Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10951
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Chromobox 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
CBX1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, Hp1beta, M31, MOD1, p25beta |
Chromosome
Chromosome number
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17 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q21.32 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can b |
UniProt ID |
P83916
|
Protein name |
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) |
Protein function |
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear |
PDB |
2FMM
,
3F2U
,
3Q6S
,
5T1G
,
6D07
,
6D08
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00385
|
Chromo |
21 → 70 |
Chromo (CHRromatin Organisation MOdifier) domain |
Domain |
PF01393
|
Chromo_shadow |
118 → 170 |
Chromo shadow domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed in all adult and embryonic tissues. |
Sequence |
|
Sequence length |
185 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17199135 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Neurodevelopmental Disorders |
neurodevelopmental disorder |
|
|
GenCC |
Diabetes |
Diabetes |
|
|
GWAS |
|
|