PTP4A3 (protein tyrosine phosphatase 4A3)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11156
Gene name Gene Name - the full gene name approved by the HGNC.
Protein tyrosine phosphatase 4A3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTP4A3
Synonyms (NCBI Gene) Gene synonyms aliases
PRL-3, PRL-R, PRL3
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(27)
miRTarBase ID miRNA Experiments Reference
MIRT004166 hsa-miR-192-5p Microarray 16822819
MIRT053486 hsa-miR-495-3p qRT-PCR, Western blot 22469786
MIRT053487 hsa-miR-551a qRT-PCR, Western blot 22469786
MIRT1274136 hsa-miR-1915 CLIP-seq
MIRT1274137 hsa-miR-3184 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0004725 Function Protein tyrosine phosphatase activity IBA 21873635
GO:0004727 Function Prenylated protein tyrosine phosphatase activity TAS 9514946
GO:0005515 Function Protein binding IPI 23178297
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IMP 23178297
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606449 9636 ENSG00000184489
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID O75365
Protein name Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Protein function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypert
PDB 1R6H , 1V3A , 2MBC , 5TSR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 30 → 154 Dual specificity phosphatase, catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. {ECO:0000269|PubMed:11355880}.
Sequence
Sequence length 173
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 23555575
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Astrocytoma Astrocytoma GWAS
Show/Hide Text Mining Associations (63)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Mucinous Associate 24696260
Attention Deficit Disorder with Hyperactivity Associate 32238911
Bone Diseases Associate 17934070
Breast Neoplasms Associate 16832410, 20140626, 25547164, 25854368, 26921331, 27452906
Calcinosis Cutis Associate 24030100
Cancer Pain Stimulate 19586538
Carcinogenesis Associate 18268019, 26041460
Carcinoma Adenoid Cystic Associate 26041460
Carcinoma Hepatocellular Associate 23064776, 30418964, 40159482
Carcinoma Intraductal Noninfiltrating Associate 16832410