRT673967	hsa-miR-4430	HITS-CLIP	23824327
MIRT673966	hsa-miR-4505	HITS-CLIP	23824327
MIRT673965	hsa-miR-5787	HITS-CLIP	23824327
MIRT673964	hsa-miR-4466	HITS-CLIP	23824327
MIRT673963	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT673962	hsa-miR-7977	HITS-CLIP	23824327
MIRT673961	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT673960	hsa-miR-6741-5p	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT650951	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT650950	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT650949	hsa-miR-4486	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650945	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT1066688	hsa-miR-1286	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT1066691	hsa-miR-24	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT1066693	hsa-miR-3679-3p	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT1066695	hsa-miR-4275	CLIP-seq
MIRT1066696	hsa-miR-4327	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066698	hsa-miR-4436a	CLIP-seq
MIRT1066699	hsa-miR-4436b-5p	CLIP-seq
MIRT1066700	hsa-miR-4455	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT1066702	hsa-miR-4524	CLIP-seq
MIRT1066703	hsa-miR-4649-3p	CLIP-seq
MIRT1066704	hsa-miR-4661-3p	CLIP-seq
MIRT1066705	hsa-miR-4690-5p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT1066707	hsa-miR-4724-3p	CLIP-seq
MIRT1066708	hsa-miR-4773	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT1066710	hsa-miR-483-3p	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT1066712	hsa-miR-543	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq
MIRT1066715	hsa-miR-609	CLIP-seq
MIRT1066716	hsa-miR-675	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT1066693	hsa-miR-3679-3p	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT1066703	hsa-miR-4649-3p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT1066708	hsa-miR-4773	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT1066712	hsa-miR-543	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT1066696	hsa-miR-4327	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066691	hsa-miR-24	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT2015997	hsa-miR-4252	CLIP-seq
MIRT1066696	hsa-miR-4327	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT1066703	hsa-miR-4649-3p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT2015998	hsa-miR-4793-3p	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT2015999	hsa-miR-508-5p	CLIP-seq
MIRT2016000	hsa-miR-766	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT1066693	hsa-miR-3679-3p	CLIP-seq
MIRT2015997	hsa-miR-4252	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT1066708	hsa-miR-4773	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT1066712	hsa-miR-543	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT2248485	hsa-miR-661	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT2451869	hsa-miR-3675-3p	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT2451870	hsa-miR-4684-5p	CLIP-seq
MIRT2451871	hsa-miR-548c-3p	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT2552007	hsa-miR-1273	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT2552008	hsa-miR-2355-5p	CLIP-seq
MIRT2552009	hsa-miR-3613-3p	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT2552010	hsa-miR-3671	CLIP-seq
MIRT2451869	hsa-miR-3675-3p	CLIP-seq
MIRT2552011	hsa-miR-371-5p	CLIP-seq
MIRT2552012	hsa-miR-371b-5p	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT2015997	hsa-miR-4252	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT2552013	hsa-miR-4649-5p	CLIP-seq
MIRT2451870	hsa-miR-4684-5p	CLIP-seq
MIRT2552014	hsa-miR-4693-3p	CLIP-seq
MIRT2552015	hsa-miR-4712-3p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT2015998	hsa-miR-4793-3p	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT2015999	hsa-miR-508-5p	CLIP-seq
MIRT2451871	hsa-miR-548c-3p	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq
MIRT2248485	hsa-miR-661	CLIP-seq
MIRT2016000	hsa-miR-766	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT2451869	hsa-miR-3675-3p	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT2682840	hsa-miR-4433	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT2451870	hsa-miR-4684-5p	CLIP-seq
MIRT2682841	hsa-miR-4786-5p	CLIP-seq
MIRT2682842	hsa-miR-4793-5p	CLIP-seq
MIRT2682843	hsa-miR-4794	CLIP-seq
MIRT2451871	hsa-miR-548c-3p	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004790	Function	Thioether S-methyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	10552930
GO:0005829	Component	Cytosol	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008170	Function	N-methyltransferase activity	IBA
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0009308	Process	Amine metabolic process	IDA	10552930
GO:0009636	Process	Response to toxic substance	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030748	Function	Amine N-methyltransferase activity	IBA
GO:0030748	Function	Amine N-methyltransferase activity	IDA	10552930
GO:0030748	Function	Amine N-methyltransferase activity	IEA
GO:0032259	Process	Methylation	IDA	10552930
GO:0032259	Process	Methylation	IEA

MIM	HGNC	e!Ensembl
604854	6069	ENSG00000241644

O95050

Protein name

Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT)

Protein function

Functions as a thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine,

PDB

2A14

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01234	NNMT_PNMT_TEMT	1 → 259	NNMT/PNMT/TEMT family	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very l

Sequence

MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI
DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ
SYSVTNAANNGVCFIVARKKPGP

Sequence length

263

Interactions

View interactions

	KEGG
	Tryptophan metabolism Selenocompound metabolism Metabolic pathways

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Prostate cancer	Uncertain significance	rs193920790	RCV000149186

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Atrial Fibrillation	Associate	33062700
Carcinoma Hepatocellular	Inhibit	37202783
Lung Neoplasms	Associate	30177858
Nephrolithiasis	Associate	22396660
Obesity	Associate	24696292
Pregnancy in Diabetics	Associate	24696292
Prostatic Neoplasms	Associate	22075945

INMT (indolethylamine N-methyltransferase)