Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	10922
Gene name	Fas activated serine/threonine kinase
Gene symbol	FASTK
Synonyms (NCBI Gene)	FAST
Chromosome	7
Chromosome location	7q36.1
Summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apopt

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miRTarBase ID	miRNA	Experiments	Reference
MIRT045322	hsa-miR-185-5p	CLASH	23622248
MIRT043485	hsa-miR-331-3p	CLASH	23622248
MIRT054367	hsa-miR-106a-5p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	24013584
MIRT486250	hsa-miR-3141	PAR-CLIP	23592263
MIRT486251	hsa-miR-134-3p	PAR-CLIP	23592263
MIRT486249	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT486248	hsa-miR-4784	PAR-CLIP	23592263
MIRT486247	hsa-miR-657	PAR-CLIP	23592263
MIRT486246	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT486245	hsa-miR-4736	PAR-CLIP	23592263
MIRT486244	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT486243	hsa-miR-8085	PAR-CLIP	23592263
MIRT486242	hsa-miR-3175	PAR-CLIP	23592263
MIRT486241	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT486240	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT486239	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT486238	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT486237	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT486235	hsa-miR-4447	PAR-CLIP	23592263
MIRT486236	hsa-miR-4472	PAR-CLIP	23592263
MIRT486234	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT486233	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT486232	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT486231	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT486250	hsa-miR-3141	PAR-CLIP	23592263
MIRT486251	hsa-miR-134-3p	PAR-CLIP	23592263
MIRT486249	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT486248	hsa-miR-4784	PAR-CLIP	23592263
MIRT486247	hsa-miR-657	PAR-CLIP	23592263
MIRT486246	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT486245	hsa-miR-4736	PAR-CLIP	23592263
MIRT486244	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT486243	hsa-miR-8085	PAR-CLIP	23592263
MIRT486242	hsa-miR-3175	PAR-CLIP	23592263
MIRT486241	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT486240	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT486239	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT486238	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT486237	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT486235	hsa-miR-4447	PAR-CLIP	23592263
MIRT486236	hsa-miR-4472	PAR-CLIP	23592263
MIRT486234	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT486233	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT486232	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT486231	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT989618	hsa-miR-106a	CLIP-seq
MIRT989619	hsa-miR-106b	CLIP-seq
MIRT989620	hsa-miR-130a	CLIP-seq
MIRT989621	hsa-miR-130b	CLIP-seq
MIRT989622	hsa-miR-1323	CLIP-seq
MIRT989623	hsa-miR-17	CLIP-seq
MIRT989624	hsa-miR-19a	CLIP-seq
MIRT989625	hsa-miR-19b	CLIP-seq
MIRT989626	hsa-miR-20a	CLIP-seq
MIRT989627	hsa-miR-20b	CLIP-seq
MIRT989628	hsa-miR-301a	CLIP-seq
MIRT989629	hsa-miR-301b	CLIP-seq
MIRT989630	hsa-miR-3666	CLIP-seq
MIRT989631	hsa-miR-4295	CLIP-seq
MIRT989632	hsa-miR-454	CLIP-seq
MIRT989633	hsa-miR-519a	CLIP-seq
MIRT989634	hsa-miR-519b-3p	CLIP-seq
MIRT989635	hsa-miR-519c-3p	CLIP-seq
MIRT989636	hsa-miR-519d	CLIP-seq
MIRT989637	hsa-miR-520g	CLIP-seq
MIRT989638	hsa-miR-520h	CLIP-seq
MIRT989639	hsa-miR-548o	CLIP-seq
MIRT989640	hsa-miR-93	CLIP-seq
MIRT989618	hsa-miR-106a	CLIP-seq
MIRT989619	hsa-miR-106b	CLIP-seq
MIRT989620	hsa-miR-130a	CLIP-seq
MIRT989621	hsa-miR-130b	CLIP-seq
MIRT989622	hsa-miR-1323	CLIP-seq
MIRT989623	hsa-miR-17	CLIP-seq
MIRT989624	hsa-miR-19a	CLIP-seq
MIRT989625	hsa-miR-19b	CLIP-seq
MIRT989626	hsa-miR-20a	CLIP-seq
MIRT989627	hsa-miR-20b	CLIP-seq
MIRT989628	hsa-miR-301a	CLIP-seq
MIRT989629	hsa-miR-301b	CLIP-seq
MIRT2227122	hsa-miR-3140-5p	CLIP-seq
MIRT989630	hsa-miR-3666	CLIP-seq
MIRT989631	hsa-miR-4295	CLIP-seq
MIRT2227123	hsa-miR-4529-5p	CLIP-seq
MIRT989632	hsa-miR-454	CLIP-seq
MIRT2227124	hsa-miR-4793-5p	CLIP-seq
MIRT989633	hsa-miR-519a	CLIP-seq
MIRT989634	hsa-miR-519b-3p	CLIP-seq
MIRT989635	hsa-miR-519c-3p	CLIP-seq
MIRT989636	hsa-miR-519d	CLIP-seq
MIRT989637	hsa-miR-520g	CLIP-seq
MIRT989638	hsa-miR-520h	CLIP-seq
MIRT2227125	hsa-miR-539	CLIP-seq
MIRT989639	hsa-miR-548o	CLIP-seq
MIRT989640	hsa-miR-93	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000963	Process	Mitochondrial RNA processing	IBA
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	7544399
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	7544399, 15110758, 17135269, 25416956, 25910212, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IBA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006468	Process	Protein phosphorylation	IDA	7544399
GO:0006915	Process	Apoptotic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0033867	Function	Fas-activated serine/threonine kinase activity	IEA
GO:0035770	Component	Ribonucleoprotein granule	IBA
GO:0043484	Process	Regulation of RNA splicing	IDA	17135269
GO:0043484	Process	Regulation of RNA splicing	IMP	17592127
GO:0044528	Process	Regulation of mitochondrial mRNA stability	IBA
GO:0044528	Process	Regulation of mitochondrial mRNA stability	IEA
GO:0097190	Process	Apoptotic signaling pathway	TAS	7544399
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
606965	24676	ENSG00000164896

Q14296

Protein name

Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8)

Protein function

Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. ; [Isoform 4]: R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06743	FAST_1	278 → 344	FAST kinase-like protein, subdomain 1	Family
PF08368	FAST_2	355 → 444	FAST kinase-like protein, subdomain 2	Family
PF08373	RAP	481 → 536	RAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Sequence

MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP
CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR
LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL
EQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVM
VLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCL
ERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSL
LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQ
DLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLV
LRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQAL
GLRWGPEGG

Sequence length

549

Interactions

View interactions

FASTK (Fas activated serine/threonine kinase)