SLC22A7 (solute carrier family 22 member 7)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10864
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 22 member 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC22A7
Synonyms (NCBI Gene) Gene synonyms aliases
NLT, OAT2, hOAT11
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membr
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(14)
miRTarBase ID miRNA Experiments Reference
MIRT1354593 hsa-miR-3157-5p CLIP-seq
MIRT1354594 hsa-miR-4452 CLIP-seq
MIRT1354595 hsa-miR-4474-3p CLIP-seq
MIRT2104949 hsa-miR-4685-5p CLIP-seq
MIRT2623871 hsa-miR-1915 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15846844
GO:0005886 Component Plasma membrane IDA 28112518
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 9650585
GO:0015347 Function Sodium-independent organic anion transmembrane transporter activity TAS 9650585
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604995 10971 ENSG00000137204
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9Y694
Protein name Solute carrier family 22 member 7 (Novel liver transporter) (NLT) (Organic anion transporter 2) (hOAT2)
Protein function [Isoform 2]: Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:11327718, PubMed:18216183, PubMed:21446918, PubMed:28945155). Contributes to the renal and hepatic elimination of endogenous organic compounds from the
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07690 MFS_1 75 → 481 Major Facilitator Superfamily Family
Tissue specificity TISSUE SPECIFICITY: Mainly expressed in liver and kidney (PubMed:11327718, PubMed:18216183, PubMed:21446918, PubMed:25904762). In kidney, expressed in proximal tubular cells (PubMed:25904762). Also expressed in pancreas, small intestine, spinal cord, lung
Sequence
Sequence length 548
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Bile secretion   Organic anion transport
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Hypertension Hypertensive disease rs13306026 30487518
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Ischemic Stroke Ischemic Stroke GWAS
Diabetes Diabetes GWAS
Show/Hide Text Mining Associations (5)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Inhibit 32461965
Carcinoma Renal Cell Associate 37657024
Colorectal Neoplasms Associate 34599518
Neoplasms Associate 34132895
Neoplasms Inhibit 35510337