PTP4A3 (protein tyrosine phosphatase 4A3)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 11156
Gene name Protein tyrosine phosphatase 4A3
Gene symbol PTP4A3
Synonyms (NCBI Gene)
PRL-3PRL-RPRL3
Chromosome 8
Chromosome location 8q24.3
Summary This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice
miRNA miRNA information provided by mirtarbase database.
27
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (27)
miRTarBase ID miRNA Experiments Reference
MIRT004166 hsa-miR-192-5p Microarray 16822819
MIRT053486 hsa-miR-495-3p qRT-PCRWestern blot 22469786
MIRT053487 hsa-miR-551a qRT-PCRWestern blot 22469786
MIRT1274136 hsa-miR-1915 CLIP-seq
MIRT1274137 hsa-miR-3184 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IBA
GO:0004725 Function Protein tyrosine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity TAS 9514946
GO:0005515 Function Protein binding IPI 23178297
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606449 9636 ENSG00000184489
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75365
Protein name Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Protein function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypert
PDB 1R6H , 1V3A , 2MBC , 5TSR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 30 → 154 Dual specificity phosphatase, catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. {ECO:0000269|PubMed:11355880}.
Sequence
Sequence length 173
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLONIC NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (63)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Mucinous Associate 24696260
★★★★★
★☆☆☆☆
Found in Text Mining only
Attention Deficit Disorder with Hyperactivity Associate 32238911
★★★★★
★☆☆☆☆
Found in Text Mining only
Bone Diseases Associate 17934070
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 16832410, 20140626, 25547164, 25854368, 26921331, 27452906
★★★★★
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Associate 24030100
★★★★★
★☆☆☆☆
Found in Text Mining only
Cancer Pain Stimulate 19586538
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 18268019, 26041460
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Adenoid Cystic Associate 26041460
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 23064776, 30418964, 40159482
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Intraductal Noninfiltrating Associate 16832410
★★★★★
★☆☆☆☆
Found in Text Mining only