CCR9 (C-C motif chemokine receptor 9)

Gene

• Entrez ID: 10803
• Gene name: C-C motif chemokine receptor 9
• Gene symbol: CCR9
• Synonyms (NCBI Gene): CC-CKR-9, CDw199, GPR-9-6, GPR28
• Chromosome: 3
• Chromosome location: 3p21.31
• Summary: The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inf

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018889	hsa-miR-335-5p	Microarray	18185580
MIRT020973	hsa-miR-155-5p	Proteomics	19193853
MIRT021275	hsa-miR-146a-5p	Microarray	18057241
MIRT873296	hsa-miR-1252	CLIP-seq
MIRT873297	hsa-miR-154	CLIP-seq
MIRT873298	hsa-miR-155	CLIP-seq
MIRT873299	hsa-miR-25	CLIP-seq
MIRT873300	hsa-miR-302f	CLIP-seq
MIRT873301	hsa-miR-31	CLIP-seq
MIRT873302	hsa-miR-3128	CLIP-seq
MIRT873303	hsa-miR-32	CLIP-seq
MIRT873304	hsa-miR-362-5p	CLIP-seq
MIRT873305	hsa-miR-363	CLIP-seq
MIRT873306	hsa-miR-367	CLIP-seq
MIRT873307	hsa-miR-3977	CLIP-seq
MIRT873308	hsa-miR-4420	CLIP-seq
MIRT873309	hsa-miR-4428	CLIP-seq
MIRT873310	hsa-miR-4685-5p	CLIP-seq
MIRT873311	hsa-miR-4696	CLIP-seq
MIRT873312	hsa-miR-4773	CLIP-seq
MIRT873313	hsa-miR-500a	CLIP-seq
MIRT873314	hsa-miR-500b	CLIP-seq
MIRT873315	hsa-miR-548aa	CLIP-seq
MIRT873316	hsa-miR-603	CLIP-seq
MIRT873317	hsa-miR-92a	CLIP-seq
MIRT873318	hsa-miR-92b	CLIP-seq
MIRT1959113	hsa-miR-1227	CLIP-seq
MIRT1959114	hsa-miR-421	CLIP-seq
MIRT1959115	hsa-miR-4252	CLIP-seq
MIRT1959116	hsa-miR-4709-5p	CLIP-seq
MIRT2196044	hsa-miR-15a	CLIP-seq
MIRT2196045	hsa-miR-15b	CLIP-seq
MIRT2196046	hsa-miR-16	CLIP-seq
MIRT2196047	hsa-miR-195	CLIP-seq
MIRT2196048	hsa-miR-3137	CLIP-seq
MIRT2196049	hsa-miR-424	CLIP-seq
MIRT2196050	hsa-miR-4524	CLIP-seq
MIRT2196051	hsa-miR-4676-5p	CLIP-seq
MIRT2196052	hsa-miR-497	CLIP-seq
MIRT2196053	hsa-miR-503	CLIP-seq
MIRT2196054	hsa-miR-575	CLIP-seq
MIRT2196055	hsa-miR-646	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002305	Process	CD8-positive, gamma-delta intraepithelial T cell differentiation	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	10229797
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	10229797
GO:0006935	Process	Chemotaxis	TAS	10640743
GO:0006955	Process	Immune response	IBA	21873635
GO:0006968	Process	Cellular defense response	TAS	10544196
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009986	Component	Cell surface	IDA	18308860
GO:0016032	Process	Viral process	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IBA	21873635
GO:0019957	Function	C-C chemokine binding	IBA	21873635
GO:0060326	Process	Cell chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA

Other IDs

• MIM: 604738
• HGNC: 1610
• e!Ensembl: ENSG00000173585

Protein

• UniProt ID: P51686
• Protein name: C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (G-protein coupled receptor 28) (GPR-9-6) (CD antigen CDw199)
• Protein function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. ; (Microbial infection) Alternative coreceptor with CD4
• PDB: 5LWE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	65 → 317	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the thymus and low in lymph nodes and spleen. {ECO:0000269|PubMed:10229797, ECO:0000269|PubMed:10640743}.
• Sequence:

  MTPTDFTSPIPNMADDYGSESTSSMEDYVNFNFTDFYCEKNNVRQFASHFLPPLYWLVFI
  VGALGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLVTLPFWAIAAADQWKFQTFMCK
  VVNSMYKMNFYSCVLLIMCISVDRYIAIAQAMRAHTWREKRLLYSKMVCFTIWVLAAALC
  IPEILYSQIKEESGIAICTMVYPSDESTKLKSAVLTLKVILGFFLPFVVMACCYTIIIHT
  LIQAKKSSKHKALKVTITVLTVFVLSQFPYNCILLVQTIDAYAMFISNCAVSTNIDICFQ
  VTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFTRREGSLKLSSMLL
  ETTSGALSL

• Sequence length: 369

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Intestinal immune network for IgA production

Reactome:

Chemokine receptors bind chemokines
G alpha (i) signalling events