ADAM28 (ADAM metallopeptidase domain 28)

Gene

• Entrez ID: 10863
• Gene name: ADAM metallopeptidase domain 28
• Gene symbol: ADAM28
• Synonyms (NCBI Gene): ADAM 28, MDC-L, MDCL, eMDC II, eMDCII
• Chromosome: 8
• Chromosome location: 8p21.2
• Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT531705	hsa-miR-3914	PAR-CLIP	22012620
MIRT531704	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT531703	hsa-miR-3913-3p	PAR-CLIP	22012620
MIRT531702	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT531701	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT531700	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT531699	hsa-miR-23c	PAR-CLIP	22012620
MIRT531698	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT531697	hsa-miR-6511b-5p	PAR-CLIP	22012620
MIRT531696	hsa-miR-6811-5p	PAR-CLIP	22012620
MIRT531695	hsa-miR-651-5p	PAR-CLIP	22012620
MIRT531705	hsa-miR-3914	PAR-CLIP	22012620
MIRT531704	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT531703	hsa-miR-3913-3p	PAR-CLIP	22012620
MIRT531702	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT531701	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT531700	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT531699	hsa-miR-23c	PAR-CLIP	22012620
MIRT531698	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT531697	hsa-miR-6511b-5p	PAR-CLIP	22012620
MIRT531696	hsa-miR-6811-5p	PAR-CLIP	22012620
MIRT531695	hsa-miR-651-5p	PAR-CLIP	22012620
MIRT766144	hsa-miR-329	CLIP-seq
MIRT766145	hsa-miR-362-3p	CLIP-seq
MIRT766146	hsa-miR-4762-5p	CLIP-seq
MIRT766147	hsa-miR-548aa	CLIP-seq
MIRT1925769	hsa-miR-3942-3p	CLIP-seq
MIRT1925770	hsa-miR-4452	CLIP-seq
MIRT1925771	hsa-miR-4775	CLIP-seq
MIRT766144	hsa-miR-329	CLIP-seq
MIRT766145	hsa-miR-362-3p	CLIP-seq
MIRT766144	hsa-miR-329	CLIP-seq
MIRT766145	hsa-miR-362-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007283	Process	Spermatogenesis	TAS	10587367
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IDA	12777399
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	10587367
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0034987	Function	Immunoglobulin receptor binding	IPI	12777399
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 606188
• HGNC: 206
• e!Ensembl: ENSG00000042980

Protein

• UniProt ID: Q9UKQ2
• Protein name: Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (M
• Protein function: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	29 → 156	Reprolysin family propeptide	Family
  PF01421	Reprolysin	204 → 399	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF00200	Disintegrin	416 → 488	Disintegrin	Domain
  PF08516	ADAM_CR	493 → 591	ADAM cysteine-rich	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform
• Sequence:

  MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK
  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS
  ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL
  QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM
  LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE
  LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI
  CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED
  CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG
  KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSK
  YGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMV
  ANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSS
  VVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVK
  AVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA

• Sequence length: 775

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Hereditary spastic paraplegia	Affects	rs201643797	RCV001376690

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	22514692
Colorectal Neoplasms	Associate	23527725, 30840270
Diabetes Mellitus Type 2	Associate	23010875
Inflammation	Associate	23010875
Leukemia Lymphocytic Chronic B Cell	Associate	27111430
Lymphoma	Associate	34166375
Metabolic Syndrome	Associate	23010875
Multiple Myeloma	Associate	40665393
Neoplasms	Associate	23527725, 27462861, 27749584, 31602160
Neoplasms	Stimulate	29776401
Obesity	Associate	23010875, 23527725
Overweight	Associate	23527725
Pancreatic Neoplasms	Associate	31602160
Periodontitis	Associate	36927684
Prostatic Neoplasms	Associate	27749584
Prostatitis	Associate	27749584