Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10988
Gene name Gene Name - the full gene name approved by the HGNC.	Methionyl aminopeptidase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	METAP2
Synonyms (NCBI Gene) Gene synonyms aliases	MAP2, MNPEP, p67eIF2
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q22
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal me

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020542	hsa-miR-155-5p	Proteomics	18668040
MIRT022163	hsa-miR-124-3p	Microarray	18668037
MIRT030371	hsa-miR-24-3p	Microarray	19748357
MIRT031408	hsa-miR-16-5p	Proteomics	18668040
MIRT051737	hsa-let-7c-5p	CLASH	23622248
MIRT713768	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713767	hsa-miR-4277	HITS-CLIP	19536157
MIRT713766	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT713765	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	21572407
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	21572407
MIRT067592	hsa-miR-3163	PAR-CLIP	21572407
MIRT067587	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT556140	hsa-miR-4289	PAR-CLIP	21572407
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	21572407
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT449771	hsa-miR-5701	PAR-CLIP	22100165
MIRT449770	hsa-miR-7108-5p	PAR-CLIP	22100165
MIRT449769	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT067540	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT067541	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT713768	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713767	hsa-miR-4277	HITS-CLIP	19536157
MIRT713766	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT713765	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	21572407
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	21572407
MIRT067592	hsa-miR-3163	PAR-CLIP	21572407
MIRT067587	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT556140	hsa-miR-4289	PAR-CLIP	21572407
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	21572407
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT449771	hsa-miR-5701	PAR-CLIP	22100165
MIRT449770	hsa-miR-7108-5p	PAR-CLIP	22100165
MIRT449769	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT1143588	hsa-miR-1179	CLIP-seq
MIRT1143589	hsa-miR-124	CLIP-seq
MIRT1143590	hsa-miR-1243	CLIP-seq
MIRT1143591	hsa-miR-1246	CLIP-seq
MIRT1143592	hsa-miR-1269	CLIP-seq
MIRT1143593	hsa-miR-1269b	CLIP-seq
MIRT1143594	hsa-miR-1297	CLIP-seq
MIRT1143595	hsa-miR-1305	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT1143597	hsa-miR-183	CLIP-seq
MIRT1143598	hsa-miR-2053	CLIP-seq
MIRT1143599	hsa-miR-224	CLIP-seq
MIRT1143600	hsa-miR-26a	CLIP-seq
MIRT1143601	hsa-miR-26b	CLIP-seq
MIRT1143602	hsa-miR-298	CLIP-seq
MIRT1143603	hsa-miR-3119	CLIP-seq
MIRT1143604	hsa-miR-3120-3p	CLIP-seq
MIRT1143605	hsa-miR-3129-3p	CLIP-seq
MIRT1143606	hsa-miR-3152-5p	CLIP-seq
MIRT1143607	hsa-miR-330-3p	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143609	hsa-miR-3591-3p	CLIP-seq
MIRT1143610	hsa-miR-3653	CLIP-seq
MIRT1143611	hsa-miR-3658	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT1143614	hsa-miR-384	CLIP-seq
MIRT1143615	hsa-miR-409-3p	CLIP-seq
MIRT1143616	hsa-miR-4271	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT1143618	hsa-miR-4310	CLIP-seq
MIRT1143619	hsa-miR-4320	CLIP-seq
MIRT1143620	hsa-miR-4422	CLIP-seq
MIRT1143621	hsa-miR-4423-5p	CLIP-seq
MIRT1143622	hsa-miR-4465	CLIP-seq
MIRT1143623	hsa-miR-4476	CLIP-seq
MIRT1143624	hsa-miR-4484	CLIP-seq
MIRT1143625	hsa-miR-4509	CLIP-seq
MIRT1143626	hsa-miR-4520b-3p	CLIP-seq
MIRT1143627	hsa-miR-4529-3p	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT1143629	hsa-miR-4694-3p	CLIP-seq
MIRT1143630	hsa-miR-4725-3p	CLIP-seq
MIRT1143631	hsa-miR-4735-5p	CLIP-seq
MIRT1143632	hsa-miR-4747-5p	CLIP-seq
MIRT1143633	hsa-miR-4764-5p	CLIP-seq
MIRT1143634	hsa-miR-4774-3p	CLIP-seq
MIRT1143635	hsa-miR-485-3p	CLIP-seq
MIRT1143636	hsa-miR-506	CLIP-seq
MIRT1143637	hsa-miR-548aa	CLIP-seq
MIRT1143638	hsa-miR-548ag	CLIP-seq
MIRT1143639	hsa-miR-548ai	CLIP-seq
MIRT1143640	hsa-miR-548an	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143642	hsa-miR-548n	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT1143644	hsa-miR-649	CLIP-seq
MIRT1143645	hsa-miR-665	CLIP-seq
MIRT1143588	hsa-miR-1179	CLIP-seq
MIRT1143590	hsa-miR-1243	CLIP-seq
MIRT1143594	hsa-miR-1297	CLIP-seq
MIRT1143595	hsa-miR-1305	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT2040885	hsa-miR-186	CLIP-seq
MIRT2040886	hsa-miR-199a-3p	CLIP-seq
MIRT2040887	hsa-miR-199b-3p	CLIP-seq
MIRT1143600	hsa-miR-26a	CLIP-seq
MIRT1143601	hsa-miR-26b	CLIP-seq
MIRT1143602	hsa-miR-298	CLIP-seq
MIRT2040888	hsa-miR-3129-5p	CLIP-seq
MIRT2040889	hsa-miR-3148	CLIP-seq
MIRT1143606	hsa-miR-3152-5p	CLIP-seq
MIRT2040890	hsa-miR-3179	CLIP-seq
MIRT2040891	hsa-miR-3202	CLIP-seq
MIRT2040892	hsa-miR-323-3p	CLIP-seq
MIRT1143607	hsa-miR-330-3p	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143609	hsa-miR-3591-3p	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT1143614	hsa-miR-384	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT2040893	hsa-miR-4305	CLIP-seq
MIRT1143619	hsa-miR-4320	CLIP-seq
MIRT1143620	hsa-miR-4422	CLIP-seq
MIRT1143622	hsa-miR-4465	CLIP-seq
MIRT1143623	hsa-miR-4476	CLIP-seq
MIRT2040894	hsa-miR-4646-3p	CLIP-seq
MIRT2040895	hsa-miR-4668-5p	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT2040896	hsa-miR-4727-3p	CLIP-seq
MIRT1143633	hsa-miR-4764-5p	CLIP-seq
MIRT1143634	hsa-miR-4774-3p	CLIP-seq
MIRT2040897	hsa-miR-4775	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT1143645	hsa-miR-665	CLIP-seq
MIRT2040898	hsa-miR-936	CLIP-seq
MIRT2270542	hsa-miR-105	CLIP-seq
MIRT1143588	hsa-miR-1179	CLIP-seq
MIRT1143590	hsa-miR-1243	CLIP-seq
MIRT1143594	hsa-miR-1297	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT1143597	hsa-miR-183	CLIP-seq
MIRT1143599	hsa-miR-224	CLIP-seq
MIRT1143600	hsa-miR-26a	CLIP-seq
MIRT1143601	hsa-miR-26b	CLIP-seq
MIRT1143602	hsa-miR-298	CLIP-seq
MIRT2270543	hsa-miR-3123	CLIP-seq
MIRT1143605	hsa-miR-3129-3p	CLIP-seq
MIRT2040889	hsa-miR-3148	CLIP-seq
MIRT2040890	hsa-miR-3179	CLIP-seq
MIRT2040891	hsa-miR-3202	CLIP-seq
MIRT1143607	hsa-miR-330-3p	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143609	hsa-miR-3591-3p	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT1143614	hsa-miR-384	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT2040893	hsa-miR-4305	CLIP-seq
MIRT1143620	hsa-miR-4422	CLIP-seq
MIRT1143622	hsa-miR-4465	CLIP-seq
MIRT1143623	hsa-miR-4476	CLIP-seq
MIRT2270544	hsa-miR-4662a-5p	CLIP-seq
MIRT2040895	hsa-miR-4668-5p	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT1143631	hsa-miR-4735-5p	CLIP-seq
MIRT1143633	hsa-miR-4764-5p	CLIP-seq
MIRT1143638	hsa-miR-548ag	CLIP-seq
MIRT1143639	hsa-miR-548ai	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143642	hsa-miR-548n	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT2270542	hsa-miR-105	CLIP-seq
MIRT2569687	hsa-miR-1200	CLIP-seq
MIRT2569688	hsa-miR-1264	CLIP-seq
MIRT1143592	hsa-miR-1269	CLIP-seq
MIRT1143593	hsa-miR-1269b	CLIP-seq
MIRT2569689	hsa-miR-144	CLIP-seq
MIRT2569690	hsa-miR-198	CLIP-seq
MIRT1143599	hsa-miR-224	CLIP-seq
MIRT2569691	hsa-miR-2681	CLIP-seq
MIRT2569692	hsa-miR-29a	CLIP-seq
MIRT2569693	hsa-miR-29b	CLIP-seq
MIRT2569694	hsa-miR-29c	CLIP-seq
MIRT2569695	hsa-miR-3065-5p	CLIP-seq
MIRT1143603	hsa-miR-3119	CLIP-seq
MIRT1143604	hsa-miR-3120-3p	CLIP-seq
MIRT2270543	hsa-miR-3123	CLIP-seq
MIRT2569696	hsa-miR-3124-3p	CLIP-seq
MIRT2569697	hsa-miR-3140-5p	CLIP-seq
MIRT1143606	hsa-miR-3152-5p	CLIP-seq
MIRT2569698	hsa-miR-3194-3p	CLIP-seq
MIRT2569699	hsa-miR-3545-3p	CLIP-seq
MIRT1143610	hsa-miR-3653	CLIP-seq
MIRT1143611	hsa-miR-3658	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT2569700	hsa-miR-3688-5p	CLIP-seq
MIRT2569701	hsa-miR-3919	CLIP-seq
MIRT2569702	hsa-miR-3923	CLIP-seq
MIRT1143615	hsa-miR-409-3p	CLIP-seq
MIRT2569703	hsa-miR-412	CLIP-seq
MIRT1143616	hsa-miR-4271	CLIP-seq
MIRT2569704	hsa-miR-4275	CLIP-seq
MIRT2569705	hsa-miR-4307	CLIP-seq
MIRT1143618	hsa-miR-4310	CLIP-seq
MIRT2569706	hsa-miR-4326	CLIP-seq
MIRT2569707	hsa-miR-4433	CLIP-seq
MIRT2569708	hsa-miR-4459	CLIP-seq
MIRT2569709	hsa-miR-4470	CLIP-seq
MIRT2569710	hsa-miR-4480	CLIP-seq
MIRT2569711	hsa-miR-4490	CLIP-seq
MIRT1143626	hsa-miR-4520b-3p	CLIP-seq
MIRT1143627	hsa-miR-4529-3p	CLIP-seq
MIRT2569712	hsa-miR-4645-3p	CLIP-seq
MIRT2569713	hsa-miR-4645-5p	CLIP-seq
MIRT2569714	hsa-miR-4673	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT2569715	hsa-miR-4724-5p	CLIP-seq
MIRT1143630	hsa-miR-4725-3p	CLIP-seq
MIRT1143632	hsa-miR-4747-5p	CLIP-seq
MIRT2569716	hsa-miR-4768-3p	CLIP-seq
MIRT1143634	hsa-miR-4774-3p	CLIP-seq
MIRT2569717	hsa-miR-4774-5p	CLIP-seq
MIRT2569718	hsa-miR-548m	CLIP-seq
MIRT2569719	hsa-miR-621	CLIP-seq
MIRT2569720	hsa-miR-628-3p	CLIP-seq
MIRT1143644	hsa-miR-649	CLIP-seq
MIRT2270542	hsa-miR-105	CLIP-seq
MIRT2569687	hsa-miR-1200	CLIP-seq
MIRT1143592	hsa-miR-1269	CLIP-seq
MIRT1143593	hsa-miR-1269b	CLIP-seq
MIRT2569689	hsa-miR-144	CLIP-seq
MIRT2569690	hsa-miR-198	CLIP-seq
MIRT2569691	hsa-miR-2681	CLIP-seq
MIRT2569692	hsa-miR-29a	CLIP-seq
MIRT2569693	hsa-miR-29b	CLIP-seq
MIRT2569694	hsa-miR-29c	CLIP-seq
MIRT2569695	hsa-miR-3065-5p	CLIP-seq
MIRT1143603	hsa-miR-3119	CLIP-seq
MIRT2270543	hsa-miR-3123	CLIP-seq
MIRT2569697	hsa-miR-3140-5p	CLIP-seq
MIRT2569698	hsa-miR-3194-3p	CLIP-seq
MIRT2569699	hsa-miR-3545-3p	CLIP-seq
MIRT2569700	hsa-miR-3688-5p	CLIP-seq
MIRT2569701	hsa-miR-3919	CLIP-seq
MIRT2569702	hsa-miR-3923	CLIP-seq
MIRT2569705	hsa-miR-4307	CLIP-seq
MIRT2569709	hsa-miR-4470	CLIP-seq
MIRT2569710	hsa-miR-4480	CLIP-seq
MIRT2569711	hsa-miR-4490	CLIP-seq
MIRT1143626	hsa-miR-4520b-3p	CLIP-seq
MIRT1143627	hsa-miR-4529-3p	CLIP-seq
MIRT2569712	hsa-miR-4645-3p	CLIP-seq
MIRT2569713	hsa-miR-4645-5p	CLIP-seq
MIRT2569714	hsa-miR-4673	CLIP-seq
MIRT2569715	hsa-miR-4724-5p	CLIP-seq
MIRT2569717	hsa-miR-4774-5p	CLIP-seq
MIRT2569718	hsa-miR-548m	CLIP-seq
MIRT2569719	hsa-miR-621	CLIP-seq
MIRT2569720	hsa-miR-628-3p	CLIP-seq
MIRT2684840	hsa-miR-767-5p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
PLAGL2	Activation	17462995

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0004177	Function	Aminopeptidase activity	IDA	8858118
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005737	Component	Cytoplasm	IDA	15102683
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0008235	Function	Metalloexopeptidase activity	IDA	8858118
GO:0016485	Process	Protein processing	IDA	8858118
GO:0018206	Process	Peptidyl-methionine modification	IDA	8858118
GO:0022400	Process	Regulation of rhodopsin mediated signaling pathway	TAS
GO:0031365	Process	N-terminal protein amino acid modification	IDA	8858118
GO:0046872	Function	Metal ion binding	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IEA
GO:0070084	Process	Protein initiator methionine removal	IEA

MIM	HGNC	e!Ensembl
601870	16672	ENSG00000111142

Protein

UniProt ID

P50579

Protein name

Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)

Protein function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalyt

PDB

1B59 , 1B6A , 1BN5 , 1BOA , 1KQ0 , 1KQ9 , 1QZY , 1R58 , 1R5G , 1R5H , 1YW7 , 1YW8 , 1YW9 , 2ADU , 2EA2 , 2EA4 , 2GA2 , 2OAZ , 5CLS , 5D6E , 5D6F , 5JFR , 5JHU , 5JI6 , 5LYW , 5LYX , 6QED , 6QEF , 6QEG , 6QEH , 6QEI , 6QEJ , 7A12 , 7A13 , 7A14 , 7A15 , 7A16 , 8ONY , 8OXG , 9FPZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00557	Peptidase_M24	167 → 466	Metallopeptidase family M24	Domain

Sequence

MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Sequence length

478

Interactions

View interactions

	Reactome
			Inactivation, recovery and regulation of the phototransduction cascade

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	26935506
Astrocytoma	Associate	23161775
Autoimmune Diseases	Associate	34143178
Carcinoma Non Small Cell Lung	Associate	26935506
Carcinoma Ovarian Epithelial	Associate	32922205
Carcinoma Squamous Cell	Associate	26935506
Cholangiocarcinoma	Associate	23480755, 23480758, 30880771
Colorectal Neoplasms	Associate	19703310
Communicable Diseases	Associate	29579063
Graves Ophthalmopathy	Associate	36076300
Hypertension	Associate	34143178
Idiopathic Noncirrhotic Portal Hypertension	Associate	36312597
Inflammation	Associate	36312597
Lymphoma B Cell	Associate	12118091
Lymphoma Large B Cell Diffuse	Associate	12118091
Mesothelioma	Associate	11485930, 12118091
Neoplasm Metastasis	Associate	32922205
Neoplasms	Associate	11485930, 23480755, 26935506, 27542228, 29579063, 34913067

METAP2 (methionyl aminopeptidase 2)