CHGB (chromogranin B)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1114
Gene name Gene Name - the full gene name approved by the HGNC.
Chromogranin B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CHGB
Synonyms (NCBI Gene) Gene synonyms aliases
SCG1
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(15)
miRTarBase ID miRNA Experiments Reference
MIRT019922 hsa-miR-375 Microarray 20215506
MIRT889846 hsa-miR-1305 CLIP-seq
MIRT889847 hsa-miR-23a CLIP-seq
MIRT889848 hsa-miR-23b CLIP-seq
MIRT889849 hsa-miR-23c CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
REST Unknown 19118055
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity TAS 3608978
GO:0005515 Function Protein binding IPI 20195357, 22582013, 24510904, 24947832, 29513927
GO:0005615 Component Extracellular space IBA 21873635
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0007165 Process Signal transduction IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
118920 1930 ENSG00000089199
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05060
Protein name Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide]
Protein function Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01271 Granin 26 → 677 Granin (chromogranin or secretogranin) Family
Tissue specificity TISSUE SPECIFICITY: Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:37453717). Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:360897
Sequence
Sequence length 677
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia, Chronic schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 17143778, 11959426, 15219467
Show/Hide Text Mining Associations (27)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Inhibit 32366888
Amyotrophic Lateral Sclerosis Associate 20007371
Amyotrophic lateral sclerosis 1 Associate 39336788
Atrial Fibrillation Associate 32682418, 34737791, 35607269, 37960721
Breast Neoplasms Associate 2305832
Carcinoma Squamous Cell Associate 35935970
Cardiovascular Diseases Associate 20359597
Colitis Ulcerative Associate 26530476
Crohn Disease Associate 26530476
Diabetes Mellitus Associate 32171244