ADAM30 (ADAM metallopeptidase domain 30)

Gene

• Entrez ID: 11085
• Gene name: ADAM metallopeptidase domain 30
• Gene symbol: ADAM30
• Synonyms (NCBI Gene): svph4
• Chromosome: 1
• Chromosome location: 1p12
• Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT766148	hsa-miR-1321	CLIP-seq
MIRT766149	hsa-miR-1827	CLIP-seq
MIRT766150	hsa-miR-23a	CLIP-seq
MIRT766151	hsa-miR-23b	CLIP-seq
MIRT766152	hsa-miR-23c	CLIP-seq
MIRT766153	hsa-miR-2467-3p	CLIP-seq
MIRT766154	hsa-miR-3126-5p	CLIP-seq
MIRT766155	hsa-miR-3166	CLIP-seq
MIRT766156	hsa-miR-3612	CLIP-seq
MIRT766157	hsa-miR-4419a	CLIP-seq
MIRT766158	hsa-miR-4466	CLIP-seq
MIRT766159	hsa-miR-4510	CLIP-seq
MIRT766160	hsa-miR-4717-3p	CLIP-seq
MIRT766161	hsa-miR-4739	CLIP-seq
MIRT766162	hsa-miR-4756-5p	CLIP-seq
MIRT766163	hsa-miR-4802-3p	CLIP-seq
MIRT766164	hsa-miR-490-5p	CLIP-seq
MIRT766165	hsa-miR-650	CLIP-seq
MIRT766166	hsa-miR-675	CLIP-seq
MIRT766150	hsa-miR-23a	CLIP-seq
MIRT766151	hsa-miR-23b	CLIP-seq
MIRT766152	hsa-miR-23c	CLIP-seq
MIRT766158	hsa-miR-4466	CLIP-seq
MIRT766160	hsa-miR-4717-3p	CLIP-seq
MIRT766163	hsa-miR-4802-3p	CLIP-seq
MIRT766164	hsa-miR-490-5p	CLIP-seq
MIRT766166	hsa-miR-675	CLIP-seq
MIRT2167118	hsa-miR-764	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	10512762
GO:0008270	Function	Zinc ion binding	TAS	10512762
GO:0008584	Process	Male gonad development	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10512762
GO:0016787	Function	Hydrolase activity	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990913	Component	Sperm head plasma membrane	IBA
GO:1990913	Component	Sperm head plasma membrane	IEA

Other IDs

• MIM: 604779
• HGNC: 208
• e!Ensembl: ENSG00000134249

Protein

• UniProt ID: Q9UKF2
• Protein name: Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-)
• Protein function: Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	30 → 160	Reprolysin family propeptide	Family
  PF01421	Reprolysin	203 → 393	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF00200	Disintegrin	408 → 480	Disintegrin	Domain
  PF08516	ADAM_CR	485 → 603	ADAM cysteine-rich	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain neurons (at protein level) (PubMed:27333034). Expressed in testis (PubMed:10512762). {ECO:0000269|PubMed:10512762, ECO:0000269|PubMed:27333034}.
• Sequence:

  MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVS
  PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL
  DSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIE
  WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY
  FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK
  YNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLN
  CIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEE
  CQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPND
  VYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITG
  IRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGI
  PDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPF
  CEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQ
  EKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRP
  KAKSVKKQKK

• Sequence length: 790

Pathways

Reactome:

Interaction With Cumulus Cells And The Zona Pellucida