Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1111
Gene name	Checkpoint kinase 1
Gene symbol	CHEK1
Synonyms (NCBI Gene)	CHK1OZEMA21
Chromosome	11
Chromosome location	11q24.2
Summary	The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR,

Show/Hide all (3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs772079899	C>G,T	Pathogenic	Stop gained, coding sequence variant, non coding transcript variant, missense variant
rs1314180672	A>G,T	Likely-pathogenic	Splice acceptor variant, intron variant
rs1565374246	CC>-	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained

458

Show/Hide all (458)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000656	hsa-miR-424-5p	Luciferase reporter assay	19956200
MIRT000647	hsa-miR-503-5p	Luciferase reporter assay	19956200
MIRT016503	hsa-miR-193b-3p	Microarray	20304954
MIRT030555	hsa-miR-24-3p	Reporter assay;Western blot;qRT-PCR;Other	19748357
MIRT049764	hsa-miR-92a-3p	CLASH	23622248
MIRT046455	hsa-miR-15b-5p	CLASH	23622248
MIRT044177	hsa-miR-99b-5p	CLASH	23622248
MIRT000656	hsa-miR-424-5p	Luciferase reporter assayWestern blot	22469983
MIRT000656	hsa-miR-424-5p	Luciferase reporter assayWestern blot	22469983
MIRT054859	hsa-miR-497-5p	and 293T cell"	24464213
MIRT265077	hsa-miR-16-5p	Luciferase reporter assayWestern blot	24336073
MIRT438209	hsa-miR-26a-5p	Luciferase reporter assayWestern blot	24336073
MIRT265077	hsa-miR-16-5p	Luciferase reporter assayWestern blot	24336073
MIRT438209	hsa-miR-26a-5p	Luciferase reporter assayWestern blot	24336073
MIRT265087	hsa-miR-6838-5p	HITS-CLIP	23313552
MIRT000656	hsa-miR-424-5p	HITS-CLIP	23313552
MIRT265078	hsa-miR-195-5p	HITS-CLIP	23313552
MIRT046455	hsa-miR-15b-5p	HITS-CLIP	23313552
MIRT265077	hsa-miR-16-5p	HITS-CLIP	23313552
MIRT265076	hsa-miR-15a-5p	HITS-CLIP	23313552
MIRT054859	hsa-miR-497-5p	HITS-CLIP	23313552
MIRT000647	hsa-miR-503-5p	HITS-CLIP	23313552
MIRT704711	hsa-miR-505-3p	HITS-CLIP	23313552
MIRT704710	hsa-miR-6507-5p	HITS-CLIP	23313552
MIRT331938	hsa-miR-513b-3p	HITS-CLIP	23313552
MIRT704709	hsa-miR-646	HITS-CLIP	23313552
MIRT265086	hsa-miR-6074	HITS-CLIP	23313552
MIRT704708	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT265084	hsa-miR-4733-3p	HITS-CLIP	23313552
MIRT265079	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT265083	hsa-miR-4524a-5p	HITS-CLIP	23313552
MIRT265085	hsa-miR-4524b-5p	HITS-CLIP	23313552
MIRT704707	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT129466	hsa-miR-3941	HITS-CLIP	23313552
MIRT129470	hsa-miR-4672	HITS-CLIP	23313552
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT674107	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT674107	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT403557	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT669040	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT669039	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT669038	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT669037	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT669036	hsa-miR-4252	HITS-CLIP	23824327
MIRT669035	hsa-miR-139-3p	HITS-CLIP	23824327
MIRT669034	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT669033	hsa-miR-7703	HITS-CLIP	23824327
MIRT669032	hsa-miR-4531	HITS-CLIP	23824327
MIRT669031	hsa-miR-1270	HITS-CLIP	23824327
MIRT669030	hsa-miR-620	HITS-CLIP	23824327
MIRT669029	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT403557	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT403557	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	24906430
MIRT607512	hsa-miR-4801	HITS-CLIP	24906430
MIRT607511	hsa-miR-8485	HITS-CLIP	24906430
MIRT265076	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT046455	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT265077	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT265078	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT129454	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT129455	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT265078	hsa-miR-195-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26867682
MIRT265078	hsa-miR-195-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26867682
MIRT000647	hsa-miR-503-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26867682
MIRT000647	hsa-miR-503-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26867682
MIRT265076	hsa-miR-15a-5p	Luciferase reporter assayqRT-PCRWestern blot	25594541
MIRT046455	hsa-miR-15b-5p	Luciferase reporter assayqRT-PCRWestern blot	25594541
MIRT265077	hsa-miR-16-5p	Luciferase reporter assayqRT-PCRWestern blot	25594541
MIRT265078	hsa-miR-195-5p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	25840419
MIRT609402	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT609401	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT129466	hsa-miR-3941	HITS-CLIP	27418678
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	27418678
MIRT607512	hsa-miR-4801	HITS-CLIP	27418678
MIRT609400	hsa-miR-603	HITS-CLIP	27418678
MIRT607511	hsa-miR-8485	HITS-CLIP	27418678
MIRT265087	hsa-miR-6838-5p	HITS-CLIP	23313552
MIRT000656	hsa-miR-424-5p	HITS-CLIP	23313552
MIRT265078	hsa-miR-195-5p	HITS-CLIP	23313552
MIRT046455	hsa-miR-15b-5p	HITS-CLIP	23313552
MIRT265077	hsa-miR-16-5p	HITS-CLIP	23313552
MIRT265076	hsa-miR-15a-5p	HITS-CLIP	23313552
MIRT054859	hsa-miR-497-5p	HITS-CLIP	23313552
MIRT000647	hsa-miR-503-5p	HITS-CLIP	23313552
MIRT704711	hsa-miR-505-3p	HITS-CLIP	23313552
MIRT704710	hsa-miR-6507-5p	HITS-CLIP	23313552
MIRT331938	hsa-miR-513b-3p	HITS-CLIP	23313552
MIRT704709	hsa-miR-646	HITS-CLIP	23313552
MIRT265086	hsa-miR-6074	HITS-CLIP	23313552
MIRT704708	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT265084	hsa-miR-4733-3p	HITS-CLIP	23313552
MIRT265079	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT265083	hsa-miR-4524a-5p	HITS-CLIP	23313552
MIRT265085	hsa-miR-4524b-5p	HITS-CLIP	23313552
MIRT704707	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT129466	hsa-miR-3941	HITS-CLIP	23313552
MIRT129470	hsa-miR-4672	HITS-CLIP	23313552
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT674107	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT674107	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT403557	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT669040	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT669039	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT669038	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT669037	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT669036	hsa-miR-4252	HITS-CLIP	23824327
MIRT669035	hsa-miR-139-3p	HITS-CLIP	23824327
MIRT669034	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT669033	hsa-miR-7703	HITS-CLIP	23824327
MIRT669032	hsa-miR-4531	HITS-CLIP	23824327
MIRT669031	hsa-miR-1270	HITS-CLIP	23824327
MIRT669030	hsa-miR-620	HITS-CLIP	23824327
MIRT669029	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT403557	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT403557	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT607513	hsa-miR-4731-3p	HITS-CLIP	23824327
MIRT607512	hsa-miR-4801	HITS-CLIP	23824327
MIRT609402	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609401	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609400	hsa-miR-603	HITS-CLIP	23824327
MIRT129466	hsa-miR-3941	HITS-CLIP	23824327
MIRT129470	hsa-miR-4672	HITS-CLIP	23824327
MIRT129464	hsa-miR-466	HITS-CLIP	23824327
MIRT607511	hsa-miR-8485	HITS-CLIP	23824327
MIRT129473	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT609399	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609398	hsa-miR-6083	HITS-CLIP	23824327
MIRT889682	hsa-miR-3122	CLIP-seq
MIRT889683	hsa-miR-3165	CLIP-seq
MIRT889684	hsa-miR-320e	CLIP-seq
MIRT889685	hsa-miR-3614-5p	CLIP-seq
MIRT889686	hsa-miR-3665	CLIP-seq
MIRT889687	hsa-miR-3689a-3p	CLIP-seq
MIRT889688	hsa-miR-3689c	CLIP-seq
MIRT889689	hsa-miR-3714	CLIP-seq
MIRT889690	hsa-miR-3913-5p	CLIP-seq
MIRT889691	hsa-miR-4668-3p	CLIP-seq
MIRT889692	hsa-miR-4728-5p	CLIP-seq
MIRT889693	hsa-miR-4736	CLIP-seq
MIRT889694	hsa-miR-605	CLIP-seq
MIRT889695	hsa-miR-940	CLIP-seq
MIRT889696	hsa-miR-1226	CLIP-seq
MIRT889697	hsa-miR-1251	CLIP-seq
MIRT889698	hsa-miR-1286	CLIP-seq
MIRT889699	hsa-miR-15a	CLIP-seq
MIRT889700	hsa-miR-15b	CLIP-seq
MIRT889701	hsa-miR-16	CLIP-seq
MIRT889702	hsa-miR-195	CLIP-seq
MIRT889703	hsa-miR-197	CLIP-seq
MIRT889704	hsa-miR-3185	CLIP-seq
MIRT889705	hsa-miR-331-3p	CLIP-seq
MIRT889706	hsa-miR-424	CLIP-seq
MIRT889707	hsa-miR-4436a	CLIP-seq
MIRT889708	hsa-miR-4476	CLIP-seq
MIRT889709	hsa-miR-4524	CLIP-seq
MIRT889710	hsa-miR-4643	CLIP-seq
MIRT889711	hsa-miR-4684-5p	CLIP-seq
MIRT889712	hsa-miR-4722-5p	CLIP-seq
MIRT889713	hsa-miR-4738-3p	CLIP-seq
MIRT889714	hsa-miR-497	CLIP-seq
MIRT889715	hsa-miR-503	CLIP-seq
MIRT889716	hsa-miR-505	CLIP-seq
MIRT889717	hsa-miR-606	CLIP-seq
MIRT889718	hsa-miR-873	CLIP-seq
MIRT889719	hsa-miR-942	CLIP-seq
MIRT889699	hsa-miR-15a	CLIP-seq
MIRT889700	hsa-miR-15b	CLIP-seq
MIRT889701	hsa-miR-16	CLIP-seq
MIRT889702	hsa-miR-195	CLIP-seq
MIRT889706	hsa-miR-424	CLIP-seq
MIRT889709	hsa-miR-4524	CLIP-seq
MIRT889714	hsa-miR-497	CLIP-seq
MIRT889715	hsa-miR-503	CLIP-seq
MIRT889716	hsa-miR-505	CLIP-seq
MIRT889699	hsa-miR-15a	CLIP-seq
MIRT889700	hsa-miR-15b	CLIP-seq
MIRT889701	hsa-miR-16	CLIP-seq
MIRT889702	hsa-miR-195	CLIP-seq
MIRT889706	hsa-miR-424	CLIP-seq
MIRT889709	hsa-miR-4524	CLIP-seq
MIRT889714	hsa-miR-497	CLIP-seq
MIRT889715	hsa-miR-503	CLIP-seq
MIRT889716	hsa-miR-505	CLIP-seq
MIRT889699	hsa-miR-15a	CLIP-seq
MIRT889700	hsa-miR-15b	CLIP-seq
MIRT889701	hsa-miR-16	CLIP-seq
MIRT889702	hsa-miR-195	CLIP-seq
MIRT889706	hsa-miR-424	CLIP-seq
MIRT889709	hsa-miR-4524	CLIP-seq
MIRT889714	hsa-miR-497	CLIP-seq
MIRT889715	hsa-miR-503	CLIP-seq
MIRT889716	hsa-miR-505	CLIP-seq
MIRT889699	hsa-miR-15a	CLIP-seq
MIRT889700	hsa-miR-15b	CLIP-seq
MIRT889701	hsa-miR-16	CLIP-seq
MIRT889702	hsa-miR-195	CLIP-seq
MIRT889706	hsa-miR-424	CLIP-seq
MIRT889709	hsa-miR-4524	CLIP-seq
MIRT889714	hsa-miR-497	CLIP-seq
MIRT889715	hsa-miR-503	CLIP-seq
MIRT889716	hsa-miR-505	CLIP-seq
MIRT889696	hsa-miR-1226	CLIP-seq
MIRT889698	hsa-miR-1286	CLIP-seq
MIRT889699	hsa-miR-15a	CLIP-seq
MIRT889700	hsa-miR-15b	CLIP-seq
MIRT889701	hsa-miR-16	CLIP-seq
MIRT889702	hsa-miR-195	CLIP-seq
MIRT889703	hsa-miR-197	CLIP-seq
MIRT2199997	hsa-miR-2355-5p	CLIP-seq
MIRT889706	hsa-miR-424	CLIP-seq
MIRT889707	hsa-miR-4436a	CLIP-seq
MIRT889709	hsa-miR-4524	CLIP-seq
MIRT2199998	hsa-miR-4537	CLIP-seq
MIRT889712	hsa-miR-4722-5p	CLIP-seq
MIRT889714	hsa-miR-497	CLIP-seq
MIRT889715	hsa-miR-503	CLIP-seq
MIRT889717	hsa-miR-606	CLIP-seq
MIRT889718	hsa-miR-873	CLIP-seq
MIRT2386011	hsa-miR-1827	CLIP-seq
MIRT889682	hsa-miR-3122	CLIP-seq
MIRT889683	hsa-miR-3165	CLIP-seq
MIRT2386012	hsa-miR-3202	CLIP-seq
MIRT889685	hsa-miR-3614-5p	CLIP-seq
MIRT889686	hsa-miR-3665	CLIP-seq
MIRT889687	hsa-miR-3689a-3p	CLIP-seq
MIRT889688	hsa-miR-3689c	CLIP-seq
MIRT889689	hsa-miR-3714	CLIP-seq
MIRT889690	hsa-miR-3913-5p	CLIP-seq
MIRT2386013	hsa-miR-3929	CLIP-seq
MIRT2386014	hsa-miR-4419b	CLIP-seq
MIRT2386015	hsa-miR-4478	CLIP-seq
MIRT2386016	hsa-miR-4533	CLIP-seq
MIRT2386017	hsa-miR-4649-3p	CLIP-seq
MIRT889712	hsa-miR-4722-5p	CLIP-seq
MIRT889692	hsa-miR-4728-5p	CLIP-seq
MIRT889693	hsa-miR-4736	CLIP-seq
MIRT2386018	hsa-miR-4768-3p	CLIP-seq
MIRT2386019	hsa-miR-890	CLIP-seq
MIRT889695	hsa-miR-940	CLIP-seq
MIRT889716	hsa-miR-505	CLIP-seq
MIRT2386011	hsa-miR-1827	CLIP-seq
MIRT889712	hsa-miR-4722-5p	CLIP-seq
MIRT2386018	hsa-miR-4768-3p	CLIP-seq
MIRT2446999	hsa-miR-665	CLIP-seq
MIRT889695	hsa-miR-940	CLIP-seq
MIRT889698	hsa-miR-1286	CLIP-seq
MIRT889707	hsa-miR-4436a	CLIP-seq
MIRT889712	hsa-miR-4722-5p	CLIP-seq
MIRT889698	hsa-miR-1286	CLIP-seq
MIRT889707	hsa-miR-4436a	CLIP-seq
MIRT889712	hsa-miR-4722-5p	CLIP-seq

Show/Hide all (5)

Transcription factor	Regulation	Reference
BCL6	Repression	18346918
E2F1	Unknown	18660752
MYC	Activation	23269272
TP53	Repression	15016801
TP53	Unknown	11152453

Show/Hide all (77)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000077	Process	DNA damage checkpoint signaling	IDA	16963448
GO:0000077	Process	DNA damage checkpoint signaling	IEA
GO:0000077	Process	DNA damage checkpoint signaling	IEA
GO:0000077	Process	DNA damage checkpoint signaling	IMP	19716789
GO:0000086	Process	G2/M transition of mitotic cell cycle	IDA	2188730
GO:0000086	Process	G2/M transition of mitotic cell cycle	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0000781	Component	Chromosome, telomeric region	IDA	15149599
GO:0000785	Component	Chromatin	IEA
GO:0000785	Component	Chromatin	ISS
GO:0000794	Component	Condensed nuclear chromosome	IDA	9382850
GO:0001833	Process	Inner cell mass cell proliferation	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	IMP	22024163
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9278511, 16963448
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	11836499, 15665856, 15798197, 16330544, 16511572, 16963448, 17380128, 19223857, 19330022, 19716789, 20639859, 22505024, 22939624, 25249323, 28514442, 33961781, 35271311, 35512704, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA	15311285, 20932473, 26296656
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005657	Component	Replication fork	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IDA	26296656
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	15311285
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006260	Process	DNA replication	TAS
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IMP	19716789
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006338	Process	Chromatin remodeling	ISS
GO:0006468	Process	Protein phosphorylation	IDA	33108758
GO:0006915	Process	Apoptotic process	IDA	23028632
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	20932473
GO:0006974	Process	DNA damage response	ISS
GO:0006997	Process	Nucleus organization	IEA
GO:0006998	Process	Nuclear envelope organization	IDA	2188730
GO:0007077	Process	Mitotic nuclear membrane disassembly	IDA	2188730
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IBA
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IMP	20932473
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010569	Process	Regulation of double-strand break repair via homologous recombination	IDA	15665856
GO:0010971	Process	Positive regulation of G2/M transition of mitotic cell cycle	IDA	20360007
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018107	Process	Peptidyl-threonine phosphorylation	IDA	15665856
GO:0019904	Function	Protein domain specific binding	IPI	26296656
GO:0032991	Component	Protein-containing complex	IDA	26296656
GO:0035402	Function	Histone H3T11 kinase activity	IBA
GO:0035402	Function	Histone H3T11 kinase activity	IDA	18243098
GO:0035402	Function	Histone H3T11 kinase activity	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042770	Process	Signal transduction in response to DNA damage	IDA	16963448
GO:0042770	Process	Signal transduction in response to DNA damage	IEA
GO:0044818	Process	Mitotic G2/M transition checkpoint	IDA	9278511
GO:0044818	Process	Mitotic G2/M transition checkpoint	IMP	33108758
GO:0045787	Process	Positive regulation of cell cycle	IDA	26296656
GO:0045814	Process	Negative regulation of gene expression, epigenetic	IEA
GO:0045814	Process	Negative regulation of gene expression, epigenetic	ISS
GO:0045839	Process	Negative regulation of mitotic nuclear division	IDA	15311285
GO:0046602	Process	Regulation of mitotic centrosome separation	IDA	15311285
GO:0070317	Process	Negative regulation of G0 to G1 transition	TAS
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:0090399	Process	Replicative senescence	NAS	15149599
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1901988	Process	Negative regulation of cell cycle phase transition	IEA
GO:1902742	Process	Apoptotic process involved in development	IEA

MIM	HGNC	e!Ensembl
603078	1925	ENSG00000149554

O14757

Protein name

Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)

Protein function

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:145

PDB

1IA8 , 1NVQ , 1NVR , 1NVS , 1ZLT , 1ZYS , 2AYP , 2BR1 , 2BRB , 2BRG , 2BRH , 2BRM , 2BRN , 2BRO , 2C3J , 2C3K , 2C3L , 2CGU , 2CGV , 2CGW , 2CGX , 2E9N , 2E9O , 2E9P , 2E9U , 2E9V , 2GDO , 2GHG , 2HOG , 2HXL , 2HXQ , 2HY0 , 2QHM , 2QHN , 2R0U , 2WMQ , 2WMR , 2WMS , 2WMT , 2WMU , 2WMV , 2WMW , 2WMX , 2X8D , 2X8E , 2X8I , 2XEY , 2XEZ , 2XF0 , 2YDI , 2YDJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	9 → 265	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon. {ECO:0000269|PubMed:9278511, ECO:0000269|PubMed:9382850}.

Sequence

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

Sequence length

476

Interactions

View interactions

	KEGG		Reactome
	Cell cycle p53 signaling pathway Cellular senescence Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection Viral carcinogenesis		Signaling by SCF-KIT Activation of ATR in response to replication stress Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Transcriptional Regulation by E2F6

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Male infertility due to gonadal dysgenesis or sperm disorder	Likely pathogenic	rs199535573	RCV003991594
Oocyte/zygote/embryo maturation arrest 21	Pathogenic	rs2136029824, rs2498414424, rs2498414471, rs2498413938	RCV003444093 RCV003444094 RCV003444095 RCV003444096

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
CHEK1-related disorder	Uncertain significance; Likely benign; Benign	rs767367809, rs3731410, rs775245290, rs1940569859, rs2498291410, rs2498240790, rs1057440910, rs747973479, rs779165764, rs112837504, rs757716680, rs2498238508, rs556405813, rs116191495, rs565780672 View all (11 more)	RCV003399730 RCV003417065 RCV003392754 RCV003391664 RCV003394472 RCV003397289 RCV003917278 RCV003894297 RCV003904303 RCV003897427 RCV003979767 RCV003911466 RCV003909585 RCV003939523 RCV003937075 RCV003961920 RCV003954475 RCV003979042 RCV003982031 RCV003969677 RCV003962311 RCV003972134 RCV004738962 RCV003962656 RCV003983134 RCV003903008
Hereditary cancer-predisposing syndrome	Likely benign; Uncertain significance	rs869312547, rs139144317, rs114579795, rs141004252, rs756054805, rs369248914	RCV000209268 RCV000209594 RCV000209096 RCV000209301 RCV000210167 RCV000708693

Show/Hide Text Mining Associations (137)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Aagenaes syndrome	Associate	29118324
Acquired Immunodeficiency Syndrome	Associate	37468905
Acute Aortic Syndrome	Associate	31721906
Adenocarcinoma Follicular	Associate	27329729
Adenocarcinoma of Lung	Associate	24113549, 29870138, 30607635, 32121037, 32578582, 36714024, 37023702, 37608989, 37762228, 38071755
Adrenocortical Carcinoma	Associate	30413320
Alzheimer Disease	Associate	23550703
Anemia Hemolytic	Associate	21389083
Aneuploidy	Inhibit	23454898
Aniridia	Associate	21423868
Aortic Dissection	Associate	31721906
Arthritis Rheumatoid	Associate	31173250
Ataxia	Associate	18495871
Ataxia Telangiectasia	Associate	12576328, 18353973, 22948311, 23447702, 24142626, 28031537, 29395063, 31649026, 31708417
Atherosclerosis	Associate	27740938
Breast Neoplasms	Associate	17055492, 18823530, 19716789, 21803008, 23917378, 25460505, 25468710, 25520248, 25688741, 26459098, 27167194, 29326282, 31441116, 31963582, 32210727 View all (7 more)
Breast Neoplasms	Inhibit	23825533
Breast Neoplasms Male	Associate	28808232
Calcinosis Cutis	Associate	24934408
Carcinogenesis	Associate	21440578, 23533280, 29963769
Carcinogenesis	Inhibit	30428154
Carcinoma Embryonal	Associate	19259937
Carcinoma Hepatocellular	Inhibit	27350734
Carcinoma Hepatocellular	Associate	27350734, 30228980, 30315225, 32596342, 33232580, 34087888, 36347033, 36403263
Carcinoma Non Small Cell Lung	Associate	15558813, 21179472, 24113549, 24418519, 25840419, 27553023, 30900384, 31140586, 32059076, 32161100, 34058013, 35348291, 37704455, 39513859
Carcinoma Ovarian Epithelial	Associate	33332934, 34474677
Carcinoma Renal Cell	Associate	32349972, 37464398
Carcinoma Small Cell	Associate	28766886
Carcinoma Squamous Cell	Associate	29118324, 29963769, 33162799, 36714024, 39694330
Cardiovascular Diseases	Associate	27740938
Cholangiocarcinoma	Associate	33200197
Chromosome Aberrations	Associate	35741017
Chromosome Disorders	Inhibit	23454898
Colitis Ulcerative	Associate	28751935
Colonic Neoplasms	Associate	19502782, 35392038
Colorectal Neoplasms	Associate	17848589, 18159231, 18632613, 24996846, 25301724, 27690730, 28389531, 28573382, 29082250, 31040255, 31173250, 32161100, 32503434, 35567913, 35881546, 36734271, 37237279, 37945594 View all (3 more)
Colorectal Neoplasms	Stimulate	29870526
COVID 19	Associate	33492566
Death	Inhibit	33754208
Dermatitis Atopic	Associate	36543921
Diabetes Mellitus Type 1	Inhibit	34681648
Disease	Associate	24142626
DNA Virus Infections	Associate	23112151, 23667469, 24505404, 24825908, 25972194, 26474283, 28698766, 31017975, 31649026, 38316371
DNA Virus Infections	Stimulate	27129240
Drug Related Side Effects and Adverse Reactions	Associate	15601819, 16931916, 19502782, 20599444, 21289283, 23242585, 23550703, 27690730, 28766886, 32210727, 34519926, 35430566, 36781846
Drug Related Side Effects and Adverse Reactions	Inhibit	22937147, 25565400, 27829224
Encephalitis Herpes Simplex	Associate	14726685
Endometrial Neoplasms	Associate	33754208
Epstein Barr Virus Infections	Associate	28031537
Esophageal Neoplasms	Associate	25450480
Esophageal Squamous Cell Carcinoma	Associate	31485619, 36991467
Fanconi Anemia	Associate	14988723, 17296736, 21183791, 26771352
Glioblastoma	Associate	22313687, 22481303, 30158599, 32897363, 35806055, 38003585, 39528802
Glioma	Associate	19001440, 22313687, 23667469, 30548945
Glycogen Storage Disease Type IV	Stimulate	30548945
Head and Neck Neoplasms	Associate	23839309, 29229598
Hepatitis B	Stimulate	18985806
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25104095
Hidradenitis Suppurativa	Associate	32240121
Hyperoxia	Stimulate	15533933
Hypoxia	Associate	12519769, 35806055
Hypoxia Brain	Associate	35806055
Immunologic Deficiency Syndromes	Associate	38316371
Infections	Associate	28031537, 33492566
Inflammation	Associate	27463284, 27740938, 37904396
Intervertebral Disc Degeneration	Associate	34545328, 36175893
Leukemia	Associate	15494423, 16854822, 23536721, 24913641, 35790845
Leukemia Lymphocytic Chronic B Cell	Associate	35994503
Leukemia Lymphoma Adult T Cell	Associate	37832654
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	32901871
Leukemia Myeloid	Associate	31431503, 35790845
Leukemia Myeloid Acute	Associate	22621920, 24179152, 27166183, 28030834, 34168220, 35790845
Li Fraumeni Syndrome	Associate	36553570
Light Fixation Seizure Syndrome	Associate	19401701
Liposarcoma	Stimulate	21335544
Lung Neoplasms	Associate	21179472, 23275151, 24441772, 25535897, 25840419, 26438152, 29118324, 30607635, 35178291, 36714024
Lupus Erythematosus Systemic	Associate	36306362
Lymphatic Metastasis	Associate	21803008
Lymphoma	Associate	24913641
Lymphoma Follicular	Associate	21960592, 22102710
Lymphoma Large B Cell Diffuse	Associate	18346918
Lymphoma Mantle Cell	Associate	26439697
Macular Degeneration	Associate	34629418
Medulloblastoma	Associate	27449089, 28383788
Melanoma	Associate	34281234, 37270643
Mesothelioma	Associate	22905093, 34580349
Mesothelioma Malignant	Stimulate	19218339
Microcephaly	Associate	16217032
Microcephaly Primary Autosomal Recessive 1	Associate	11481475, 16217032
Multiple Myeloma	Associate	21911831, 24594907, 25609078, 27010134, 31289205, 32060401, 33197893, 34782371
Nasopharyngeal Carcinoma	Associate	24197116
Necrosis	Stimulate	26319201
Necrosis	Associate	37904396
Neoplasm Recurrence Local	Associate	26459098
Neoplasms	Associate	14570880, 14726685, 15699047, 16931916, 18159231, 18632613, 19165865, 19502782, 19716789, 20516219, 20590661, 20696794, 20805228, 21281788, 21289283 View all (85 more)
Neoplasms	Inhibit	15096610, 15987455, 17010193, 22855742
Neoplasms	Stimulate	32121037
Neuroblastoma	Associate	21289283, 23892435, 29805983, 31362335, 34807483
Obesity	Associate	39256343
Organizing Pneumonia	Stimulate	30548945
Osteosarcoma	Associate	32033398, 40090437
Ovarian Neoplasms	Stimulate	22743332, 23383610
Ovarian Neoplasms	Associate	23548269, 23575069, 24240112, 25104095, 25474241, 25884494, 26992217, 28591191, 29575713, 31409614, 33352723, 35741017, 35977930, 37048111, 38114660
Paget Disease Extramammary	Associate	34292991
Pancreatic Neoplasms	Associate	18381943, 19139112, 19401701, 19519883, 22134241, 22244109, 25002126
Polyomavirus Infections	Associate	34372559
Pre Eclampsia	Stimulate	36834513
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	27438145
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	32349972
Prostatic Neoplasms	Associate	15961392, 24079846, 24525428, 31932554, 32459662, 36919124
Prostatic Neoplasms Castration Resistant	Associate	37011019
Radiation Injuries	Associate	38169561
Recombinant chromosome 8 syndrome	Associate	36627197
Rectal Neoplasms	Associate	30112378
Recurrence	Associate	33857852
Retinoblastoma	Associate	20664703
Sarcoma Ewing	Associate	30282812, 31649026, 40478628
Schizophrenia	Inhibit	23861893
Seckel syndrome 1	Associate	16217032
Sleep Deprivation	Associate	24913641
Small Cell Lung Carcinoma	Associate	24934408, 25185187, 29845250, 33320980, 33504652, 34719665
Smoke Inhalation Injury	Associate	27221653
Squamous Cell Carcinoma of Head and Neck	Associate	24142626, 24327542
Stomach Diseases	Associate	37904396
Stomach Neoplasms	Associate	20401435, 21999571, 25972194, 26867682, 30260263, 32902196, 35902562, 36578802, 37904396
Sucrase isomaltase deficiency congenital	Inhibit	19165865
Tetraploidy	Associate	18159231
Thyroid Cancer Papillary	Associate	25868389
Thyroid Neoplasms	Associate	27329729
Triple Negative Breast Neoplasms	Inhibit	23825533
Triple Negative Breast Neoplasms	Associate	25104095, 27272773, 30607635, 31963582, 32294924, 35430566, 36720923, 36998242, 40037423, 40179432
Urethral Neoplasms	Associate	27191498, 28049532
Urinary Bladder Neoplasms	Associate	27246979, 39892702
Uterine Cervical Neoplasms	Associate	25386925
Vulvar Neoplasms	Associate	29963769
Werner Syndrome	Inhibit	30657978
Williams Syndrome	Associate	28098859

CHEK1 (checkpoint kinase 1)