CYSLTR1 (cysteinyl leukotriene receptor 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10800
Gene name Gene Name - the full gene name approved by the HGNC.
Cysteinyl leukotriene receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CYSLTR1
Synonyms (NCBI Gene) Gene synonyms aliases
CYSLT1, CYSLT1R, CYSLTR, HMTMF81
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system.
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT017591 hsa-miR-335-5p Microarray 18185580
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
STAT6 Unknown 16210619
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(22)
GO ID Ontology Definition Evidence Reference
GO:0001631 Function Cysteinyl leukotriene receptor activity IBA
GO:0002437 Process Inflammatory response to antigenic stimulus IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004966 Function Galanin receptor activity IBA
GO:0004974 Function Leukotriene receptor activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
300201 17451 ENSG00000173198
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9Y271
Protein name Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81)
Protein function Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus laye
PDB 6RZ4 , 6RZ5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 40 → 295 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon a
Sequence
Sequence length 337
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Calcium signaling pathway
Neuroactive ligand-receptor interaction 		  Leukotriene receptors
G alpha (q) signalling events
LTC4-CYSLTR mediated IL4 production
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Coronary artery disease Coronary artery disease N/A N/A GWAS
Show/Hide Text Mining Associations (36)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Disease Associate 20003473
Asthma Associate 11509632, 17153879, 18829683, 20003473, 21799837, 23524649, 23977066, 28623130
Asthma Stimulate 24641287
Atherosclerosis Associate 24253666
Carcinogenesis Associate 28600709
Cardiovascular Diseases Associate 24253666
Colorectal Neoplasms Associate 21203429, 22194989, 23829413, 36834820
COVID 19 Associate 37686182, 38171849
Drug Hypersensitivity Associate 11509632, 23977066, 24350867
Drug Hypersensitivity Inhibit 20159258