METAP2 (methionyl aminopeptidase 2)

Gene

• Entrez ID: 10988
• Gene name: Methionyl aminopeptidase 2
• Gene symbol: METAP2
• Synonyms (NCBI Gene): MAP2, MNPEP, p67eIF2
• Chromosome: 12
• Chromosome location: 12q22
• Summary: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal me

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020542	hsa-miR-155-5p	Proteomics	18668040
MIRT022163	hsa-miR-124-3p	Microarray	18668037
MIRT030371	hsa-miR-24-3p	Microarray	19748357
MIRT031408	hsa-miR-16-5p	Proteomics	18668040
MIRT051737	hsa-let-7c-5p	CLASH	23622248
MIRT713768	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713767	hsa-miR-4277	HITS-CLIP	19536157
MIRT713766	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT713765	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	21572407
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	21572407
MIRT067592	hsa-miR-3163	PAR-CLIP	21572407
MIRT067587	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT556140	hsa-miR-4289	PAR-CLIP	21572407
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	21572407
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT449771	hsa-miR-5701	PAR-CLIP	22100165
MIRT449770	hsa-miR-7108-5p	PAR-CLIP	22100165
MIRT449769	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT067540	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT067541	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT713768	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713767	hsa-miR-4277	HITS-CLIP	19536157
MIRT713766	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT713765	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	20371350
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT067592	hsa-miR-3163	PAR-CLIP	20371350
MIRT067587	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT067589	hsa-miR-324-5p	PAR-CLIP	21572407
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	21572407
MIRT067592	hsa-miR-3163	PAR-CLIP	21572407
MIRT067587	hsa-miR-95-5p	PAR-CLIP	21572407
MIRT556140	hsa-miR-4289	PAR-CLIP	21572407
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	21572407
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT067589	hsa-miR-324-5p	PAR-CLIP	23446348
MIRT067593	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT067588	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT067592	hsa-miR-3163	PAR-CLIP	23446348
MIRT067587	hsa-miR-95-5p	PAR-CLIP	23446348
MIRT506585	hsa-miR-6758-3p	PAR-CLIP	23446348
MIRT449771	hsa-miR-5701	PAR-CLIP	22100165
MIRT449770	hsa-miR-7108-5p	PAR-CLIP	22100165
MIRT449769	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT1143588	hsa-miR-1179	CLIP-seq
MIRT1143589	hsa-miR-124	CLIP-seq
MIRT1143590	hsa-miR-1243	CLIP-seq
MIRT1143591	hsa-miR-1246	CLIP-seq
MIRT1143592	hsa-miR-1269	CLIP-seq
MIRT1143593	hsa-miR-1269b	CLIP-seq
MIRT1143594	hsa-miR-1297	CLIP-seq
MIRT1143595	hsa-miR-1305	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT1143597	hsa-miR-183	CLIP-seq
MIRT1143598	hsa-miR-2053	CLIP-seq
MIRT1143599	hsa-miR-224	CLIP-seq
MIRT1143600	hsa-miR-26a	CLIP-seq
MIRT1143601	hsa-miR-26b	CLIP-seq
MIRT1143602	hsa-miR-298	CLIP-seq
MIRT1143603	hsa-miR-3119	CLIP-seq
MIRT1143604	hsa-miR-3120-3p	CLIP-seq
MIRT1143605	hsa-miR-3129-3p	CLIP-seq
MIRT1143606	hsa-miR-3152-5p	CLIP-seq
MIRT1143607	hsa-miR-330-3p	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143609	hsa-miR-3591-3p	CLIP-seq
MIRT1143610	hsa-miR-3653	CLIP-seq
MIRT1143611	hsa-miR-3658	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT1143614	hsa-miR-384	CLIP-seq
MIRT1143615	hsa-miR-409-3p	CLIP-seq
MIRT1143616	hsa-miR-4271	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT1143618	hsa-miR-4310	CLIP-seq
MIRT1143619	hsa-miR-4320	CLIP-seq
MIRT1143620	hsa-miR-4422	CLIP-seq
MIRT1143621	hsa-miR-4423-5p	CLIP-seq
MIRT1143622	hsa-miR-4465	CLIP-seq
MIRT1143623	hsa-miR-4476	CLIP-seq
MIRT1143624	hsa-miR-4484	CLIP-seq
MIRT1143625	hsa-miR-4509	CLIP-seq
MIRT1143626	hsa-miR-4520b-3p	CLIP-seq
MIRT1143627	hsa-miR-4529-3p	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT1143629	hsa-miR-4694-3p	CLIP-seq
MIRT1143630	hsa-miR-4725-3p	CLIP-seq
MIRT1143631	hsa-miR-4735-5p	CLIP-seq
MIRT1143632	hsa-miR-4747-5p	CLIP-seq
MIRT1143633	hsa-miR-4764-5p	CLIP-seq
MIRT1143634	hsa-miR-4774-3p	CLIP-seq
MIRT1143635	hsa-miR-485-3p	CLIP-seq
MIRT1143636	hsa-miR-506	CLIP-seq
MIRT1143637	hsa-miR-548aa	CLIP-seq
MIRT1143638	hsa-miR-548ag	CLIP-seq
MIRT1143639	hsa-miR-548ai	CLIP-seq
MIRT1143640	hsa-miR-548an	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143642	hsa-miR-548n	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT1143644	hsa-miR-649	CLIP-seq
MIRT1143645	hsa-miR-665	CLIP-seq
MIRT1143588	hsa-miR-1179	CLIP-seq
MIRT1143590	hsa-miR-1243	CLIP-seq
MIRT1143594	hsa-miR-1297	CLIP-seq
MIRT1143595	hsa-miR-1305	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT2040885	hsa-miR-186	CLIP-seq
MIRT2040886	hsa-miR-199a-3p	CLIP-seq
MIRT2040887	hsa-miR-199b-3p	CLIP-seq
MIRT1143600	hsa-miR-26a	CLIP-seq
MIRT1143601	hsa-miR-26b	CLIP-seq
MIRT1143602	hsa-miR-298	CLIP-seq
MIRT2040888	hsa-miR-3129-5p	CLIP-seq
MIRT2040889	hsa-miR-3148	CLIP-seq
MIRT1143606	hsa-miR-3152-5p	CLIP-seq
MIRT2040890	hsa-miR-3179	CLIP-seq
MIRT2040891	hsa-miR-3202	CLIP-seq
MIRT2040892	hsa-miR-323-3p	CLIP-seq
MIRT1143607	hsa-miR-330-3p	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143609	hsa-miR-3591-3p	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT1143614	hsa-miR-384	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT2040893	hsa-miR-4305	CLIP-seq
MIRT1143619	hsa-miR-4320	CLIP-seq
MIRT1143620	hsa-miR-4422	CLIP-seq
MIRT1143622	hsa-miR-4465	CLIP-seq
MIRT1143623	hsa-miR-4476	CLIP-seq
MIRT2040894	hsa-miR-4646-3p	CLIP-seq
MIRT2040895	hsa-miR-4668-5p	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT2040896	hsa-miR-4727-3p	CLIP-seq
MIRT1143633	hsa-miR-4764-5p	CLIP-seq
MIRT1143634	hsa-miR-4774-3p	CLIP-seq
MIRT2040897	hsa-miR-4775	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT1143645	hsa-miR-665	CLIP-seq
MIRT2040898	hsa-miR-936	CLIP-seq
MIRT2270542	hsa-miR-105	CLIP-seq
MIRT1143588	hsa-miR-1179	CLIP-seq
MIRT1143590	hsa-miR-1243	CLIP-seq
MIRT1143594	hsa-miR-1297	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT1143597	hsa-miR-183	CLIP-seq
MIRT1143599	hsa-miR-224	CLIP-seq
MIRT1143600	hsa-miR-26a	CLIP-seq
MIRT1143601	hsa-miR-26b	CLIP-seq
MIRT1143602	hsa-miR-298	CLIP-seq
MIRT2270543	hsa-miR-3123	CLIP-seq
MIRT1143605	hsa-miR-3129-3p	CLIP-seq
MIRT2040889	hsa-miR-3148	CLIP-seq
MIRT2040890	hsa-miR-3179	CLIP-seq
MIRT2040891	hsa-miR-3202	CLIP-seq
MIRT1143607	hsa-miR-330-3p	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143609	hsa-miR-3591-3p	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT1143614	hsa-miR-384	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT2040893	hsa-miR-4305	CLIP-seq
MIRT1143620	hsa-miR-4422	CLIP-seq
MIRT1143622	hsa-miR-4465	CLIP-seq
MIRT1143623	hsa-miR-4476	CLIP-seq
MIRT2270544	hsa-miR-4662a-5p	CLIP-seq
MIRT2040895	hsa-miR-4668-5p	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT1143631	hsa-miR-4735-5p	CLIP-seq
MIRT1143633	hsa-miR-4764-5p	CLIP-seq
MIRT1143638	hsa-miR-548ag	CLIP-seq
MIRT1143639	hsa-miR-548ai	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143642	hsa-miR-548n	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT1143596	hsa-miR-1323	CLIP-seq
MIRT1143608	hsa-miR-331-5p	CLIP-seq
MIRT1143612	hsa-miR-3675-3p	CLIP-seq
MIRT1143617	hsa-miR-4272	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT1143641	hsa-miR-548l	CLIP-seq
MIRT1143643	hsa-miR-548o	CLIP-seq
MIRT2270542	hsa-miR-105	CLIP-seq
MIRT2569687	hsa-miR-1200	CLIP-seq
MIRT2569688	hsa-miR-1264	CLIP-seq
MIRT1143592	hsa-miR-1269	CLIP-seq
MIRT1143593	hsa-miR-1269b	CLIP-seq
MIRT2569689	hsa-miR-144	CLIP-seq
MIRT2569690	hsa-miR-198	CLIP-seq
MIRT1143599	hsa-miR-224	CLIP-seq
MIRT2569691	hsa-miR-2681	CLIP-seq
MIRT2569692	hsa-miR-29a	CLIP-seq
MIRT2569693	hsa-miR-29b	CLIP-seq
MIRT2569694	hsa-miR-29c	CLIP-seq
MIRT2569695	hsa-miR-3065-5p	CLIP-seq
MIRT1143603	hsa-miR-3119	CLIP-seq
MIRT1143604	hsa-miR-3120-3p	CLIP-seq
MIRT2270543	hsa-miR-3123	CLIP-seq
MIRT2569696	hsa-miR-3124-3p	CLIP-seq
MIRT2569697	hsa-miR-3140-5p	CLIP-seq
MIRT1143606	hsa-miR-3152-5p	CLIP-seq
MIRT2569698	hsa-miR-3194-3p	CLIP-seq
MIRT2569699	hsa-miR-3545-3p	CLIP-seq
MIRT1143610	hsa-miR-3653	CLIP-seq
MIRT1143611	hsa-miR-3658	CLIP-seq
MIRT1143613	hsa-miR-3685	CLIP-seq
MIRT2569700	hsa-miR-3688-5p	CLIP-seq
MIRT2569701	hsa-miR-3919	CLIP-seq
MIRT2569702	hsa-miR-3923	CLIP-seq
MIRT1143615	hsa-miR-409-3p	CLIP-seq
MIRT2569703	hsa-miR-412	CLIP-seq
MIRT1143616	hsa-miR-4271	CLIP-seq
MIRT2569704	hsa-miR-4275	CLIP-seq
MIRT2569705	hsa-miR-4307	CLIP-seq
MIRT1143618	hsa-miR-4310	CLIP-seq
MIRT2569706	hsa-miR-4326	CLIP-seq
MIRT2569707	hsa-miR-4433	CLIP-seq
MIRT2569708	hsa-miR-4459	CLIP-seq
MIRT2569709	hsa-miR-4470	CLIP-seq
MIRT2569710	hsa-miR-4480	CLIP-seq
MIRT2569711	hsa-miR-4490	CLIP-seq
MIRT1143626	hsa-miR-4520b-3p	CLIP-seq
MIRT1143627	hsa-miR-4529-3p	CLIP-seq
MIRT2569712	hsa-miR-4645-3p	CLIP-seq
MIRT2569713	hsa-miR-4645-5p	CLIP-seq
MIRT2569714	hsa-miR-4673	CLIP-seq
MIRT1143628	hsa-miR-4678	CLIP-seq
MIRT2569715	hsa-miR-4724-5p	CLIP-seq
MIRT1143630	hsa-miR-4725-3p	CLIP-seq
MIRT1143632	hsa-miR-4747-5p	CLIP-seq
MIRT2569716	hsa-miR-4768-3p	CLIP-seq
MIRT1143634	hsa-miR-4774-3p	CLIP-seq
MIRT2569717	hsa-miR-4774-5p	CLIP-seq
MIRT2569718	hsa-miR-548m	CLIP-seq
MIRT2569719	hsa-miR-621	CLIP-seq
MIRT2569720	hsa-miR-628-3p	CLIP-seq
MIRT1143644	hsa-miR-649	CLIP-seq
MIRT2270542	hsa-miR-105	CLIP-seq
MIRT2569687	hsa-miR-1200	CLIP-seq
MIRT1143592	hsa-miR-1269	CLIP-seq
MIRT1143593	hsa-miR-1269b	CLIP-seq
MIRT2569689	hsa-miR-144	CLIP-seq
MIRT2569690	hsa-miR-198	CLIP-seq
MIRT2569691	hsa-miR-2681	CLIP-seq
MIRT2569692	hsa-miR-29a	CLIP-seq
MIRT2569693	hsa-miR-29b	CLIP-seq
MIRT2569694	hsa-miR-29c	CLIP-seq
MIRT2569695	hsa-miR-3065-5p	CLIP-seq
MIRT1143603	hsa-miR-3119	CLIP-seq
MIRT2270543	hsa-miR-3123	CLIP-seq
MIRT2569697	hsa-miR-3140-5p	CLIP-seq
MIRT2569698	hsa-miR-3194-3p	CLIP-seq
MIRT2569699	hsa-miR-3545-3p	CLIP-seq
MIRT2569700	hsa-miR-3688-5p	CLIP-seq
MIRT2569701	hsa-miR-3919	CLIP-seq
MIRT2569702	hsa-miR-3923	CLIP-seq
MIRT2569705	hsa-miR-4307	CLIP-seq
MIRT2569709	hsa-miR-4470	CLIP-seq
MIRT2569710	hsa-miR-4480	CLIP-seq
MIRT2569711	hsa-miR-4490	CLIP-seq
MIRT1143626	hsa-miR-4520b-3p	CLIP-seq
MIRT1143627	hsa-miR-4529-3p	CLIP-seq
MIRT2569712	hsa-miR-4645-3p	CLIP-seq
MIRT2569713	hsa-miR-4645-5p	CLIP-seq
MIRT2569714	hsa-miR-4673	CLIP-seq
MIRT2569715	hsa-miR-4724-5p	CLIP-seq
MIRT2569717	hsa-miR-4774-5p	CLIP-seq
MIRT2569718	hsa-miR-548m	CLIP-seq
MIRT2569719	hsa-miR-621	CLIP-seq
MIRT2569720	hsa-miR-628-3p	CLIP-seq
MIRT2684840	hsa-miR-767-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PLAGL2	Activation	17462995

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0004177	Function	Aminopeptidase activity	IBA
GO:0004177	Function	Aminopeptidase activity	IDA	8858118
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0004239	Function	Initiator methionyl aminopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15102683
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006446	Process	Regulation of translational initiation	IDA	8858118
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008235	Function	Metalloexopeptidase activity	IBA
GO:0008235	Function	Metalloexopeptidase activity	IDA	8858118
GO:0016485	Process	Protein processing	IDA	8858118
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IEA

Other IDs

• MIM: 601870
• HGNC: 16672
• e!Ensembl: ENSG00000111142

Protein

• UniProt ID: P50579
• Protein name: Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)
• Protein function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalyt
• PDB: 1B59, 1B6A, 1BN5, 1BOA, 1KQ0, 1KQ9, 1QZY, 1R58, 1R5G, 1R5H, 1YW7, 1YW8, 1YW9, 2ADU, 2EA2, 2EA4, 2GA2, 2OAZ, 5CLS, 5D6E, 5D6F, 5JFR, 5JHU, 5JI6, 5LYW, 5LYX, 6QED, 6QEF, 6QEG, 6QEH, 6QEI, 6QEJ, 7A12, 7A13, 7A14, 7A15, 7A16, 8ONY, 8OXG, 9FPZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00557	Peptidase_M24	167 → 466	Metallopeptidase family M24	Domain

• Sequence:

  MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
  GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
  CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
  KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
  VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
  GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
  YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
  DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

• Sequence length: 478

Pathways

Reactome:

Inactivation, recovery and regulation of the phototransduction cascade