Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10935
Gene name Gene Name - the full gene name approved by the HGNC.
Peroxiredoxin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRDX3
Synonyms (NCBI Gene) Gene synonyms aliases
AOP-1, AOP1, HBC189, MER5, PPPCD, PRO1748, SCAR32, SP-22, prx-III
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PPPCD, SCAR32
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007305 hsa-miR-383-5p Luciferase reporter assay 23227829
MIRT007305 hsa-miR-383-5p Luciferase reporter assay 23227829
MIRT016299 hsa-miR-193b-3p Proteomics 21512034
MIRT019731 hsa-miR-375 Microarray 20215506
MIRT025072 hsa-miR-181a-5p Microarray 17612493
Transcription factors
Transcription factor Regulation Reference
MYC Activation 12011429
NRF1 Activation 21051700
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001893 Process Maternal placenta development IEA
GO:0005515 Function Protein binding IPI 15750338, 21850687, 24459295, 25416956, 29892012, 31046837, 31515488, 32296183
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm IDA 18205602
GO:0005739 Component Mitochondrion IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604769 9354 ENSG00000165672
Protein
UniProt ID P30048
Protein name Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Protein function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMe
PDB 5JCG , 5UCX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00578 AhpC-TSA 65 198 AhpC/TSA family Domain
PF10417 1-cysPrx_C 218 253 C-terminal domain of 1-Cys peroxiredoxin Domain
Sequence
Sequence length 256
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Detoxification of Reactive Oxygen Species
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diffuse lymphoma Diffuse Large B-Cell Lymphoma rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291 16081686
Lateral sclerosis Lateral Sclerosis rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 16702190
Motor neuron disease Motor Neuron Disease, Familial Motor Neuron Disease, Motor Neuron Disease, Lower, Motor Neuron Disease, Upper, Motor Neuron Disease, Secondary rs121912431, rs121912439, rs121912437, rs80356719, rs121912441, rs1131690782, rs1131690775, rs895824243, rs1131690781 16702190
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 18924182
Unknown
Disease term Disease name Evidence References Source
Spinocerebellar Ataxia spinocerebellar ataxia, autosomal recessive 32 GenCC
Corneal Dystrophy corneal dystrophy, punctiform and polychromatic pre-descemet GenCC
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26810067
Alzheimer Disease Associate 32711556, 37762527
Ataxia Associate 36233161
Autistic Disorder Associate 22051046
Breast Neoplasms Associate 20541551, 29545070
Carcinoma Hepatocellular Associate 24815434, 31215439, 33771165
Carcinoma Ovarian Epithelial Associate 23564483
Carcinoma Renal Cell Associate 23510786, 25093297
Cardiomyopathy Dilated Associate 25397948
Cerebellar Ataxia Associate 37553803