Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10921
Gene name Gene Name - the full gene name approved by the HGNC.
RNA binding protein with serine rich domain 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNPS1
Synonyms (NCBI Gene) Gene synonyms aliases
E5.1
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA d
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049704 hsa-miR-92a-3p CLASH 23622248
MIRT047858 hsa-miR-30c-5p CLASH 23622248
MIRT045589 hsa-miR-149-5p CLASH 23622248
MIRT044270 hsa-miR-106b-5p CLASH 23622248
MIRT043958 hsa-miR-378a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA 11546874
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 16209946
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IMP 22203037
GO:0000398 Process MRNA splicing, via spliceosome IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606447 10080 ENSG00000205937
Protein
UniProt ID Q15287
Protein name RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Protein function Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins
PDB 4A8X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 163 234 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:8543184}.
Sequence
MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRD
KTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSS
SGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEI
FSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEIT
ATAVLA
PWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSS
SNSSR
Sequence length 305
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleocytoplasmic transport
mRNA surveillance pathway
  Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Carcinogenesis Associate 36300671
Carcinoma Squamous Cell Associate 27990632
Carcinoma Squamous Cell Stimulate 36300671
Endometrial Neoplasms Associate 31355251, 34817046
Neoplasm Metastasis Associate 36300671
Neoplasms Associate 34817046, 36300671, 38246918
Poisoning Associate 33176162
Squamous Cell Carcinoma of Head and Neck Associate 38246918
Uterine Cervical Neoplasms Associate 36300671