Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10808
Gene name	Heat shock protein family H (Hsp110) member 1
Gene symbol	HSPH1
Synonyms (NCBI Gene)	HSP105HSP105AHSP105BNY-CO-25
Chromosome	13
Chromosome location	13q12.3
Summary	This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031808	hsa-miR-16-5p	Proteomics	18668040
MIRT049463	hsa-miR-92a-3p	CLASH	23622248
MIRT048010	hsa-miR-30c-5p	CLASH	23622248
MIRT041390	hsa-miR-193b-3p	CLASH	23622248
MIRT1057039	hsa-miR-105	CLIP-seq
MIRT1057040	hsa-miR-1183	CLIP-seq
MIRT1057041	hsa-miR-1207-5p	CLIP-seq
MIRT1057042	hsa-miR-183	CLIP-seq
MIRT1057043	hsa-miR-185	CLIP-seq
MIRT1057044	hsa-miR-223	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT1057048	hsa-miR-3174	CLIP-seq
MIRT1057049	hsa-miR-3200-3p	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057052	hsa-miR-34b	CLIP-seq
MIRT1057053	hsa-miR-3668	CLIP-seq
MIRT1057054	hsa-miR-3672	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057057	hsa-miR-3924	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT1057059	hsa-miR-4306	CLIP-seq
MIRT1057060	hsa-miR-4328	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057062	hsa-miR-4474-5p	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT1057064	hsa-miR-4635	CLIP-seq
MIRT1057065	hsa-miR-4643	CLIP-seq
MIRT1057066	hsa-miR-4644	CLIP-seq
MIRT1057067	hsa-miR-4659a-3p	CLIP-seq
MIRT1057068	hsa-miR-4659b-3p	CLIP-seq
MIRT1057069	hsa-miR-4687-5p	CLIP-seq
MIRT1057070	hsa-miR-4696	CLIP-seq
MIRT1057071	hsa-miR-4698	CLIP-seq
MIRT1057072	hsa-miR-4710	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT1057074	hsa-miR-4728-3p	CLIP-seq
MIRT1057075	hsa-miR-4732-5p	CLIP-seq
MIRT1057076	hsa-miR-4736	CLIP-seq
MIRT1057077	hsa-miR-4763-3p	CLIP-seq
MIRT1057078	hsa-miR-4790-3p	CLIP-seq
MIRT1057079	hsa-miR-4792	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT1057082	hsa-miR-515-5p	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057084	hsa-miR-548p	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT1057086	hsa-miR-561	CLIP-seq
MIRT1057087	hsa-miR-567	CLIP-seq
MIRT1057088	hsa-miR-582-5p	CLIP-seq
MIRT1057089	hsa-miR-873	CLIP-seq
MIRT1057090	hsa-miR-921	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057053	hsa-miR-3668	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057057	hsa-miR-3924	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057062	hsa-miR-4474-5p	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT1057075	hsa-miR-4732-5p	CLIP-seq
MIRT2013035	hsa-miR-4766-5p	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT1057087	hsa-miR-567	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT1057042	hsa-miR-183	CLIP-seq
MIRT1057043	hsa-miR-185	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057053	hsa-miR-3668	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT2245346	hsa-miR-375	CLIP-seq
MIRT1057057	hsa-miR-3924	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT2245347	hsa-miR-4273	CLIP-seq
MIRT1057059	hsa-miR-4306	CLIP-seq
MIRT1057060	hsa-miR-4328	CLIP-seq
MIRT2245348	hsa-miR-4470	CLIP-seq
MIRT2245349	hsa-miR-4477a	CLIP-seq
MIRT1057065	hsa-miR-4643	CLIP-seq
MIRT1057066	hsa-miR-4644	CLIP-seq
MIRT2245350	hsa-miR-4677-5p	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT1057074	hsa-miR-4728-3p	CLIP-seq
MIRT1057075	hsa-miR-4732-5p	CLIP-seq
MIRT1057078	hsa-miR-4790-3p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT1057082	hsa-miR-515-5p	CLIP-seq
MIRT2245351	hsa-miR-544	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT1057086	hsa-miR-561	CLIP-seq
MIRT1057088	hsa-miR-582-5p	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT1057040	hsa-miR-1183	CLIP-seq
MIRT2548516	hsa-miR-129-3p	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT2548517	hsa-miR-3140-3p	CLIP-seq
MIRT2548518	hsa-miR-320a	CLIP-seq
MIRT2548519	hsa-miR-320b	CLIP-seq
MIRT2548520	hsa-miR-320c	CLIP-seq
MIRT2548521	hsa-miR-320d	CLIP-seq
MIRT2548522	hsa-miR-330-3p	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT2548523	hsa-miR-432	CLIP-seq
MIRT2548524	hsa-miR-4426	CLIP-seq
MIRT2548525	hsa-miR-4429	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057062	hsa-miR-4474-5p	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT2548526	hsa-miR-4520a-3p	CLIP-seq
MIRT2548527	hsa-miR-4520b-3p	CLIP-seq
MIRT2548528	hsa-miR-4647	CLIP-seq
MIRT1057067	hsa-miR-4659a-3p	CLIP-seq
MIRT1057068	hsa-miR-4659b-3p	CLIP-seq
MIRT2548529	hsa-miR-4661-5p	CLIP-seq
MIRT2548530	hsa-miR-4662b	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT2548531	hsa-miR-4753-3p	CLIP-seq
MIRT2548532	hsa-miR-4768-5p	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT2548533	hsa-miR-522	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057084	hsa-miR-548p	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT2548534	hsa-miR-889	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT2548535	hsa-miR-938	CLIP-seq
MIRT1057040	hsa-miR-1183	CLIP-seq
MIRT2548516	hsa-miR-129-3p	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT2548517	hsa-miR-3140-3p	CLIP-seq
MIRT2548518	hsa-miR-320a	CLIP-seq
MIRT2548519	hsa-miR-320b	CLIP-seq
MIRT2548520	hsa-miR-320c	CLIP-seq
MIRT2548521	hsa-miR-320d	CLIP-seq
MIRT2548522	hsa-miR-330-3p	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT2548523	hsa-miR-432	CLIP-seq
MIRT2548524	hsa-miR-4426	CLIP-seq
MIRT2548525	hsa-miR-4429	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT2548526	hsa-miR-4520a-3p	CLIP-seq
MIRT2548527	hsa-miR-4520b-3p	CLIP-seq
MIRT2548528	hsa-miR-4647	CLIP-seq
MIRT1057067	hsa-miR-4659a-3p	CLIP-seq
MIRT1057068	hsa-miR-4659b-3p	CLIP-seq
MIRT2548529	hsa-miR-4661-5p	CLIP-seq
MIRT2548530	hsa-miR-4662b	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT2548531	hsa-miR-4753-3p	CLIP-seq
MIRT2548532	hsa-miR-4768-5p	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT2548533	hsa-miR-522	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057084	hsa-miR-548p	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT2548534	hsa-miR-889	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT2548535	hsa-miR-938	CLIP-seq

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Transcription factor	Regulation	Reference
FOS	Activation	20188076

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000774	Function	Adenyl-nucleotide exchange factor activity	IBA
GO:0000774	Function	Adenyl-nucleotide exchange factor activity	IDA	24318877
GO:0005515	Function	Protein binding	IPI	17024176, 23349634, 24318877, 25036637
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	12952910
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	9931472
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	21231916
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006986	Process	Response to unfolded protein	IEA
GO:0006986	Process	Response to unfolded protein	TAS	9931472
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0043014	Function	Alpha-tubulin binding	IEA
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	IEA
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	TAS	12952910
GO:0051135	Process	Positive regulation of NK T cell activation	IEA
GO:0051135	Process	Positive regulation of NK T cell activation	TAS	12952910
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071682	Component	Endocytic vesicle lumen	TAS
GO:0140662	Function	ATP-dependent protein folding chaperone	IEA

MIM	HGNC	e!Ensembl
610703	16969	ENSG00000120694

Q92598

Protein name

Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1)

Protein function

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins

PDB

6GFA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00012	HSP70	3 → 708	Hsp70 protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. {ECO:0000269|PubMed:10865058, ECO:0000269|PubMed:16232202}.

Sequence

MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHA
NNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAM
LLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALN
YGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKL
VEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGK
MNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGK
DISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVF
SRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKV
KVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGT
QPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEA
NLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQ
DHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELG
QRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVV
RAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPH
QNGECYPNEKNSVNMDLD

Sequence length

858

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum		Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Uncertain significance	rs200964846	RCV005926971
Thyroid cancer, nonmedullary, 1	Benign	rs181708109	RCV005905156

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	25645927, 37338518, 39550832
Carcinoma Squamous Cell	Associate	32991423
Coronary Artery Disease	Associate	28980286
Depressive Disorder Major	Associate	36672180
Diabetes Mellitus	Associate	35855056
Esophagitis	Associate	22901192
Glycogen Storage Disease Type II	Associate	32407518
Hutchinson's Melanotic Freckle	Stimulate	34618840
Macular Degeneration	Associate	30389371
Melanoma	Associate	25645927
Melanoma	Stimulate	34618840
Melanoma Cutaneous Malignant	Associate	34618840
Multiple Sclerosis	Associate	32503176
Neoplasms	Associate	25645927, 25798051
Retinal Drusen	Associate	32407518
Squamous Cell Carcinoma of Head and Neck	Associate	21196872
Tuberculosis Pulmonary	Associate	36787336

HSPH1 (heat shock protein family H (Hsp110) member 1)