Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10808
Gene name Gene Name - the full gene name approved by the HGNC.	Heat shock protein family H (Hsp110) member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HSPH1
Synonyms (NCBI Gene) Gene synonyms aliases	HSP105, HSP105A, HSP105B, NY-CO-25
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q12.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031808	hsa-miR-16-5p	Proteomics	18668040
MIRT049463	hsa-miR-92a-3p	CLASH	23622248
MIRT048010	hsa-miR-30c-5p	CLASH	23622248
MIRT041390	hsa-miR-193b-3p	CLASH	23622248
MIRT1057039	hsa-miR-105	CLIP-seq
MIRT1057040	hsa-miR-1183	CLIP-seq
MIRT1057041	hsa-miR-1207-5p	CLIP-seq
MIRT1057042	hsa-miR-183	CLIP-seq
MIRT1057043	hsa-miR-185	CLIP-seq
MIRT1057044	hsa-miR-223	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT1057048	hsa-miR-3174	CLIP-seq
MIRT1057049	hsa-miR-3200-3p	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057052	hsa-miR-34b	CLIP-seq
MIRT1057053	hsa-miR-3668	CLIP-seq
MIRT1057054	hsa-miR-3672	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057057	hsa-miR-3924	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT1057059	hsa-miR-4306	CLIP-seq
MIRT1057060	hsa-miR-4328	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057062	hsa-miR-4474-5p	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT1057064	hsa-miR-4635	CLIP-seq
MIRT1057065	hsa-miR-4643	CLIP-seq
MIRT1057066	hsa-miR-4644	CLIP-seq
MIRT1057067	hsa-miR-4659a-3p	CLIP-seq
MIRT1057068	hsa-miR-4659b-3p	CLIP-seq
MIRT1057069	hsa-miR-4687-5p	CLIP-seq
MIRT1057070	hsa-miR-4696	CLIP-seq
MIRT1057071	hsa-miR-4698	CLIP-seq
MIRT1057072	hsa-miR-4710	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT1057074	hsa-miR-4728-3p	CLIP-seq
MIRT1057075	hsa-miR-4732-5p	CLIP-seq
MIRT1057076	hsa-miR-4736	CLIP-seq
MIRT1057077	hsa-miR-4763-3p	CLIP-seq
MIRT1057078	hsa-miR-4790-3p	CLIP-seq
MIRT1057079	hsa-miR-4792	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT1057082	hsa-miR-515-5p	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057084	hsa-miR-548p	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT1057086	hsa-miR-561	CLIP-seq
MIRT1057087	hsa-miR-567	CLIP-seq
MIRT1057088	hsa-miR-582-5p	CLIP-seq
MIRT1057089	hsa-miR-873	CLIP-seq
MIRT1057090	hsa-miR-921	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057053	hsa-miR-3668	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057057	hsa-miR-3924	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057062	hsa-miR-4474-5p	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT1057075	hsa-miR-4732-5p	CLIP-seq
MIRT2013035	hsa-miR-4766-5p	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT1057087	hsa-miR-567	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT1057042	hsa-miR-183	CLIP-seq
MIRT1057043	hsa-miR-185	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057053	hsa-miR-3668	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT2245346	hsa-miR-375	CLIP-seq
MIRT1057057	hsa-miR-3924	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT2245347	hsa-miR-4273	CLIP-seq
MIRT1057059	hsa-miR-4306	CLIP-seq
MIRT1057060	hsa-miR-4328	CLIP-seq
MIRT2245348	hsa-miR-4470	CLIP-seq
MIRT2245349	hsa-miR-4477a	CLIP-seq
MIRT1057065	hsa-miR-4643	CLIP-seq
MIRT1057066	hsa-miR-4644	CLIP-seq
MIRT2245350	hsa-miR-4677-5p	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT1057074	hsa-miR-4728-3p	CLIP-seq
MIRT1057075	hsa-miR-4732-5p	CLIP-seq
MIRT1057078	hsa-miR-4790-3p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT1057082	hsa-miR-515-5p	CLIP-seq
MIRT2245351	hsa-miR-544	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT1057086	hsa-miR-561	CLIP-seq
MIRT1057088	hsa-miR-582-5p	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT1057040	hsa-miR-1183	CLIP-seq
MIRT2548516	hsa-miR-129-3p	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT2548517	hsa-miR-3140-3p	CLIP-seq
MIRT2548518	hsa-miR-320a	CLIP-seq
MIRT2548519	hsa-miR-320b	CLIP-seq
MIRT2548520	hsa-miR-320c	CLIP-seq
MIRT2548521	hsa-miR-320d	CLIP-seq
MIRT2548522	hsa-miR-330-3p	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057051	hsa-miR-340	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT2548523	hsa-miR-432	CLIP-seq
MIRT2548524	hsa-miR-4426	CLIP-seq
MIRT2548525	hsa-miR-4429	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057062	hsa-miR-4474-5p	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT2548526	hsa-miR-4520a-3p	CLIP-seq
MIRT2548527	hsa-miR-4520b-3p	CLIP-seq
MIRT2548528	hsa-miR-4647	CLIP-seq
MIRT1057067	hsa-miR-4659a-3p	CLIP-seq
MIRT1057068	hsa-miR-4659b-3p	CLIP-seq
MIRT2548529	hsa-miR-4661-5p	CLIP-seq
MIRT2548530	hsa-miR-4662b	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT2548531	hsa-miR-4753-3p	CLIP-seq
MIRT2548532	hsa-miR-4768-5p	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT2548533	hsa-miR-522	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057084	hsa-miR-548p	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT2548534	hsa-miR-889	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT2548535	hsa-miR-938	CLIP-seq
MIRT1057040	hsa-miR-1183	CLIP-seq
MIRT2548516	hsa-miR-129-3p	CLIP-seq
MIRT1057045	hsa-miR-23a	CLIP-seq
MIRT1057046	hsa-miR-23b	CLIP-seq
MIRT1057047	hsa-miR-23c	CLIP-seq
MIRT2548517	hsa-miR-3140-3p	CLIP-seq
MIRT2548518	hsa-miR-320a	CLIP-seq
MIRT2548519	hsa-miR-320b	CLIP-seq
MIRT2548520	hsa-miR-320c	CLIP-seq
MIRT2548521	hsa-miR-320d	CLIP-seq
MIRT2548522	hsa-miR-330-3p	CLIP-seq
MIRT1057050	hsa-miR-338-5p	CLIP-seq
MIRT1057055	hsa-miR-3692	CLIP-seq
MIRT1057056	hsa-miR-369-5p	CLIP-seq
MIRT1057058	hsa-miR-4255	CLIP-seq
MIRT2548523	hsa-miR-432	CLIP-seq
MIRT2548524	hsa-miR-4426	CLIP-seq
MIRT2548525	hsa-miR-4429	CLIP-seq
MIRT1057061	hsa-miR-4452	CLIP-seq
MIRT1057063	hsa-miR-4494	CLIP-seq
MIRT2548526	hsa-miR-4520a-3p	CLIP-seq
MIRT2548527	hsa-miR-4520b-3p	CLIP-seq
MIRT2548528	hsa-miR-4647	CLIP-seq
MIRT1057067	hsa-miR-4659a-3p	CLIP-seq
MIRT1057068	hsa-miR-4659b-3p	CLIP-seq
MIRT2548529	hsa-miR-4661-5p	CLIP-seq
MIRT2548530	hsa-miR-4662b	CLIP-seq
MIRT1057073	hsa-miR-4717-3p	CLIP-seq
MIRT2548531	hsa-miR-4753-3p	CLIP-seq
MIRT2548532	hsa-miR-4768-5p	CLIP-seq
MIRT1057080	hsa-miR-499a-5p	CLIP-seq
MIRT1057081	hsa-miR-513b	CLIP-seq
MIRT2548533	hsa-miR-522	CLIP-seq
MIRT1057083	hsa-miR-548n	CLIP-seq
MIRT1057084	hsa-miR-548p	CLIP-seq
MIRT1057085	hsa-miR-548t	CLIP-seq
MIRT2548534	hsa-miR-889	CLIP-seq
MIRT1057091	hsa-miR-935	CLIP-seq
MIRT2548535	hsa-miR-938	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
FOS	Activation	20188076

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000774	Function	Adenyl-nucleotide exchange factor activity	IBA
GO:0000774	Function	Adenyl-nucleotide exchange factor activity	IDA	24318877
GO:0005515	Function	Protein binding	IPI	17024176, 23349634, 24318877, 25036637
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	12952910
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	9931472
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	21231916
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006986	Process	Response to unfolded protein	IEA
GO:0006986	Process	Response to unfolded protein	TAS	9931472
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0043014	Function	Alpha-tubulin binding	IEA
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	IEA
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	TAS	12952910
GO:0051135	Process	Positive regulation of NK T cell activation	IEA
GO:0051135	Process	Positive regulation of NK T cell activation	TAS	12952910
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071682	Component	Endocytic vesicle lumen	TAS
GO:0140662	Function	ATP-dependent protein folding chaperone	IEA

MIM	HGNC	e!Ensembl
610703	16969	ENSG00000120694

Protein

UniProt ID

Q92598

Protein name

Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1)

Protein function

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins

PDB

6GFA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00012	HSP70	3 → 708	Hsp70 protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. {ECO:0000269|PubMed:10865058, ECO:0000269|PubMed:16232202}.

Sequence

MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHA
NNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAM
LLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALN
YGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKL
VEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGK
MNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGK
DISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVF
SRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKV
KVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGT
QPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEA
NLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQ
DHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELG
QRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVV
RAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPH
QNGECYPNEKNSVNMDLD

Sequence length

858

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum		Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response

HSPH1 (heat shock protein family H (Hsp110) member 1)