Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11170
Gene name Gene Name - the full gene name approved by the HGNC.	Family with sequence similarity 107 member A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FAM107A
Synonyms (NCBI Gene) Gene synonyms aliases	DRR1, TU3A
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p14.3-p14.2

Show/Hide all(216)

miRTarBase ID	miRNA	Experiments	Reference
MIRT710276	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710275	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT710274	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT710273	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710272	hsa-miR-1913	HITS-CLIP	19536157
MIRT710271	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT710270	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT710269	hsa-miR-7976	HITS-CLIP	19536157
MIRT710268	hsa-miR-3173-5p	HITS-CLIP	19536157
MIRT710267	hsa-miR-6799-3p	HITS-CLIP	19536157
MIRT710266	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT710265	hsa-miR-938	HITS-CLIP	19536157
MIRT710264	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT710263	hsa-miR-346	HITS-CLIP	19536157
MIRT710262	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT710261	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT710260	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT710259	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT710258	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT710276	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710275	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT710274	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT710273	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710272	hsa-miR-1913	HITS-CLIP	19536157
MIRT710271	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT710270	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT710269	hsa-miR-7976	HITS-CLIP	19536157
MIRT710268	hsa-miR-3173-5p	HITS-CLIP	19536157
MIRT710267	hsa-miR-6799-3p	HITS-CLIP	19536157
MIRT710266	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT710265	hsa-miR-938	HITS-CLIP	19536157
MIRT710264	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT710263	hsa-miR-346	HITS-CLIP	19536157
MIRT710262	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT710261	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT710260	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT710259	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT710258	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT710276	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710275	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT710274	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT710273	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710272	hsa-miR-1913	HITS-CLIP	19536157
MIRT710271	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT710270	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT710269	hsa-miR-7976	HITS-CLIP	19536157
MIRT710268	hsa-miR-3173-5p	HITS-CLIP	19536157
MIRT710267	hsa-miR-6799-3p	HITS-CLIP	19536157
MIRT710266	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT710265	hsa-miR-938	HITS-CLIP	19536157
MIRT710264	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT710263	hsa-miR-346	HITS-CLIP	19536157
MIRT710262	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT710261	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT710260	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT710259	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT710258	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT626002	hsa-miR-4282	HITS-CLIP	23824327
MIRT663270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT616583	hsa-miR-634	HITS-CLIP	23824327
MIRT616581	hsa-miR-1226-3p	HITS-CLIP	23824327
MIRT616580	hsa-miR-4530	HITS-CLIP	23824327
MIRT616579	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626002	hsa-miR-4282	HITS-CLIP	23824327
MIRT616583	hsa-miR-634	HITS-CLIP	23824327
MIRT616582	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT616581	hsa-miR-1226-3p	HITS-CLIP	23824327
MIRT616580	hsa-miR-4530	HITS-CLIP	23824327
MIRT616579	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT663270	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT663270	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT663270	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT663270	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT626002	hsa-miR-4282	HITS-CLIP	27418678
MIRT626002	hsa-miR-4282	HITS-CLIP	27418678
MIRT626002	hsa-miR-4282	HITS-CLIP	27418678
MIRT710276	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710275	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT710274	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT710273	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710272	hsa-miR-1913	HITS-CLIP	19536157
MIRT710271	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT710270	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT710269	hsa-miR-7976	HITS-CLIP	19536157
MIRT710268	hsa-miR-3173-5p	HITS-CLIP	19536157
MIRT710267	hsa-miR-6799-3p	HITS-CLIP	19536157
MIRT710266	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT710265	hsa-miR-938	HITS-CLIP	19536157
MIRT710264	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT710263	hsa-miR-346	HITS-CLIP	19536157
MIRT710262	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT710261	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT710260	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT710259	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT710258	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT710276	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710275	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT710274	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT710273	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710272	hsa-miR-1913	HITS-CLIP	19536157
MIRT710271	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT710270	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT710269	hsa-miR-7976	HITS-CLIP	19536157
MIRT710268	hsa-miR-3173-5p	HITS-CLIP	19536157
MIRT710267	hsa-miR-6799-3p	HITS-CLIP	19536157
MIRT710266	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT710265	hsa-miR-938	HITS-CLIP	19536157
MIRT710264	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT710263	hsa-miR-346	HITS-CLIP	19536157
MIRT710262	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT710261	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT710260	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT710259	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT710258	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT710276	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710275	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT710274	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT710273	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710272	hsa-miR-1913	HITS-CLIP	19536157
MIRT710271	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT710270	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT710269	hsa-miR-7976	HITS-CLIP	19536157
MIRT710268	hsa-miR-3173-5p	HITS-CLIP	19536157
MIRT710267	hsa-miR-6799-3p	HITS-CLIP	19536157
MIRT710266	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT710265	hsa-miR-938	HITS-CLIP	19536157
MIRT710264	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT710263	hsa-miR-346	HITS-CLIP	19536157
MIRT710262	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT710261	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT710260	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT710259	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT710258	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT626002	hsa-miR-4282	HITS-CLIP	23824327
MIRT663270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT616583	hsa-miR-634	HITS-CLIP	23824327
MIRT616581	hsa-miR-1226-3p	HITS-CLIP	23824327
MIRT616580	hsa-miR-4530	HITS-CLIP	23824327
MIRT616579	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626002	hsa-miR-4282	HITS-CLIP	23824327
MIRT616583	hsa-miR-634	HITS-CLIP	23824327
MIRT616582	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT616581	hsa-miR-1226-3p	HITS-CLIP	23824327
MIRT616580	hsa-miR-4530	HITS-CLIP	23824327
MIRT616579	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT976692	hsa-miR-1262	CLIP-seq
MIRT976693	hsa-miR-1827	CLIP-seq
MIRT976694	hsa-miR-3127-5p	CLIP-seq
MIRT976695	hsa-miR-3167	CLIP-seq
MIRT976696	hsa-miR-4420	CLIP-seq
MIRT976697	hsa-miR-4452	CLIP-seq
MIRT976698	hsa-miR-4476	CLIP-seq
MIRT976699	hsa-miR-4506	CLIP-seq
MIRT976700	hsa-miR-4650-5p	CLIP-seq
MIRT976701	hsa-miR-4653-3p	CLIP-seq
MIRT976702	hsa-miR-4668-5p	CLIP-seq
MIRT976703	hsa-miR-4701-3p	CLIP-seq
MIRT976704	hsa-miR-4715-5p	CLIP-seq
MIRT976705	hsa-miR-4786-3p	CLIP-seq
MIRT976706	hsa-miR-571	CLIP-seq
MIRT976707	hsa-miR-629	CLIP-seq
MIRT976708	hsa-miR-651	CLIP-seq
MIRT976709	hsa-miR-671-5p	CLIP-seq
MIRT976710	hsa-miR-876-5p	CLIP-seq
MIRT976711	hsa-miR-1252	CLIP-seq
MIRT976692	hsa-miR-1262	CLIP-seq
MIRT976712	hsa-miR-3202	CLIP-seq
MIRT976696	hsa-miR-4420	CLIP-seq
MIRT976697	hsa-miR-4452	CLIP-seq
MIRT976699	hsa-miR-4506	CLIP-seq
MIRT976713	hsa-miR-4533	CLIP-seq
MIRT976701	hsa-miR-4653-3p	CLIP-seq
MIRT976703	hsa-miR-4701-3p	CLIP-seq
MIRT976706	hsa-miR-571	CLIP-seq
MIRT976714	hsa-miR-636	CLIP-seq
MIRT1548475	hsa-miR-432	CLIP-seq
MIRT1921778	hsa-miR-1226	CLIP-seq
MIRT1921779	hsa-miR-1228	CLIP-seq
MIRT1921778	hsa-miR-1226	CLIP-seq
MIRT1921779	hsa-miR-1228	CLIP-seq
MIRT1989451	hsa-miR-1236	CLIP-seq
MIRT1989452	hsa-miR-23a	CLIP-seq
MIRT1989453	hsa-miR-23b	CLIP-seq
MIRT1989454	hsa-miR-23c	CLIP-seq
MIRT1989455	hsa-miR-326	CLIP-seq
MIRT1989456	hsa-miR-330-5p	CLIP-seq
MIRT1989457	hsa-miR-342-5p	CLIP-seq
MIRT1989458	hsa-miR-412	CLIP-seq
MIRT1989459	hsa-miR-4539	CLIP-seq
MIRT1989460	hsa-miR-4651	CLIP-seq
MIRT1989461	hsa-miR-4664-5p	CLIP-seq
MIRT1989462	hsa-miR-4667-5p	CLIP-seq
MIRT1989463	hsa-miR-4700-5p	CLIP-seq
MIRT1989464	hsa-miR-4717-3p	CLIP-seq
MIRT1989465	hsa-miR-4753-3p	CLIP-seq
MIRT1989466	hsa-miR-608	CLIP-seq
MIRT1989467	hsa-miR-617	CLIP-seq
MIRT1989468	hsa-miR-637	CLIP-seq
MIRT1989469	hsa-miR-642b	CLIP-seq
MIRT1989470	hsa-miR-654-3p	CLIP-seq
MIRT1989471	hsa-miR-942	CLIP-seq
MIRT976692	hsa-miR-1262	CLIP-seq
MIRT2223796	hsa-miR-2964a-3p	CLIP-seq
MIRT976696	hsa-miR-4420	CLIP-seq
MIRT976697	hsa-miR-4452	CLIP-seq
MIRT976699	hsa-miR-4506	CLIP-seq
MIRT976701	hsa-miR-4653-3p	CLIP-seq
MIRT976703	hsa-miR-4701-3p	CLIP-seq
MIRT976706	hsa-miR-571	CLIP-seq
MIRT2387668	hsa-miR-3074-3p	CLIP-seq
MIRT2387669	hsa-miR-4690-3p	CLIP-seq
MIRT2680466	hsa-miR-329	CLIP-seq
MIRT2680467	hsa-miR-362-3p	CLIP-seq
MIRT2680468	hsa-miR-3941	CLIP-seq
MIRT2680469	hsa-miR-4789-5p	CLIP-seq
MIRT2680470	hsa-miR-603	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	IDA	10564580
GO:0001725	Component	Stress fiber	IBA	21873635
GO:0001725	Component	Stress fiber	IDA	20543869
GO:0003674	Function	Molecular_function	ND
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	20543869, 28604741
GO:0005634	Component	Nucleus	IDA	10564580, 20543869, 28604741
GO:0005737	Component	Cytoplasm	IDA	28604741
GO:0005925	Component	Focal adhesion	IDA	20543869
GO:0007049	Process	Cell cycle	IEA
GO:0015629	Component	Actin cytoskeleton	IDA	28604741
GO:0015629	Component	Actin cytoskeleton	ISS
GO:0016607	Component	Nuclear speck	IDA
GO:0030041	Process	Actin filament polymerization	IBA	21873635
GO:0030041	Process	Actin filament polymerization	ISS
GO:0030335	Process	Positive regulation of cell migration	IMP	20543869
GO:0031398	Process	Positive regulation of protein ubiquitination	IMP	28604741
GO:0031647	Process	Regulation of protein stability	IMP	28604741
GO:0031669	Process	Cellular response to nutrient levels	ISS
GO:0032587	Component	Ruffle membrane	IDA	20543869
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	20543869
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043005	Component	Neuron projection	ISS
GO:0045202	Component	Synapse	IBA	21873635
GO:0045202	Component	Synapse	ISS
GO:0050890	Process	Cognition	ISS
GO:0051017	Process	Actin filament bundle assembly	IBA	21873635
GO:0051017	Process	Actin filament bundle assembly	ISS
GO:0051895	Process	Negative regulation of focal adhesion assembly	IMP	20543869
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IMP	20543869
GO:0071385	Process	Cellular response to glucocorticoid stimulus	ISS
GO:1900272	Process	Negative regulation of long-term synaptic potentiation	ISS
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IMP	28604741

MIM	HGNC	e!Ensembl
608295	30827	ENSG00000168309

Protein

UniProt ID

O95990

Protein name

Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A)

Protein function

Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06625	DUF1151	23 → 133	Protein of unknown function (DUF1151)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed (PubMed:10564580). Expressed in neurons (PubMed:20543869). Expressed in malignant glial tumors (PubMed:20543869). Expression is reduced or absent in a number of cancer cell lines (PubMed:10564580). {ECO:0000269|PubMed:

Sequence

MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLG
VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH
APEFIKVRENLRRIATLTSEEREL

Sequence length

144

Interactions

View interactions

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Autoimmune diseases	Autoimmune Diseases	rs869025224	21383967
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499 View all (13 more)	16865689
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	22190364
Ovarian cancer	Malignant neoplasm of ovary	rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828 View all (31 more)
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	20453842, 23143596, 22446963

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	18191109
Carcinoma Renal Cell	Associate	25230976
Carcinoma Squamous Cell	Associate	33907270
Carcinoma Squamous Cell	Inhibit	38188687
Inflammation	Associate	35528167
Laryngeal Neoplasms	Inhibit	28710449
Leukemia Myeloid Acute	Associate	35528167
Neoplasms	Inhibit	28710449
Prostatic Neoplasms	Associate	36124532
Schizophrenia	Associate	18191109
Squamous Cell Carcinoma of Head and Neck	Inhibit	28710449
Stomach Neoplasms	Associate	34686626
Urinary Bladder Neoplasms	Inhibit	33753712

FAM107A (family with sequence similarity 107 member A)