MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10797 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MTHFD2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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NMDMC |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2p13.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for ma |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | P13995 | |||||||||||||||
| Protein name | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] | |||||||||||||||
| Protein function | Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | |||||||||||||||
| PDB | 5TC4 , 6JIB , 6JID , 6KG2 , 6S4A , 6S4E , 6S4F , 7EHJ , 7EHM , 7EHN , 7EHV , 9IS9 , 9ISC , 9IT3 , 9IT6 , 9ITA | |||||||||||||||
| Family and domains |
Pfam
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| Sequence | ||||||||||||||||
| Sequence length | 350 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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