Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10971
Gene name Gene Name - the full gene name approved by the HGNC.
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
YWHAQ
Synonyms (NCBI Gene) Gene synonyms aliases
14-3-3, 1C5, HS1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to th
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001321 hsa-miR-1-3p pSILAC 18668040
MIRT001321 hsa-miR-1-3p Proteomics;Other 18668040
MIRT024964 hsa-miR-214-3p Microarray;Other 19859982
MIRT051526 hsa-let-7e-5p CLASH 23622248
MIRT051373 hsa-let-7f-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
ESR1 Unknown 22329840
PGR Unknown 22329840
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 7760835, 8663231, 9092538, 10954706, 11697890, 14743216, 15094368, 15196694, 15657067, 15660133, 16367866, 16775625, 16868027, 17085597, 17620599, 18045992, 18458160, 19172738, 19289404, 19371722, 19559006, 19640509, 19860830, 20029029, 20600589, 20642453, 20936779, 21988832, 230758
GO:0005737 Component Cytoplasm IDA 15163635
GO:0005739 Component Mitochondrion IEA
GO:0005829 Component Cytosol TAS
GO:0005925 Component Focal adhesion HDA 21423176
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609009 12854 ENSG00000134308
Protein
UniProt ID P27348
Protein name 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally resu
PDB 2BTP , 5IQP , 6BCR , 6BD2 , 6BQT , 6KZG , 6KZH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 9 229 14-3-3 protein Domain
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest
Sequence
Sequence length 245
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell cycle
Oocyte meiosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Hepatitis C
Hepatitis B
Viral carcinogenesis
  Activation of BAD and translocation to mitochondria
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Unknown
Disease term Disease name Evidence References Source
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Akinetic Mutism Associate 21155168
Alcoholism Associate 21332526
Alzheimer Disease Associate 33254518, 37468915
Amyotrophic Lateral Sclerosis Associate 11080204, 30283000
Astrocytoma Associate 23020756, 33469081
Autism Spectrum Disorder Associate 28522826
Brain Diseases Associate 21332526
Brain Ischemia Associate 22558368
Brain Neoplasms Associate 33469081
Breast Neoplasms Associate 23292247