FRS2 (fibroblast growth factor receptor substrate 2)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10818 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Fibroblast growth factor receptor substrate 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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FRS2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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FRS1A, FRS2A, FRS2alpha, SNT, SNT-1, SNT1 |
Chromosome
Chromosome number
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12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q15 |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q8WU20 | ||||||||||
Protein name | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | ||||||||||
Protein function | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, | ||||||||||
PDB | 1XR0 , 2MFQ | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269|PubMed:10092678}. | ||||||||||
Sequence |
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Sequence length | 508 | ||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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