Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11031
Gene name Gene Name - the full gene name approved by the HGNC.
RAB31, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB31
Synonyms (NCBI Gene) Gene synonyms aliases
Rab22B
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18p11.22
Summary Summary of gene provided in NCBI Entrez Gene.
Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021663 hsa-miR-140-3p Sequencing 20371350
MIRT022839 hsa-miR-124-3p Microarray 18668037
MIRT026067 hsa-miR-196a-5p Sequencing 20371350
MIRT720464 hsa-miR-1255b-2-3p HITS-CLIP 19536157
MIRT720463 hsa-miR-6834-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001891 Component Phagocytic cup ISS
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 23055524, 32296183, 32814053
GO:0005525 Function GTP binding IDA 17189207
GO:0005769 Component Early endosome IDA 17189207
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605694 9771 ENSG00000168461
Protein
UniProt ID Q13636
Protein name Ras-related protein Rab-31 (EC 3.6.5.2) (Ras-related protein Rab-22B)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form
PDB 2FG5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 7 168 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. {ECO:0000269|PubMed:11784320}.
Sequence
Sequence length 194
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis   Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
28604730
Osteoporosis Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 28580392
Unknown
Disease term Disease name Evidence References Source
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 30124448
Astrocytoma Associate 23737970
Bowen's Disease Associate 36085041
Breast Neoplasms Associate 22792175, 30431262, 34906074
Calcinosis Cutis Stimulate 37222416
Carcinoma Hepatocellular Stimulate 26044564
Carcinoma Non Small Cell Lung Associate 39849454
Carcinoma Squamous Cell Associate 36085041
Eosinophilic Esophagitis Associate 35839075
Glioblastoma Associate 21649900, 23737970