Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10797
Gene name Gene Name - the full gene name approved by the HGNC.
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MTHFD2
Synonyms (NCBI Gene) Gene synonyms aliases
NMDMC
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for ma
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001354 hsa-miR-1-3p pSILAC 18668040
MIRT021039 hsa-miR-155-5p Proteomics 18668040
MIRT001354 hsa-miR-1-3p Proteomics;Other 18668040
MIRT031940 hsa-miR-16-5p Proteomics 18668040
MIRT047797 hsa-miR-30d-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 8218174
GO:0000287 Function Magnesium ion binding IMP 16100107
GO:0004477 Function Methenyltetrahydrofolate cyclohydrolase activity IBA 21873635
GO:0004477 Function Methenyltetrahydrofolate cyclohydrolase activity ISS 8218174
GO:0004487 Function Methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604887 7434 ENSG00000065911
Protein
UniProt ID P13995
Protein name Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]
Protein function Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
PDB 5TC4 , 6JIB , 6JID , 6KG2 , 6S4A , 6S4E , 6S4F , 7EHJ , 7EHM , 7EHN , 7EHV , 9IS9 , 9ISC , 9IT3 , 9IT6 , 9ITA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00763 THF_DHG_CYH 39 155 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Domain
PF02882 THF_DHG_CYH_C 158 332 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Domain
Sequence
Sequence length 350
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  One carbon pool by folate
Metabolic pathways
Biosynthesis of cofactors
  Metabolism of folate and pterines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Hodgkin lymphoma Adult Hodgkin Lymphoma 24688052 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Adenine Nucleotide Translocator Deficiency Inhibit 30532069
Adenocarcinoma of Lung Stimulate 36138435
Breast Neoplasms Associate 22761433, 24870594, 27315223, 35349697, 38310106
Breast Neoplasms Stimulate 23295955, 24451681
Calcinosis Cutis Associate 23295955
Carcinogenesis Associate 30532069
Carcinoma Hepatocellular Associate 30482855
Carcinoma Hepatocellular Stimulate 38287824
Carcinoma Non Small Cell Lung Associate 33015789, 36827714
Carcinoma Non Small Cell Lung Stimulate 36051358