UBE2C (ubiquitin conjugating enzyme E2 C)

Gene

• Entrez ID: 11065
• Gene name: Ubiquitin conjugating enzyme E2 C
• Gene symbol: UBE2C
• Synonyms (NCBI Gene): UBCH10, dJ447F3.2
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating e

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016310	hsa-miR-193b-3p	Microarray	20304954
MIRT021680	hsa-miR-140-3p	Sequencing	20371350
MIRT030369	hsa-miR-24-3p	Microarray	19748357
MIRT031394	hsa-miR-16-5p	Proteomics	18668040
MIRT050874	hsa-miR-17-5p	CLASH	23622248
MIRT050549	hsa-miR-20a-5p	CLASH	23622248
MIRT048197	hsa-miR-196a-5p	CLASH	23622248
MIRT040327	hsa-miR-615-3p	CLASH	23622248
MIRT039262	hsa-miR-671-5p	CLASH	23622248
MIRT050874	hsa-miR-17-5p	Luciferase reporter assay, qRT-PCR, Western blot	25760688
MIRT050874	hsa-miR-17-5p	Luciferase reporter assay, qRT-PCR, Western blot	25760688
MIRT050549	hsa-miR-20a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25760688
MIRT050549	hsa-miR-20a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25760688
MIRT736651	hsa-miR-381-3p	Luciferase reporter assay, Western blotting, qRT-PCR	31646760
MIRT756334	hsa-miR-4429	Luciferase reporter assay, Western blotting, qRT-PCR	35866591
MIRT1467069	hsa-miR-300	CLIP-seq
MIRT1467070	hsa-miR-3188	CLIP-seq
MIRT1467071	hsa-miR-381	CLIP-seq
MIRT1467072	hsa-miR-4437	CLIP-seq
MIRT1467073	hsa-miR-4666-3p	CLIP-seq
MIRT1467074	hsa-miR-4729	CLIP-seq
MIRT1467075	hsa-miR-4775	CLIP-seq
MIRT1467076	hsa-miR-624	CLIP-seq
MIRT1467077	hsa-miR-889	CLIP-seq
MIRT2361098	hsa-miR-1276	CLIP-seq
MIRT2361099	hsa-miR-1284	CLIP-seq
MIRT2361100	hsa-miR-337-3p	CLIP-seq
MIRT2361101	hsa-miR-4311	CLIP-seq
MIRT2361102	hsa-miR-4719	CLIP-seq
MIRT2361103	hsa-miR-577	CLIP-seq
MIRT2361104	hsa-miR-583	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MED1	Unknown	21556051
MYC	Activation	22170434

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IDA	15749827
GO:0000209	Process	Protein polyubiquitination	IBA	21873635
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	20061386
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	18485873, 19820702, 19822757
GO:0005515	Function	Protein binding	IPI	19822757, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005680	Component	Anaphase-promoting complex	IDA	18485873, 19822757
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	9122200, 18485873
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS
GO:0010458	Process	Exit from mitosis	IMP	19822757
GO:0010994	Process	Free ubiquitin chain polymerization	IDA	19822757
GO:0016567	Process	Protein ubiquitination	IDA	9122200
GO:0016567	Process	Protein ubiquitination	TAS
GO:0030071	Process	Regulation of mitotic metaphase/anaphase transition	IBA	21873635
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	IBA	21873635
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	IDA	9122200, 19822757
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	TAS
GO:0031536	Process	Positive regulation of exit from mitosis	IMP	9122200
GO:0044389	Function	Ubiquitin-like protein ligase binding	IPI	15749827
GO:0051301	Process	Cell division	IEA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA	21873635
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IDA	12629039
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	20061386
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	18485873, 19822757, 20061386
GO:1901990	Process	Regulation of mitotic cell cycle phase transition	TAS
GO:1904668	Process	Positive regulation of ubiquitin protein ligase activity	TAS	17443180

Other IDs

• MIM: 605574
• HGNC: 15937
• e!Ensembl: ENSG00000175063

Protein

• UniProt ID: O00762
• Protein name: Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
• Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C),
• PDB: 1I7K, 4YII, 5A31, 5KHR, 5L9U, 8TAR, 8TAU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00179	UQ_con	34 → 170	Ubiquitin-conjugating enzyme	Domain

• Sequence:

  MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF
  KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE
  KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP

• Sequence length: 179

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	17659439
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	17659439
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	17659439

Associations from Text Mining
Disease Name	Relationship Type	References
Acquired ichthyosis	Associate	36303457
Adenocarcinoma	Associate	17217624
Adenocarcinoma	Stimulate	36434043
Adenocarcinoma Follicular	Associate	32093341
Adenocarcinoma of Lung	Associate	19638491, 23357462, 31698633, 33126397, 36434043
Adenocarcinoma of Lung	Stimulate	22388643
Adrenocortical Carcinoma	Associate	34918636, 37535572
Astrocytoma	Associate	18666437
Brain Neoplasms	Associate	18666437
Breast Neoplasms	Associate	19038004, 22056852, 24699941, 25739083, 29685151, 33313822, 34620747, 34675265, 35124721, 37893423, 38643462, 39684488
Calcinosis	Associate	24699941
Carcinogenesis	Associate	21338529, 31037155, 31715067, 33782624
Carcinoma Hepatocellular	Associate	22997493, 30702595, 30914455, 32046048, 32685988, 32703154, 34238253, 34315286, 36882493, 37580802
Carcinoma Non Small Cell Lung	Stimulate	19638491, 31037155
Carcinoma Non Small Cell Lung	Associate	30146342, 31805030, 33008389, 35422093, 40282365
Carcinoma Ovarian Epithelial	Associate	31725636
Carcinoma Pancreatic Ductal	Associate	23355337, 29483831, 31715067
Carcinoma Renal Cell	Associate	31422942, 32309427, 33782624, 36385010
Carcinoma Small Cell	Stimulate	22388643
Carcinoma Squamous Cell	Stimulate	38009019
Cholangiocarcinoma	Associate	38102624
Colitis	Associate	30227886
Colorectal Neoplasms	Associate	19302711, 19359472, 31173250, 36303457, 38637125
COVID 19	Associate	35749386, 36201886, 36551164, 36856850, 40224213
Death	Associate	22056852
Diabetes Mellitus Type 1	Associate	36303457
Diarrhea	Associate	30227886
Dysplastic Nevus Syndrome	Stimulate	17217624
Endometrial Hyperplasia	Associate	28951454
Endometrial Neoplasms	Associate	37335710, 37803076
Esophageal atresia with or without tracheoesophageal fistula	Associate	17217624
Esophageal Neoplasms	Associate	32443386, 34232175, 34488675, 35568702
Esophageal Squamous Cell Carcinoma	Associate	27556859, 34232175, 34488675, 37168048
Esophageal Squamous Cell Carcinoma	Stimulate	27588470
Fatty Liver Alcoholic	Associate	32685988
Gamma A Globulin Defect in Assembly of	Associate	33008389
Glioblastoma	Associate	18666437
Glioma	Associate	28767320
Hematuria	Associate	27528424
Hereditary Breast and Ovarian Cancer Syndrome	Associate	24699941
Infertility	Associate	36303457
Kidney Neoplasms	Associate	36385010
Leukemia Myeloid Acute	Associate	30480765
Light Fixation Seizure Syndrome	Associate	26894859
Lung Diseases	Stimulate	19638491
Lung Neoplasms	Associate	22388643, 24815438, 30146342, 34257576, 35178291, 35422093, 40282365
Lymphatic Metastasis	Stimulate	23355337, 23587173, 35615976, 37335710
Lymphatic Metastasis	Associate	29630110, 31725636, 37168048
Lymphatic Metastasis	Inhibit	31715067
Melanoma	Associate	36303457
Mesothelioma Malignant	Associate	33032291
Mouth Neoplasms	Associate	37641028
Nasopharyngeal Carcinoma	Associate	18570662, 23587173, 36576436, 39334908
Nasopharyngeal Neoplasms	Associate	36576436
Neoplasm Invasiveness	Associate	23201130
Neoplasm Metastasis	Stimulate	23587173
Neoplasm Metastasis	Associate	31037155, 38102624, 39334908
Neoplasms	Stimulate	17217624, 21338529, 27528424, 35615976, 37803076
Neoplasms	Associate	18570662, 18666437, 19038004, 19302711, 19359472, 19509549, 20544706, 21169070, 22056852, 22388643, 23355337, 23587173, 23826418, 26894859, 27322462, 27588470, 28260026, 28767320, 29575713, 29630110, 31037155, 31067633, 31715067, 32685988, 33008389, 34315286, 34620747, 34728699, 34950739, 35124721, 35812372, 36069832, 36303457, 36385010, 36434043, 37168048, 37335710, 37535572, 37958642, 38009019, 38096163, 38102624, 40282365
Neuroblastoma	Associate	23251412
Osteochondritis	Associate	31758856
Ovarian Neoplasms	Associate	29575713, 34577856, 40282365
Pancreatic Neoplasms	Associate	29483831
Phyllodes Tumor	Associate	37240386
Polycystic Ovary Syndrome	Associate	25432544
Precancerous Conditions	Associate	24699941
Primary Ovarian Insufficiency	Associate	37848988
Prostatic Neoplasms	Associate	33630978, 35409038, 36430352, 36834602, 38179769, 38226611, 39201599
Prostatic Neoplasms Castration Resistant	Associate	21556051, 25481872
Small Cell Lung Carcinoma	Associate	33186389
Squamous Cell Carcinoma of Head and Neck	Associate	34198450, 35615976
Squamous Cell Carcinoma of Head and Neck	Stimulate	34950739, 36069832, 38096163
Stomach Neoplasms	Inhibit	28260026
Stomach Neoplasms	Associate	29630110, 30804389, 32908877, 38062820, 40224213
Thyroid Neoplasms	Associate	20544706
Thyroiditis	Associate	20544706
Tissue Adhesions	Associate	34968168
Urethral Neoplasms	Associate	23201130
Urinary Bladder Neoplasms	Associate	23201130, 23826418, 27528424
Uterine Cervical Neoplasms	Associate	21338529