PAPOLA (poly(A) polymerase alpha)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10914 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Poly(A) polymerase alpha |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PAPOLA |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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PAP, PAP-alpha |
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Chromosome
Chromosome number
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14 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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14q32.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3`-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have b |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | P51003 | ||||||||||||||||||||
| Protein name | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | ||||||||||||||||||||
| Protein function | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor | ||||||||||||||||||||
| PDB | 8R8R | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 745 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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