Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10914
Gene name Gene Name - the full gene name approved by the HGNC.
Poly(A) polymerase alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PAPOLA
Synonyms (NCBI Gene) Gene synonyms aliases
PAP, PAP-alpha
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3`-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have b
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs483352759 A>G Conflicting-interpretations-of-pathogenicity Synonymous variant, coding sequence variant, genic downstream transcript variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005093 hsa-miR-155-5p Microarray 19193853
MIRT020257 hsa-miR-130b-3p Sequencing 20371350
MIRT028127 hsa-miR-93-5p Sequencing 20371350
MIRT052114 hsa-let-7b-5p CLASH 23622248
MIRT052114 hsa-let-7b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding ISS
GO:0000398 Process MRNA splicing, via spliceosome TAS
GO:0003723 Function RNA binding IEA
GO:0004652 Function Polynucleotide adenylyltransferase activity IBA 21873635
GO:0004652 Function Polynucleotide adenylyltransferase activity IDA 7590244
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605553 14981 ENSG00000090060
Protein
UniProt ID P51003
Protein name Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha)
Protein function Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor
PDB 8R8R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04928 PAP_central 21 364 Poly(A) polymerase central domain Domain
PF01909 NTP_transf_2 79 175 Nucleotidyltransferase domain Family
PF04926 PAP_RNA-bind 366 435 Poly(A) polymerase predicted RNA binding domain Domain
Sequence
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
RILILGKLNNLVKEWIRE
ISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLAL
QTIPE
DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
LFEA
PNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
FPAPKENPDKEEFRT
MWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
LSDIPALPANPIPVIKNSIKLRLNR
Sequence length 745
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mRNA surveillance pathway   mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 19503088
Unknown
Disease term Disease name Evidence References Source
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Bacteriuria Associate 17065267
Calcinosis Cutis Associate 33903734
Chromosome Deletion Associate 32917334
Cognition Disorders Associate 33725412
Cystic Fibrosis Associate 24513262, 34764021
Genetic Diseases Inborn Associate 32917334
Heat Stress Disorders Associate 25280538
Liver Failure Associate 25280538
Meconium Ileus Associate 34764021
Neoplasm Metastasis Associate 9356495