Gene Gene information from NCBI Gene database.
Entrez ID 10935
Gene name Peroxiredoxin 3
Gene symbol PRDX3
Synonyms (NCBI Gene)
AOP-1AOP1HBC189MER5PPPCDPRO1748SCAR32SP-22prx-III
Chromosome 10
Chromosome location 10q26.11
Summary This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C2
miRNA miRNA information provided by mirtarbase database.
594
miRTarBase ID miRNA Experiments Reference
MIRT007305 hsa-miR-383-5p Luciferase reporter assay 23227829
MIRT007305 hsa-miR-383-5p Luciferase reporter assay 23227829
MIRT016299 hsa-miR-193b-3p Proteomics 21512034
MIRT019731 hsa-miR-375 Microarray 20215506
MIRT025072 hsa-miR-181a-5p Microarray 17612493
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
MYC Activation 12011429
NRF1 Activation 21051700
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
51
GO ID Ontology Definition Evidence Reference
GO:0001893 Process Maternal placenta development IEA
GO:0004601 Function Peroxidase activity IEA
GO:0005515 Function Protein binding IPI 12492477, 15750338, 17060495, 18205602, 20873783, 21850687, 24459295, 25416956, 29892012, 31046837, 31515488, 32296183
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IDA 18205602
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604769 9354 ENSG00000165672
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30048
Protein name Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Protein function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMe
PDB 5JCG , 5UCX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00578 AhpC-TSA 65 198 AhpC/TSA family Domain
PF10417 1-cysPrx_C 218 253 C-terminal domain of 1-Cys peroxiredoxin Domain
Sequence
Sequence length 256
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Detoxification of Reactive Oxygen Species
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
17
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autosomal recessive cerebellar ataxia Likely pathogenic; Pathogenic rs371560438 RCV001785420
Corneal dystrophy, punctiform and polychromatic pre-descemet Likely pathogenic; Pathogenic rs371560438, rs2133650052 RCV003989712
RCV002248455
Spinocerebellar ataxia, autosomal recessive 32 Likely pathogenic; Pathogenic rs371560438, rs548327727, rs2133659317, rs140609531, rs1368897658, rs925412397, rs2493973819 RCV003225750
RCV002248450
RCV002248451
RCV002248452
RCV002248454
RCV003152444
RCV003159262
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26810067
Alzheimer Disease Associate 32711556, 37762527
Ataxia Associate 36233161
Autistic Disorder Associate 22051046
Breast Neoplasms Associate 20541551, 29545070
Carcinoma Hepatocellular Associate 24815434, 31215439, 33771165
Carcinoma Ovarian Epithelial Associate 23564483
Carcinoma Renal Cell Associate 23510786, 25093297
Cardiomyopathy Dilated Associate 25397948
Cerebellar Ataxia Associate 37553803