Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10951
Gene name Gene Name - the full gene name approved by the HGNC.
Chromobox 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CBX1
Synonyms (NCBI Gene) Gene synonyms aliases
CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, Hp1beta, M31, MOD1, p25beta
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can b
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003170 hsa-miR-210-3p immunoprecipitaion, Microarray, qRT-PCR 19826008
MIRT003170 hsa-miR-210-3p immunoprecipitaion, Microarray, qRT-PCR 19826008
MIRT016166 hsa-miR-590-3p Sequencing 20371350
MIRT016475 hsa-miR-193b-3p Microarray 20304954
MIRT021150 hsa-miR-186-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000775 Component Chromosome, centromeric region IDA 8287692
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0000781 Component Chromosome, telomeric region IDA 24270157
GO:0000785 Component Chromatin IDA 11101528
GO:0000792 Component Heterochromatin TAS 9169582
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604511 1551 ENSG00000108468
Protein
UniProt ID P83916
Protein name Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Protein function Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear
PDB 2FMM , 3F2U , 3Q6S , 5T1G , 6D07 , 6D08
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00385 Chromo 21 70 Chromo (CHRromatin Organisation MOdifier) domain Domain
PF01393 Chromo_shadow 118 170 Chromo shadow domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all adult and embryonic tissues.
Sequence
MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC
PDLIAEFLQS
QKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPE
RIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTW
HSYPSEDDDK
KDDKN
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HCMV Early Events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17199135
Unknown
Disease term Disease name Evidence References Source
Neurodevelopmental Disorders neurodevelopmental disorder GenCC
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32894652
Adenoma Inhibit 24840329
Arthralgia Inhibit 16476713
ATR X syndrome Associate 39862081
Breast Neoplasms Associate 25769025, 33082469, 33400401
Calcinosis Cutis Associate 24840329
Carcinogenesis Inhibit 17201154
Carcinogenesis Associate 36310139, 37782747
Carcinoma Hepatocellular Associate 30481161
DNA Virus Infections Associate 19783983