Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10945
Gene name Gene Name - the full gene name approved by the HGNC.
KDEL endoplasmic reticulum protein retention receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KDELR1
Synonyms (NCBI Gene) Gene synonyms aliases
ERD2, ERD2.1, HDEL, PM23
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-ter
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023631 hsa-miR-1-3p Proteomics 18668040
MIRT027910 hsa-miR-96-5p Sequencing 20371350
MIRT052299 hsa-let-7b-5p CLASH 23622248
MIRT049826 hsa-miR-92a-3p CLASH 23622248
MIRT044760 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 8392934, 18086916
GO:0000139 Component Golgi membrane TAS
GO:0005046 Function KDEL sequence binding IDA 8392934, 18086916
GO:0005515 Function Protein binding IPI 32296183
GO:0005783 Component Endoplasmic reticulum IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
131235 6304 ENSG00000105438
Protein
UniProt ID P24390
Protein name ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23)
Protein function Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. {ECO:0000269|PubMed:11703931, ECO:0000269|PubMed:14
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00810 ER_lumen_recept 28 169 ER lumen protein retaining receptor Family
Sequence
Sequence length 212
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Vibrio cholerae infection   COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Associations from Text Mining
Disease Name Relationship Type References
Carcinogenesis Associate 19457610
Lymphatic Metastasis Associate 39875049
Neoplasms Associate 39875049
Squamous Cell Carcinoma of Head and Neck Associate 39875049