Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10922
Gene name Gene Name - the full gene name approved by the HGNC.	Fas activated serine/threonine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FASTK
Synonyms (NCBI Gene) Gene synonyms aliases	FAST
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q36.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apopt

Show/Hide all(95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045322	hsa-miR-185-5p	CLASH	23622248
MIRT043485	hsa-miR-331-3p	CLASH	23622248
MIRT054367	hsa-miR-106a-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24013584
MIRT486250	hsa-miR-3141	PAR-CLIP	23592263
MIRT486251	hsa-miR-134-3p	PAR-CLIP	23592263
MIRT486249	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT486248	hsa-miR-4784	PAR-CLIP	23592263
MIRT486247	hsa-miR-657	PAR-CLIP	23592263
MIRT486246	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT486245	hsa-miR-4736	PAR-CLIP	23592263
MIRT486244	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT486243	hsa-miR-8085	PAR-CLIP	23592263
MIRT486242	hsa-miR-3175	PAR-CLIP	23592263
MIRT486241	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT486240	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT486239	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT486238	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT486237	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT486235	hsa-miR-4447	PAR-CLIP	23592263
MIRT486236	hsa-miR-4472	PAR-CLIP	23592263
MIRT486234	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT486233	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT486232	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT486231	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT486250	hsa-miR-3141	PAR-CLIP	23592263
MIRT486251	hsa-miR-134-3p	PAR-CLIP	23592263
MIRT486249	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT486248	hsa-miR-4784	PAR-CLIP	23592263
MIRT486247	hsa-miR-657	PAR-CLIP	23592263
MIRT486246	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT486245	hsa-miR-4736	PAR-CLIP	23592263
MIRT486244	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT486243	hsa-miR-8085	PAR-CLIP	23592263
MIRT486242	hsa-miR-3175	PAR-CLIP	23592263
MIRT486241	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT486240	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT486239	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT486238	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT486237	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT486235	hsa-miR-4447	PAR-CLIP	23592263
MIRT486236	hsa-miR-4472	PAR-CLIP	23592263
MIRT486234	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT486233	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT486232	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT486231	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT989618	hsa-miR-106a	CLIP-seq
MIRT989619	hsa-miR-106b	CLIP-seq
MIRT989620	hsa-miR-130a	CLIP-seq
MIRT989621	hsa-miR-130b	CLIP-seq
MIRT989622	hsa-miR-1323	CLIP-seq
MIRT989623	hsa-miR-17	CLIP-seq
MIRT989624	hsa-miR-19a	CLIP-seq
MIRT989625	hsa-miR-19b	CLIP-seq
MIRT989626	hsa-miR-20a	CLIP-seq
MIRT989627	hsa-miR-20b	CLIP-seq
MIRT989628	hsa-miR-301a	CLIP-seq
MIRT989629	hsa-miR-301b	CLIP-seq
MIRT989630	hsa-miR-3666	CLIP-seq
MIRT989631	hsa-miR-4295	CLIP-seq
MIRT989632	hsa-miR-454	CLIP-seq
MIRT989633	hsa-miR-519a	CLIP-seq
MIRT989634	hsa-miR-519b-3p	CLIP-seq
MIRT989635	hsa-miR-519c-3p	CLIP-seq
MIRT989636	hsa-miR-519d	CLIP-seq
MIRT989637	hsa-miR-520g	CLIP-seq
MIRT989638	hsa-miR-520h	CLIP-seq
MIRT989639	hsa-miR-548o	CLIP-seq
MIRT989640	hsa-miR-93	CLIP-seq
MIRT989618	hsa-miR-106a	CLIP-seq
MIRT989619	hsa-miR-106b	CLIP-seq
MIRT989620	hsa-miR-130a	CLIP-seq
MIRT989621	hsa-miR-130b	CLIP-seq
MIRT989622	hsa-miR-1323	CLIP-seq
MIRT989623	hsa-miR-17	CLIP-seq
MIRT989624	hsa-miR-19a	CLIP-seq
MIRT989625	hsa-miR-19b	CLIP-seq
MIRT989626	hsa-miR-20a	CLIP-seq
MIRT989627	hsa-miR-20b	CLIP-seq
MIRT989628	hsa-miR-301a	CLIP-seq
MIRT989629	hsa-miR-301b	CLIP-seq
MIRT2227122	hsa-miR-3140-5p	CLIP-seq
MIRT989630	hsa-miR-3666	CLIP-seq
MIRT989631	hsa-miR-4295	CLIP-seq
MIRT2227123	hsa-miR-4529-5p	CLIP-seq
MIRT989632	hsa-miR-454	CLIP-seq
MIRT2227124	hsa-miR-4793-5p	CLIP-seq
MIRT989633	hsa-miR-519a	CLIP-seq
MIRT989634	hsa-miR-519b-3p	CLIP-seq
MIRT989635	hsa-miR-519c-3p	CLIP-seq
MIRT989636	hsa-miR-519d	CLIP-seq
MIRT989637	hsa-miR-520g	CLIP-seq
MIRT989638	hsa-miR-520h	CLIP-seq
MIRT2227125	hsa-miR-539	CLIP-seq
MIRT989639	hsa-miR-548o	CLIP-seq
MIRT989640	hsa-miR-93	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	7544399
GO:0005515	Function	Protein binding	IPI	7544399, 15110758, 25416956, 25910212, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0006468	Process	Protein phosphorylation	IDA	7544399
GO:0033867	Function	Fas-activated serine/threonine kinase activity	IEA
GO:0043484	Process	Regulation of RNA splicing	IDA	17135269
GO:0043484	Process	Regulation of RNA splicing	IMP	17592127
GO:0044528	Process	Regulation of mitochondrial mRNA stability	IEA
GO:0097190	Process	Apoptotic signaling pathway	TAS	7544399

MIM	HGNC	e!Ensembl
606965	24676	ENSG00000164896

Protein

UniProt ID

Q14296

Protein name

Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8)

Protein function

Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. ; [Isoform 4]: R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06743	FAST_1	278 → 344	FAST kinase-like protein, subdomain 1	Family
PF08368	FAST_2	355 → 444	FAST kinase-like protein, subdomain 2	Family
PF08373	RAP	481 → 536	RAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Sequence

MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP
CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR
LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL
EQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVM
VLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCL
ERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSL
LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQ
DLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLV
LRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQAL
GLRWGPEGG

Sequence length

549

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma	Associate	12865273
Astrocytoma	Associate	24013584
Dermatitis Atopic 1	Associate	11207646
Leukemia Myeloid Acute	Associate	23161387
Mitochondrial Encephalomyopathies	Associate	26370583
Mycosis Fungoides	Associate	18832135
Neoplasms	Associate	34768773
Ovarian Neoplasms	Associate	34768773
Retinal Dysplasia	Associate	12865273
Stomach Neoplasms	Stimulate	34768773

FASTK (Fas activated serine/threonine kinase)